SFRS9

SRSF9

Identifiers

SRSF9, SFRS9, SRp30c, serine/arginine-rich splicing factor 9, serine and arginine rich splicing factor 9

External IDs

OMIM: 601943; MGI: 104896; HomoloGene: 20819; GeneCards: SRSF9; OMA:SRSF9 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q24.31	Start	120,461,672 bp^[1]
Band	12q24.31	End	120,469,748 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 F	Start	115,465,236 bp^[2]
Band	5\|5 F	End	115,471,139 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

body of pancreas

monocyte

ventricular zone

buccal mucosa cell

right testis

ganglionic eminence

beta cell

palpebral conjunctiva

mucosa of pharynx

right adrenal cortex

Top expressed in

renal corpuscle

Gonadal ridge

epiblast

endocardial cushion

somite

molar

medullary collecting duct

hand

primitive streak

ureter

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding nucleic acid binding RNA binding protein domain specific binding
Cellular component	nucleolus nucleus nucleoplasm nuclear speck
Biological process	mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing negative regulation of mRNA splicing, via spliceosome mRNA splice site selection mRNA export from nucleus mRNA 3'-end processing response to alkaloid RNA export from nucleus RNA splicing response to toxic substance regulation of alternative mRNA splicing, via spliceosome mRNA cis splicing, via spliceosome
Sources:Amigo / QuickGO

Species

Human

Mouse


8683


108014


ENSG00000111786


ENSMUSG00000029538


Q13242


Q9D0B0

RefSeq (mRNA)


NM_003769


NM_025573

RefSeq (protein)


NP_003760


NP_079849

Location (UCSC)

Chr 12: 120.46 – 120.47 Mb

Chr 5: 115.47 – 115.47 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.^[5]

Interactions

SFRS9 has been shown to interact with Y box binding protein 1^[6] and NOL3.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111786 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029538 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SFRS9 splicing factor, arginine/serine-rich 9".
^ Raffetseder, Ute; Frye Björn; Rauen Thomas; Jürchott Karsten; Royer Hans-Dieter; Jansen Petra Lynen; Mertens Peter R (May 2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi:10.1074/jbc.M212518200. ISSN 0021-9258. PMID 12604611.
^ Stoss, O; Schwaiger F W; Cooper T A; Stamm S (Apr 1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi:10.1074/jbc.274.16.10951. ISSN 0021-9258. PMID 10196175.

Further reading

Screaton GR, Cáceres JF, Mayeda A, et al. (1995). "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors". EMBO J. 14 (17): 4336–49. doi:10.1002/j.1460-2075.1995.tb00108.x. PMC 394518. PMID 7556075.
Nayler O, Strätling W, Bourquin JP, et al. (1998). "SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements". Nucleic Acids Res. 26 (15): 3542–9. doi:10.1093/nar/26.15.3542. PMC 147731. PMID 9671816.
Yuan Y; Li DM; Sun H (1998). "PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes". J. Biol. Chem. 273 (32): 20347–53. doi:10.1074/jbc.273.32.20347. PMID 9685386.
Petersen-Mahrt SK, Estmer C, Ohrmalm C, et al. (1999). "The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation". EMBO J. 18 (4): 1014–24. doi:10.1093/emboj/18.4.1014. PMC 1171193. PMID 10022843.
Stoss O; Schwaiger FW; Cooper TA; Stamm S (1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi:10.1074/jbc.274.16.10951. PMID 10196175.
Elliott DJ, Bourgeois CF, Klink A, et al. (2000). "A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5717–22. Bibcode:2000PNAS...97.5717E. doi:10.1073/pnas.97.11.5717. PMC 18499. PMID 10823932.
Stoss O, Olbrich M, Hartmann AM, et al. (2001). "The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites". J. Biol. Chem. 276 (12): 8665–73. doi:10.1074/jbc.M006851200. PMID 11118435.
Denegri M, Chiodi I, Corioni M, et al. (2002). "Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors". Mol. Biol. Cell. 12 (11): 3502–14. doi:10.1091/mbc.12.11.3502. PMC 60271. PMID 11694584.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Young PJ, DiDonato CJ, Hu D, et al. (2002). "SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1". Hum. Mol. Genet. 11 (5): 577–87. doi:10.1093/hmg/11.5.577. PMID 11875052.
Simard MJ; Chabot B (2002). "SRp30c is a repressor of 3' splice site utilization". Mol. Cell. Biol. 22 (12): 4001–10. doi:10.1128/MCB.22.12.4001-4010.2002. PMC 133842. PMID 12024014.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Raffetseder U, Frye B, Rauen T, et al. (2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi:10.1074/jbc.M212518200. PMID 12604611.
Xu Q; Leung DY; Kisich KO (2003). "Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils". J. Biol. Chem. 278 (29): 27112–8. doi:10.1074/jbc.M300824200. PMID 12738786.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Kondo S, Yamamoto N, Murakami T, et al. (2004). "Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA". Genes Cells. 9 (2): 121–30. doi:10.1111/j.1356-9597.2004.00709.x. PMID 15009090. S2CID 22248867.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wang Y, Wang J, Gao L, et al. (2005). "Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1". J. Biol. Chem. 280 (14): 14230–9. doi:10.1074/jbc.M413846200. PMID 15695522.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. Bibcode:2006Natur.440..346S. doi:10.1038/nature04569. PMID 16541075.

