Saint-Esprit was founded in the 18th century. The economy of the village used to based on sugar plantations.[4] The original name of the village was Bourg des Coulisses, due to the sugar cane which was transported by streams from the hill down to the mill in the valley.[5] In 1833, Saint-Esprit was established as a commune.[5]
The Saint-Esprit Church was constructed in 1758 by the Capuchins.[5] The church was relocated, and its former location is currently in use by the hospital. One of the bells of the church is named Sebastopol, and was taken during the Crimean War.[6]
The village is located in a forested zone along the Cacaos and the Coulisses River.[7]