Russell bodies

Mott cells with Russell bodies (red arrows), compared to an almost normal plasma cell (white arrow; it has a prominent nucleolus).
Plasmacytoma with abundant Russell bodies. H&E stain.
Dutcher and Russell bodies. H&E stain.

Russell bodies are inclusion bodies usually found in atypical plasma cells that become known as Mott cells.[1] Russell bodies are eosinophilic, homogeneous immunoglobulin (Ig)-containing inclusions usually found in cells undergoing excessive synthesis of Ig; the Russell body is characteristic of the distended endoplasmic reticulum. Russell bodies are large and globular of varying size, and become packed into the cell's cytoplasm pushing the nucleus to the edge of the cell, and are found in the peripheral areas of tumors. Russell bodies are thought to have originated as abnormal proteins that have not been secreted. The excess immunoglobulin builds up and forms intracytoplasmic globules, which is thought to be a result of insufficient protein transport within the cell. This causes the proteins to neither be degraded or secreted and stay stored in dilated cisternae.[2] In 1949, Pearse discovered that Russell bodies also contain mucoproteins that are secreted by plasma cells. Russell bodies are not tissue specific; during research they were induced in rat glioma cells.[3] Russell bodies were found to have positive reactions to PAS stain, CD 38 and CD 138 stains. Plasma cells that contain Russell bodies and are stained with H&E stain are found to be autofluorescent, while those without Russell bodies are not.[citation needed] Russell bodies tend to be found in places with chronic inflammation.[citation needed]

This is one cell variation found in multiple myeloma.[4]

Similar inclusion bodies that tend to overlie the nucleus or invaginate into it are known as Dutcher bodies.[5]

They are named for William Russell (1852–1940), a Scottish physician.[6][7]

References

  1. ^ Fellows, IW; Leach, IH; Smith, PG; Toghill, PJ; Doran, J (June 1990). "Carcinoid tumour of the common bile duct--a novel complication of von Hippel-Lindau syndrome". Gut. 31 (6): 728–9. doi:10.1136/gut.31.6.728. PMC 1378509. PMID 2379881.
  2. ^ Rubio, C.A. (2005). "Mott Cell (Russell Bodies) Barrett's Oesophagitis" (PDF). In Vivo. 19 (6): 1097–1100. PMID 16277029.
  3. ^ Valetti, C., Grossi, C.E., Milstein, C., Sitia, R. (November 15, 1991). "Russell Bodies: A General Response of Secretory Cells to Synthesis of a Mutant Immunoglobulin Which Can Neither Exit from, Nor Be Degraded in, the Endoplasmic Reticulum". The Journal of Cell Biology. 115 (4): 983–994. doi:10.1083/jcb.115.4.983. PMC 2289943. PMID 1955467.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Martín-Noya A, Ríos-Herranz E, Rafel-Ribas E (February 1999). "Multiple myeloma with numerous intranuclear Russell bodies". Haematologica. 84 (2): 179–80. PMID 10091418.
  5. ^ "Dutcher Body in Recurrent Lymphoplasmacytic Lymphoma". imagebank.hematology.org. Retrieved 8 May 2021.
  6. ^ synd/1962 at Who Named It?
  7. ^ Russell, W. (1890). "An Address on a Characteristic Organism of Cancer". BMJ. 2 (1563): 1356–1360. doi:10.1136/bmj.2.1563.1356. PMC 2208600. PMID 20753194.


Stub icon

This article related to pathology is a stub. You can help Wikipedia by expanding it.

Read other articles:

Jung Dong-hwan

Dalam nama Korean ini, nama keluarganya adalah Jung. Jung Dong-hwanLahir5 Agustus 1949 (umur 74)Gimje, Provinsi Jeolla Utara, Korea SelatanPekerjaanAktorTahun aktif1969-sekarangSuami/istriJung Yoon-sunAnak1 putra, 2 putri[1]Nama KoreaHangul정동환 Alih AksaraJeong Dong-hwanMcCune–ReischauerChŏng Tong-hwan Jung Dong-hwan (lahir 5 Agustus 1949) adalah aktor Korea Selatan. Filmografi Film Tahun Judul Peran 1982 Late Autumn[2] Min-gi 1986 Getting on the Elevator Tae...

