Rimegepant, sold under the brand name Nurtec ODT among others, is a medication used for the acute treatment of migraine with or without aura in adults and the prophylactic/ preventive treatment of episodic migraine in adults.[8][10] It is taken by mouth to dissolve on or under the tongue.[8] It works by blocking CGRP receptors.[11]
In the United States, rimegepant was approved for treating acute migraine in February 2020,[12] and its approval was extended to preventing episodic migraine in June 2021.[8] It is produced and marketed by Pfizer.[13] In March 2021, rimegepant was approved for medical use in the United Arab Emirates and in Israel.[14][15] It was approved for medical use in Canada in December 2023.[4] In the United Kingdom, rimegepant is approved by NICE for the prophylaxis and treatment of acute migraine in adults.[16]
Medical uses
Rimegepant is indicated for the treatment of acute migraine with or without aura in adults and for the preventative treatment of episodic migraine in adults.[8][10][9]
Rimegepant was developed by Biohaven Pharmaceuticals, which markets the drug in the United States after receiving FDA approval in February 2020.[12][17] Approval was based on evidence from one clinical trial of 1,351 subjects with migraine headaches.[10]
Society and culture
Legal status
On 24 February 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Vydura, intended for the prophylaxis and acute treatment of migraine.[18] The applicant for this medicinal product is Biohaven Pharmaceutical Ireland DAC.[18] Rimegepant was approved for medical use in the European Union in April 2022.[9][19]
References
^ ab"Nurtec ODT". Therapeutic Goods Administration (TGA). 8 August 2023. Archived from the original on 11 October 2023. Retrieved 10 September 2023.
^ ab"Archived copy"(PDF). Archived(PDF) from the original on 3 March 2024. Retrieved 10 March 2024.{{cite web}}: CS1 maint: archived copy as title (link)
^ abc"Vydura EPAR". European Medicines Agency (EMA). 22 February 2022. Archived from the original on 16 October 2022. Retrieved 11 May 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
^ abDiener HC, Charles A, Goadsby PJ, Holle D (October 2015). "New therapeutic approaches for the prevention and treatment of migraine". The Lancet. Neurology. 14 (10): 1010–1022. doi:10.1016/S1474-4422(15)00198-2. PMID26376968. S2CID26523013.
^ ab"Vydura: Pending EC decision". European Medicines Agency (EMA). 24 February 2022. Archived from the original on 27 February 2022. Retrieved 27 February 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