v t e PDB gallery
1wg4: Solution structure of RRM domain in protein BAB31986

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

Read other articles:

Katamari Damacy

Katamari_Damacy

Katamari Damacy Gambar sampul Amerika UtaraPublikasiGenreTeka-teki, aksiKarakteristik teknisPlatformPlayStation 2 Modepermainan video multipemain dan Permainan video pemain tunggal FormatDVD Metode inputgamepad Format kode Daftar 30 Informasi pengembangPembuatKeita Takahashi (en) PengembangNamcoPenyuntingBandai Namco Entertainment PengarahKeita TakahashiProdusenHideki TomidaMitsumasa FujitaDesainerMasatoshi OgitaKomponisYuu MiyakeAsuka SakaiAkitaka TohyamaHideki TobetaYoshihito YanoYuri Misum...

توماش هوبتشمان

توماش هوبتشمان معلومات شخصية الميلاد 4 سبتمبر 1981 (العمر 42 سنة)براغ الطول 1.80 م (5 قدم 11 بوصة) مركز اللعب قلب الدفاع الجنسية جمهورية التشيك معلومات النادي النادي الحالي يابلونتس الرقم 3 مسيرة الشباب سنوات فريق 1986–1998 سبارتا براغ المسيرة الاحترافية1 سنوات فريق م. (...

Charte européenne des langues régionales ou minoritaires

Charte_européenne_des_langues_régionales_ou_minoritaires

Charte européenne des langues régionales ou minoritaires Données clés Les membres de la Charte. Pays ayant ratifié la Charte. Pays ayant signé mais pas ratifié la Charte. Pays membres du Conseil de l'Europe n'ayant pas signé la Charte. Pays non membres du Conseil de l'Europe. Présentation Référence ETS 148 Organisation internationale Conseil de l'Europe Langue(s) officielle(s) Certifiées conformes : anglais et français ; Nombreuses traductions officielles (liste) Type ...

دوري هونغ كونغ لكرة القدم 1964–65

دوري_هونغ_كونغ_لكرة_القدم_1964–65

هذه المقالة تحتاج للمزيد من الوصلات للمقالات الأخرى للمساعدة في ترابط مقالات الموسوعة. فضلًا ساعد في تحسين هذه المقالة بإضافة وصلات إلى المقالات المتعلقة بها الموجودة في النص الحالي. (أبريل 2020) يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة ...

Jean de Labadie

Jean_de_Labadie

French Pietist Jean de LabadieBornJean de Labadie(1610-02-13)13 February 1610Died13 February 1674(1674-02-13) (aged 64) Jean de Labadie (13 February 1610 – 13 February 1674) was a 17th-century French Pietist. Originally a Jesuit priest, he became a member of the Reformed Church in 1650, before founding the community which became known as the Labadists in 1669. At its height the movement numbered around 600 with thousands of adherents further afield. It attracted some notable female con...

