By the age of six, Scalero was under the tutelage of Pietro Bertazzi, a violinist, musical instrument maker and instructor at the Conservatorio St. Cecilia in Rome.[1] In 1881, Scalero entered the Liceo Musicale di Torino under Luigi Avalle. At the age of 15, Scalero came under the tutelage of César Thomson. Scalero appears to have returned to his home at Moncalieri for a time for health reasons, before returning to Torino (Turin) to study with Camillo Sivori through 1889, appearing during this time with the Sivori Quartet.
In 1891, Scalero made his debut as a recitalist in Leipzig, following which he performed in Milan, Rome, London, and throughout Europe to critical acclaim. In 1895, Scalero went to London to study and assist violinist August Wilhelmj (concert master of the world premiere of Wagner'sRing of the Nibelungs in Bayreuth). In 1900 he left London for Vienna, where he became a composition student of Eusebius Mandyczewski.