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SPOCK1
Identifiers
Aliases	SPOCK1, SPOCK, TESTICAN, TIC1, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
External IDs	OMIM: 602264; MGI: 105371; HomoloGene: 80193; GeneCards: SPOCK1; OMA:SPOCK1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	137,598,379 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	58,056,146 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; lateral nuclear group of thalamus; ; decidua; ; postcentral gyrus; ; Brodmann area 46; ; orbitofrontal cortex; ; cerebellar cortex; ; cerebellar hemisphere; ; superior frontal gyrus; ; right hemisphere of cerebellum;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; superior frontal gyrus; ; primary visual cortex; ; olfactory system; ; olfactory epithelium; ; cerebellar cortex; ; Gray matter of spinal cord; ; anterior horn of spinal cord; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; cysteine-type endopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity; collagen binding; extracellular matrix binding;
Cellular component	cytoplasm; postsynaptic density; neuromuscular junction; node of Ranvier; extracellular region; sarcoplasm; extracellular space;
Biological process	negative regulation of cell-substrate adhesion; neurogenesis; negative regulation of neuron projection development; neuron migration; nervous system development; cell adhesion; regulation of cell growth; central nervous system neuron differentiation; signal transduction; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	6695
	20745
	ENSG00000152377
	ENSMUSG00000056222
	Q08629
	Q62288
	NM_004598
	NM_001166463; NM_001166464; NM_001166465; NM_001166466; NM_009262
	NP_004589
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Testican-1 is a protein that in humans is encoded by the SPOCK1 gene.^[5]^[6]

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152377 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056222 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Charbonnier F, Perin JP, Mattei MG, Camuzat A, Bonnet F, Gressin L, Alliel PM (Jun 1998). "Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31". Genomics. 48 (3): 377–80. doi:10.1006/geno.1997.5199. PMID 9545645.
^ ^a ^b "Entrez Gene: SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1".

Périn JP, Alliel PM, Jollès P, Bonnet F (1994). "Proteoglycans in male reproductive tract". Exs. 70: 191–7. doi:10.1007/978-3-0348-7545-5_11 (inactive 1 November 2024). ISBN 978-3-0348-7547-9. PMID 7507743.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
Charbonnier F, Périn JP, Roussel G, et al. (1997). "[Cloning of testican/SPOCK in man and mouse. Neuromuscular expression perspectives in pathology]". C. R. Séances Soc. Biol. Fil. 191 (1): 127–33. PMID 9181134.
Alliel PM, Perin JP, Jollès P, Bonnet FJ (1993). "Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour". Eur. J. Biochem. 214 (1): 347–50. doi:10.1111/j.1432-1033.1993.tb17930.x. PMID 8389704.
Bonnet F, Périn JP, Charbonnier F, et al. (1996). "Structure and cellular distribution of mouse brain testican. Association with the postsynaptic area of hippocampus pyramidal cells". J. Biol. Chem. 271 (8): 4373–80. doi:10.1074/jbc.271.8.4373. PMID 8626787.
Marr HS, Basalamah MA, Edgell CJ (1998). "Endothelial cell expression of testican mRNA". Endothelium. 5 (3): 209–19. doi:10.3109/10623329709053399. PMID 9272383.
Kohfeldt E, Maurer P, Vannahme C, Timpl R (1997). "Properties of the extracellular calcium binding module of the proteoglycan testican". FEBS Lett. 414 (3): 557–61. Bibcode:1997FEBSL.414..557K. doi:10.1016/S0014-5793(97)01070-3. PMID 9323035. S2CID 25552375.
Marr HS, Basalamah MA, Bouldin TW, et al. (2001). "Distribution of testican expression in human brain". Cell Tissue Res. 302 (2): 139–44. doi:10.1007/s004410000277. PMID 11131125. S2CID 9937680.
BaSalamah MA, Marr HS, Duncan AW, Edgell CJ (2001). "Testican in human blood". Biochem. Biophys. Res. Commun. 283 (5): 1083–90. doi:10.1006/bbrc.2001.4900. PMID 11355883.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakada M, Miyamori H, Yamashita J, Sato H (2003). "Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins". Cancer Res. 63 (12): 3364–9. PMID 12810672.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. Bibcode:2004Natur.431..268S. doi:10.1038/nature02919. PMID 15372022.
Prenzel KL, Warnecke-Eberz U, Xi H, et al. (2006). "Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater". Oncol. Rep. 15 (5): 1397–401. doi:10.3892/or.15.5.1397. PMID 16596217.