The club was founded in 1990 as the result of a merger of two clubs, F.C. Tubize and Amis Réunis de Tubize. At that point it was known as AFC Tubize and last promoted to the first division in 2008, relegating back in 2009. In 2021, the club merged with neighboring Stade Braine from Braine-le-Comte, to form Tubize-Braine, which involved a new logo and a change of colors, from blood red and gold to white and gold.
In 2023–24, Tubize-Braine secure promotion to Belgian National Division 1 from next season after finishing third place in Belgian Division 2 ACFF.
Current squad
As of 24 July 2024:
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.