He played for the Bishop's College School and then Université de SherbrookeVert-et-Or In 2005, he caught 30 passes for 984 yards and four touchdowns. He was also a member of the Junior Canadian Team and was one of the fastest players in the AAA Collegial Ligue. In 2006, he was the fourth-leading wide receiver with 19 receptions for 464 yards. He tied the record for most touchdown receptions (3) in a game against Acadia University. Giguère was named offensive player of the week in the QUFL, the Quebec University Football League. That year, Giguère was named to the QUFL all-star team. He was also runner-up for the Université de Sherbrooke rookie of the year award in 2005–2006. In 2007, Samuel Giguère caught 45 passes for 871 yards and seven touchdowns and was a first-team all-conference selection and a first-team All Canadian. He finished the year ranked second in yards and third in yards per game (108.9) and had all career KOR totals as a Senior
After spending the entire 2008 season on the practice squad, Giguère was re-signed to a future contract on January 5, 2009. He was once again waived during final cuts on September 5, only to be re-signed to the practice squad two days later.[3] Giguère was promoted to the Colts' active roster on December 30, 2009, after the team waived quarterbackDrew Willy.
He spent the 2010 off-season with the Colts and was waived on September 4, 2010, as part of the team's final cuts.[4]
New York Giants
Giguère was signed to the New York Giants' practice squad on October 19. After he injured his groin in training camp in 2011 and was waived/injured, he was released with an injury settlement on August 23, 2011.[5]
Hamilton Tiger-Cats
One day before the 2012 CFL Draft, Giguère signed with the Hamilton Tiger-Cats of the Canadian Football League. The Tiger-Cats had selected Giguère with the eighth overall pick in the 2008 CFL Draft.[6] In his first season in the CFL, Giguère totalled 549 yards and one touchdown. Giguère's involvement remained about the same over the next two seasons, catching 34 passes for 474 in 2013 and 41 for 520 in 2014.
Montreal Alouettes
Upon entering free agency, Giguère signed with the Montreal Alouettes on February 12, 2015.[7] In three seasons in Montreal, Giguère played in 47 games catching 86 passes for 915 yards with ten touchdowns. On January 19, 2018, Giguère was released.[8]
Edmonton Eskimos
On June 26, 2018, early in the 2018 season, Giguère signed with the Edmonton Eskimos.[9] Giguère was released on August 14, 2018, but was re-signed on August 20, 2018.