 

 

Marriage is A Crazy Thing

Marriage is a Crazy ThingPoster teatrikalSutradaraYoo HaDitulis olehYoo HaPemeranEom Jeong-hwaGam Wu-seongPenyuntingPark Gok-jiTanggal rilis 26 April 2002 (2002-04-26) Durasi103 menitNegaraKorea SelatanBahasaBahasa Korea Marriage is a Crazy Thing adalah film Korea Selatan kedua dari penyair yang berubah menjadi sutradara Yoo Ha. Film ini dirilis pada tanggal 26 April 2002. Pranala luar Marriage is A Crazy Thing di IMDb (dalam bahasa Inggris) Artikel bertopik film Korea Selatan ini a...

 

 

Jonathan Williams

Jonathan Williams Informasi pribadiNama lengkap Jonathan Peter Williams[1]Tanggal lahir 09 Oktober 1993 (umur 30)Tempat lahir Pembury, Kent, InggrisTinggi 5 ft 6 in (1,68 m)Posisi bermain GelandangInformasi klubKlub saat ini Ipswich Town (pinjaman dari Crystal Palace)Nomor 21Karier junior Crystal PalaceKarier senior*Tahun Tim Tampil (Gol)2011– Crystal Palace 55 (0)2014 → Ipswich Town (loan) 13 (1)2014–2015 → Ipswich Town (pinjaman) 5 (1)2015 → Ipswich To...

Pioneer 10

Artikel ini tidak memiliki referensi atau sumber tepercaya sehingga isinya tidak bisa dipastikan. Tolong bantu perbaiki artikel ini dengan menambahkan referensi yang layak. Tulisan tanpa sumber dapat dipertanyakan dan dihapus sewaktu-waktu.Cari sumber: Pioneer 10 – berita · surat kabar · buku · cendekiawan · JSTORPioneer 10 pada fase akhir pembangunannya. Pioneer 10 adalah sebuah wahana antariksa pertama yang melampaui sabuk asteroid, dan juga yang per...

 

 

Provinsi Ancona

Provincia di Ancona Negara  Italia Wilayah / Region Marche Ibu kota Ancona Area 1,940 km2 Population (2008) 474,630 Kepadatan 244.6 inhab./km2 Comuni 49 Nomor kendaraan AN Kode pos 60100 Kode area telepon 071 ISTAT 042 Presiden Patrizia Casagrande Esposto Executive Democratic Party Pemilu terakhir 2009 Peta yang menunjukan lokasi provinsi Ancona di Italia Provinsi Ancona (Italia: Provincia di Anconacode: it is deprecated ) adalah sebuah provinsi di region Marche, di bagian tengah negara...

 

 

Daftar Presiden Nigeria

Muhammadu Buhari Stempel Presiden Republik Federal Nigeria Presiden Nigeria adalah kepala pemerintahan terpilih sekaligus kepala negara di Republik Federal Nigeria. Nama resminya President of the Federal Republic of Nigeria dan Komandan Tertinggi dalam Angkatan Bersenjata Nigeria. Posisi ini, sekarang dijabat Presiden Goodluck Jonathan. Halaman ini menampilkan daftar presiden dan kepala negara Nigeria sejak 1963. Domini Nigeria (1960-1963) Elizabeth II: 1 Oktober 1960 - 1 Oktober 1963 Preside...

Washington's 26th legislative district

Map of Washington's 26th legislative district Washington's 26th legislative district is one of forty-nine districts in Washington state for representation in the state legislature. The district includes southeastern Kitsap Peninsula from Bremerton and Port Orchard in the north to Gig Harbor in the south.[1] The district's legislators are state senator Emily Randall (D) and state representatives Spencer Hutchins (R; position 1) and Michelle Caldier (R; position 2). See also Washington...