Traité de Campo-Formio

Traité_de_Campo-Formio

Pour les articles homonymes, voir Campo-Formio (homonymie). Traité de Campo-Formio Dernière page du traité avec les cachets et les paraphes des signataires, conservée aux Archives nationales françaises.Traité de paix définitif conclu entre la République française et l’empereur des Romains, roi de Hongrie et de Bohême. Type de traité Traité de paix Langue Français Données clés Ébauche 17 octobre 1797(26 vendémiaire an VI)(Villa Manin, (Passariano, Codroipo)) Signé 18 octob...

Jacopo II Appiano

Jacopo_II_Appiano

Jacopo IIJacopo Appiano (primo a destra) ritratto da Bicci di Lorenzo, Santa Maria Nuova, Firenze[1]Signore di PiombinoStemma In carica1404 -1441 PredecessoreGherardo SuccessorePaola Colonna NascitaPiombino, aprile 1399 MortePiombino, 27 dicembre 1441 SepolturaDuomo di Piombino DinastiaAppiano PadreGherardo Appiano MadrePaola Colonna ConsorteDonella Fieschi ReligioneCattolicesimo Jacopo II Appiano (Piombino, aprile 1399 – Piombino, 27 dicembre 1441) fu il secondo signore di Pi...

Stasiun Ōdate

Stasiun Ōdate大館駅Stasiun Ōdate pada Nov. 2023Lokasi1-3-1 Onari-chō, Ōdate-shi, Akita-ken 017-0044JepangKoordinat40°17′16.8″N 140°33′23.4″E / 40.288000°N 140.556500°E / 40.288000; 140.556500Koordinat: 40°17′16.8″N 140°33′23.4″E / 40.288000°N 140.556500°E / 40.288000; 140.556500Operator JR East JR Freight Jalur ■ Jalur Utama Ōu ■ Jalur Hanawa Letak402.9 kilometer dari FukushimaJumlah peron1 peron samping + 1 p...

Sorrow (emotion)

Sorrow_(emotion)

Emotion of prolonged, resigned sadness Sorrow, drawing by Vincent van Gogh, 1882 Part of a series onEmotions Affect Classification In animals Emotional intelligence Mood Regulation Interpersonal Dysregulation Valence Emotions Acceptance Admiration Affection Amusement Anger Angst Anguish Annoyance Anticipation Anxiety Apathy Arousal Awe Belongingness Boredom Confidence Confusion Contempt Contentment Courage Curiosity Depression Desire Determination Disappointment Disgust Distrust Doubt Ecstasy...

Taeniasis

Artikel ini memberikan informasi dasar tentang topik kesehatan. Informasi dalam artikel ini hanya boleh digunakan untuk penjelasan ilmiah; bukan untuk diagnosis diri dan tidak dapat menggantikan diagnosis medis. Wikipedia tidak memberikan konsultasi medis. Jika Anda perlu bantuan atau hendak berobat, berkonsultasilah dengan tenaga kesehatan profesional. TaeniasisTemuan proglotid (segmen tubuh) Taenia dalam tinja merupakan tanda taeniasisInformasi umumSpesialisasiPenyakit menular TipeInfe...

Degeneriaceae

Degeneriaceae Klasifikasi ilmiah Kerajaan: Plantae (tanpa takson): Tracheophyta (tanpa takson): Angiospermae (tanpa takson): Magnoliids Ordo: Magnoliales Famili: DegeneriaceaeI.W.Bailey & A.C.Sm.[1] Genus: DegeneriaI.W.Bailey & A.C.Sm. Spesies Degeneria roseiflora Degeneria vitiensis Degeneriaceae adalah famili tumbuhan berbunga endemik Fiji. Famili ini hanya memiliki satu genus tumbuhan saja yakni Degeneria. Sistem klasifikasi APG IV tahun 2016 mengakui keluarga ini, dan mem...

Prosper Levot

French naval historian You can help expand this article with text translated from the corresponding article in French. (January 2011) Click [show] for important translation instructions. View a machine-translated version of the French article. Machine translation, like DeepL or Google Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text ...

