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SF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K1G, 1O0P, 1OPI, 2M09, 4FXW, 4FXX
Identifiers
Aliases	SF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162, splicing factor 1
External IDs	OMIM: 601516; MGI: 1095403; HomoloGene: 138518; GeneCards: SF1; OMA:SF1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,778,786 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; left ovary; ; tibial nerve; ; gastric mucosa; ; right ovary; ; right lobe of thyroid gland; ; left uterine tube; ; canal of the cervix; ; right hemisphere of cerebellum; ; left lobe of thyroid gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity; zinc ion binding; metal ion binding; protein binding; nucleic acid binding; identical protein binding; pre-mRNA branch point binding; RNA binding;
Cellular component	ribosome; spliceosomal complex; nucleus; nucleoplasm; nuclear body;
Biological process	negative regulation of smooth muscle cell proliferation; regulation of transcription, DNA-templated; Leydig cell differentiation; mRNA processing; regulation of steroid biosynthetic process; male sex determination; transcription, DNA-templated; spliceosomal complex assembly; mRNA 3'-splice site recognition; RNA splicing; negative regulation of nucleic acid-templated transcription; mRNA splicing, via spliceosome; nuclear body organization;
	Sources:Amigo / QuickGO
Orthologs
	7536
	22668
	ENSG00000168066
	ENSMUSG00000024949
	Q15637
	Q64213
NM_001178030; NM_001178031; NM_004630; NM_201995; NM_201997;
	NM_201998; NM_001346363; NM_001346364; NM_001346409; NM_001346410; NM_001378956; NM_001378957
	NM_001110791; NM_011750
NP_001171501; NP_001171502; NP_001333292; NP_001333293; NP_001333338;
	NP_001333339; NP_004621; NP_973724; NP_973726; NP_973727; NP_001365885; NP_001365886
NP_001104261; NP_035880; NP_001347322; NP_001390363; NP_001390364;
	NP_001390365; NP_001390368; NP_001390369; NP_001390370; NP_001390371; NP_001390372; NP_001390373; NP_001390374; NP_001390375; NP_001390376; NP_001390377; NP_001390378
	Wikidata
View/Edit Human	View/Edit Mouse

Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.^[4]^[5]^[6]

Splicing factor SF1 is involved in the ATP-dependent formation of the spliceosome complex.^[7] SF1 gene is necessary to make the bipotential gonad; but while SF1 levels decline in the genital ridge of XX mouse embryos, the SF1 gene stays on the developing testes. SF 1 (transcription factor) appears to be active in masculining both the Leydig cells and Sertoli cells. In Sertoli cells with the SOX9 protein it elevates the level of AMH transcription. In Leydig cells it activates the gene encoding the enzyme that make testosterone hormone.

Interactions

SF1 (gene) has been shown to interact with Ewing sarcoma breakpoint region 1,^[8] U2AF2,^[9]^[10]^[11] Testis determining factor,^[12] and transcription elongation regulator 1.^[13]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168066 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Toda T, Iida A, Miwa T, Nakamura Y, Imai T (Jul 1994). "Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1)". Hum Mol Genet. 3 (3): 465–70. doi:10.1093/hmg/3.3.465. PMID 7912130.
^ Kramer A, Quentin M, Mulhauser F (Jun 1998). "Diverse modes of alternative splicing of human splicing factor SF-1 deduced from the exon-intron structure of the gene". Gene. 211 (1): 29–37. doi:10.1016/S0378-1119(98)00058-4. PMID 9573336.
^ "Entrez Gene: SF1 splicing factor 1".
^ Rino J, Desterro JM, Pacheco TR, Gadella TW, Carmo-Fonseca M (May 2008). "Splicing factors SF1 and U2AF associate in extraspliceosomal complexes". Mol. Cell. Biol. 28 (9): 3045–57. doi:10.1128/MCB.02015-07. PMC 2293075. PMID 18285458.
^ Zhang D, Paley AJ, Childs G (July 1998). "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription". J. Biol. Chem. 273 (29): 18086–91. doi:10.1074/jbc.273.29.18086. PMID 9660765.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Berglund JA, Abovich N, Rosbash M (March 1998). "A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition". Genes Dev. 12 (6): 858–67. doi:10.1101/gad.12.6.858. PMC 316625. PMID 9512519.
^ Abovich N, Rosbash M (May 1997). "Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals". Cell. 89 (3): 403–12. doi:10.1016/S0092-8674(00)80221-4. PMID 9150140. S2CID 18466775.
^ Kashimada K, Koopman P (December 2010). "Sry: the master switch in mammalian sex determination". Development. 137 (23): 3921–30. doi:10.1242/dev.048983. PMID 21062860.
^ Goldstrohm AC, Albrecht TR, Suñé C, Bedford MT, Garcia-Blanco MA (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. PMC 99933. PMID 11604498.