1712 (As Prefecture Apostolic of Islands of the Indian Ocean) 1818 (As Prefecture Apostolic of Bourbon) 27 September 1850 (As Diocese of Saint-Denis-de-La Réunion)
Gabriel-Henri-Jérôme de Solages (1829 – 1832.12.08), later first Apostolic Prefect of daughter jurisdiction South Seas Islands (New Zealand) (1830 – 1832.12.08)
Exempt Bishops of Saint-Denis-de-La Réunion
Florian Desprez (1850.06.22 – 1857.03.19), later Bishop of Limoges (France) ([1857.02.04] 1857.03.19 – 1859.09.26), Metropolitan Archbishop of Toulouse (France) ([1859.07.30] 1859.09.26 – death 1895.01.21), created Cardinal-Priest of Ss. Marcellino e Pietro (1879.09.22 – 1895.01.21)
Armand-René Maupoint (1857.02.14 – 1871.07.10), later Apostolic Prefect of daughter jurisdiction Zanguebar (Zanzibar island, now in Tanzania) (1862 – death 1871.07.10)
Gilbert Guillaume Marie-Jean Aubry (since 1975.11.20 – retired 2023.07.19), also President of Episcopal Conferences of Indian Ocean (1989–1996), Apostolic Administrator of neighbouring Indian Ocean diocese Port Victoria (Seychelles) (1994 – 1995.03.03), President of Episcopal Conferences of Indian Ocean (2002–2006)
Pascal David Youri Chane-Teng (since 2023.07.19 - )