 

 

Copa América Centenario broadcasting rights

This article has no lead section. Please improve this article by adding one in your own words. (November 2023) (Learn how and when to remove this template message) CONMEBOL and CONCACAF Country Broadcaster Ref. Latin America DirecTV Sports (All matches)  Argentina Televisión Pública Argentina (Argentina matches only), TyC Sports (all matches) and Multicanal (some matches)  Bolivia TV Boliviana (all matches)  Brazil Rede Globo (Brazil matches only), SporTV (all matches) [1...

 

 

Marwan Dasopang

Ini adalah nama Batak Angkola, marganya adalah Dasopang. H.Marwan Dasopang Anggota Dewan Perwakilan Rakyat Republik IndonesiaPetahanaMulai menjabat 1 Oktober 2014Daerah pemilihanSumatera Utara II Informasi pribadiLahir12 Juni 1962 (umur 61)Pangikiran, Tapanuli Selatan, Sumatera UtaraKebangsaanIndonesiaPartai politikPKBSuami/istriIsmah AmrinaAnak3Alma materIAIN Sumatera UtaraUniversitas KrisnadwipayanaSunting kotak info • L • B Marwan Dasopang (lahir 12 Juni 1962) adalah...

Fernanda Torres

Brazilian actress In this Portuguese name, the first or maternal family name is Pinheiro and the second or paternal family name is Monteiro Torres. Fernanda TorresTorres in 2012BornFernanda Pinheiro Monteiro Torres (1965-09-15) 15 September 1965 (age 58)[1]Rio de Janeiro, BrazilSpouses Pedro Bial ​ ​(m. 1982; div. 1985)​ Gerald Thomas ​ ​(m. 1991; div. 1995)​ Andrucha Waddington...

 

 

María I de Portugal

María I de Portugal Reina de Portugal, Brasil y Algarves Reina del Reino Unido de Portugal Brasil y Algarves 16 de diciembre de 1815-20 de marzo de 1816(95 días)Predecesor Unificación de Portugal y BrasilSucesor Juan VIReina de Portugal y Algarves(junto a Pedro III hasta 1786) 24 de febrero de 1777-16 de diciembre de 1815(38 años y 295 días)Predecesor José ISucesor Unificación con Brasil Otros títulos Reina de Brasil 16 de diciembre de 1815-20 de marzo de 1816(95 días) Pred...

 

 

Konica FT-1

Camera model Konica FT-1OverviewMakerKonishirokuType35 mm SLRLensLens mountKonica ARSensor/mediumFilm speedISO 25 to 3200 [manual]FocusingFocusManualExposure/meteringExposureShutter priority, manualExposure meteringEV0.7 to EV19 @ ASA 100FlashFlashHot shoe, PC socketFlash synchronization1/100 sShutterShutter speed range2 s to 1/1000 sGeneralBattery4 AA or AAADimensions91 × 143 × 46 mmWeight570 gMade inJapan Konica FT-1 with top in silver The Konica FT-1[1] was the last SLR...

George Reid

Australian politician (1845–1918) For other people named George Reid, see George Reid (disambiguation). The Right HonourableSir George ReidGCB GCMG KCReid in 19154th Prime Minister of AustraliaIn office18 August 1904 – 5 July 1905MonarchEdward VIIGovernor‑GeneralLord NorthcotePreceded byChris WatsonSucceeded byAlfred Deakin1st Leader of the OppositionIn office19 May 1901 – 17 August 1904Prime MinisterEdmund BartonAlfred DeakinChris WatsonPreceded byNew p...

