The first bishop to be appointed, in 1561, was Remi Drieux (Remigius Driutius), who never took possession of his see. Despite this, in October 1565, Dreux did take part in the provincial council of Utrecht as bishop of Leeuwarden.[2] In 1569 Drieux was appointed to the diocese of Bruges, and was succeeded in Leeuwarden by Cunerus Petri.
In 1578, during the Dutch Revolt, part of the Eighty Years War (when Catholic Habsburg lost the northern provinces), bishop Petri was captured by the rebel stadtholder (governor) of Friesland, George de Lalaing, Count of Rennenberg, and imprisoned in Harlingen. The bishop was to die in exile in Germany in 1580. In 1579 Rennenberg sequestered the revenues of the diocese, and transferred them to the States of Friesland. The diocese was legally suppressed, along with Catholic worship, in 1580.[3] From 1592 the diocesan territory was ecclesiastically part of the Dutch Mission.