Title 14 of the United States Code

Title_14_of_the_United_States_Code

U.S. federal statutes on the Coast Guard This article is part of a series on theUnited States Code United States Code Title 1 - General Provisions Title 2 - The Congress Title 3 - The President Title 4 - Flag and Seal, Seat of Government, and the States Title 5 - Government Organization and Employees Title 6 - Domestic Security Title 7 - Agriculture Title 8 - Aliens and Nationality Title 9 - Arbitration Title 10 - Armed Forces Title 11 - Bankruptcy Title 12 - Banks and Banking Title 13 - Cens...

Xfce

Desktop environment XFCEXFCE 4.14 with customized panel and Whisker Menu on Debian 11Original author(s)Olivier FourdanDeveloper(s)Free software community[1]Initial release1997; 27 years ago (1997)Stable release4.18[2] / 15 December 2022 Repositorygitlab.xfce.org/xfceWritten inC (GTK)MiddlewareX Window System, XorgEngineGTKOperating systemLinux, FreeBSD, NetBSD, OpenBSD and GNU/Hurd.PlatformUnix-likeAvailable inat least 31 different languagesTypeDesktop ...

Пугачёва, Алла Борисовна

Пугачёва,_Алла_Борисовна

Запрос «Пугачёва» перенаправляется сюда; см. также другие значения. Алла Пугачёва На фестивале «Славянский базар в Витебске», 2016 год Основная информация Полное имя Алла Борисовна Пугачёва Дата рождения 15 апреля 1949(1949-04-15) (75 лет) Место рождения Москва, СССР[1]...

Danielle Moonstar

Danielle_Moonstar

Fictional superhero Psyche (comics) redirects here. For the League of Champions character, see Psyche (Heroic Publishing). Comics character Danielle MoonstarDani Moonstar on the variant cover for The Fearless Defenders #4.Publication informationPublisherMarvel ComicsFirst appearanceThe New Mutants(September 1982)Created byChris ClaremontBob McLeodIn-story informationFull nameDanielle Dani MoonstarSpeciesHuman mutantTeam affiliationsHellionsThe InitiativeMutant Liberation FrontNew MutantsS.H.I...

Gold Key Comics

Gold_Key_Comics

American comic book publisher Gold Key ComicsFounded1962Defunct1984Country of originUnited StatesPublication typesComic booksOwner(s)Western Publishing (defunct) Gold Key Comics was an imprint of American company Western Publishing, created for comic books distributed to newsstands. Also known as Whitman Comics, Gold Key operated from 1962 to 1984. History Gold Key Comics was created in 1962, when its parent, Western Publishing Company, switched to in-house publishing rather than packaging co...

Roman Shvartsman

Roman_Shvartsman

Ukrainian Jewish concentration camp survivor (born 1936) Roman ShvartsmanShvartsman in his officeBornShvartsman Ruvin Mordkovich[citation needed] (1936-11-07) November 7, 1936 (age 87)Bershad, Ukrainian SSRAlma materOdesa National Maritime UniversityOccupationsPublic figureChairman of Odesa regional Association of Jews – former prisoners of ghetto and nazi concentration campsAwards Roman Markovich Shvartsman (born November 7, 1936) is chairman of the Odesa regional Associa...

Template talk:Lao cuisine

Template_talk:Lao_cuisine

Food and drink Template‑class Food portalThis template is within the scope of WikiProject Food and drink, a collaborative effort to improve the coverage of food and drink related articles on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Food and drinkWikipedia:WikiProject Food and drinkTemplate:WikiProject Food and drinkFood and drink articlesTemplateThis template does not require a rating on Wikipe...

星洲网

星洲网网站类型新闻网站语言简体中文總部马来西亚雪兰莪州八打灵再也Semangat路19号（星洲日报总部）持有者世华多媒体有限公司編輯卜亚烈网址www.sinchew.com.my商业性质是注册选择性（个人新闻空间）推出时间2000年4月21日，24年前（2000-04-21）內容許可保有版权星洲网，是一家马来西亚线上免费综合新闻网站，也是马来西亚销售量最高的中文报《星洲日报》...