 

 

McKesson

Artikel ini sebatang kara, artinya tidak ada artikel lain yang memiliki pranala balik ke halaman ini.Bantulah menambah pranala ke artikel ini dari artikel yang berhubungan atau coba peralatan pencari pranala.Tag ini diberikan pada April 2016. McKessonJenispublik (NYSE: MCK)IndustriKesehatanKantorpusatSan Francisco, CA, Amerika SerikatWilayah operasiSeluruh duniaTokohkunciJohn H. Hammergren(CEO)Situs web[1] McKesson (NYSE: MCK) adalah sebuah perusahaan asal Amerika Serikat yang bergerak di ind...

 

 

Volvo Museum

Museum in Gothenburg, Sweden Previous Volvo Museum The Volvo Museum is situated in Gothenburg, Sweden. It coveres the development of Sweden's leading vehicle manufacturer Volvo, from the first ÖV 4 to their then current cars, trucks, buses and other products. The museum also had displays of Volvo Aero and Volvo Penta products, and many other exhibits, including the joint desk of Assar Gabrielsson and Gustaf Larson from the pioneering years of the company. It is from 2024 part of the exhibiti...

Djoser

DjoserFiraunMasa pemerintahan19 atau 28 tahun kira-kira tahun 2670 SM (Dinasti ke-3)PendahuluKhasekhemwy(paling mungkin)atau NebkaPenggantiSekhemkhet(paling mungkin)atau SanakhteGelar kerajaan Prenomen  (Praenomen) Nisut-Bity-Nebty-Netjerikhetnebunsw.t-bty-nb.ty nṯrj-ẖt-nbwKing of Upper and Lower Egypt, he of the two ladies, with a divine body, the golden one Nomen Nub-HorNbw-ḤrGolden Horus Nama Horus Hor-NetjerikhetHr-nṯrj.ẖtHorus, tubuh ilahi Nama Nebty Netjerikhet Nb.tj Nṯ...

 

 

Insertion device

This article includes a list of general references, but it lacks sufficient corresponding inline citations. Please help to improve this article by introducing more precise citations. (January 2009) (Learn how and when to remove this message) Canted insertion device at the Advanced Photon Source, Argonne National Laboratory. An insertion device (ID) is a component in modern synchrotron light sources, so called because they are inserted into accelerator tracks. They are periodic magnetic struct...

 

 

Four Tops

American vocal quartet Four TopsThe Four Tops in 1968. (L-to-R) Levi Stubbs, Renaldo Obie Benson, Abdul Duke Fakir, and Lawrence PaytonBackground informationAlso known asthe Four Tops, the Four Aims, the TopsOriginDetroit, Michigan, U.S.GenresSoulR&BpopDiscographyFour Tops discographyYears active1953–presentLabelsChessRed TopRiversideColumbiaMotownABC-DunhillCasablancaAristaMembersAbdul Duke FakirRonnie McNeirLawrence Payton Jr. Alexander MorrisPast membersLevi StubbsRenaldo Obie Benson...

Slovenia in the Eurovision Song Contest 2010

Eurovision Song Contest 2010Country SloveniaNational selectionSelection processEMA 2010Selection date(s)Semi-final:20 February 2010Final:21 February 2010Selected entrantAnsambel Žlindra and KalamariSelected songNarodnozabavni rockSelected songwriter(s)Marino LegovičLeon OblakFinals performanceSemi-final resultFailed to qualify (16th)Slovenia in the Eurovision Song Contest ◄2009 • 2010 • 2011► Slovenia participated in the Eurovision Song Contest 20...

 

 

Ecclesiastical Latin

This article is about the version of Latin prevalent throughout Western Christianity. For its use in Christian liturgy, see Liturgical use of Latin. For Latin as a formal lingua franca outside the Church, see Medieval Latin and Neo-Latin. Variety of Latin used by churches Ecclesiastical LatinChurch Latin, Liturgical LatinNative toNever spoken as a native language; other uses vary widely by period and locationExtinctStill used for many purposes, mostly as a liturgical language of the Lati...