She married Ejaz Rehman (spelling variants include Ijaz), her first cousin and a British psychiatrist, when she was 19. Following their divorce, Khan began working as a broadcast journalist.[1] She has three children who have lived with her since the divorce.[16][17][18]
On 6 January 2015, Imran Khan confirmed his marriage to Reham which ended on 30 October 2015 in a divorce.[5][19][20]
On 2 January 2022, Khan revealed on Twitter that she had narrowly escaped a gun attack in Islamabad when returning home from her nephew's wedding. She said her car was shot at and two men on a motorcycle and they held the vehicle at gunpoint.[21]
In 2013, Khan came to Pakistan and joined Pakistani news channel News One (Pakistani TV channel). She later joined Aaj TV. In 2014, following a brief stint at PTV, she joined Dawn News presenting the current affairs show In Focus. Following a brief hiatus in early 2015, she resumed her work with a new show on Dawn. The Reham Khan Show, a programme celebrating Pakistani heroes, debuted in May 2015.[23] In December 2015, she started a new talk show by the name of Tabdeeli on Neo TV. Tabdeeli (change) is also a political slogan of Imran Khan, her former husband.[24] Reham left Neo TV in June 2016.
Reham has also produced a Pakistani film Janaan, the romantic comedy set in Swat which premiered on the occasion of Eid ul Adha on 13 September 2016.[25]
^"Reham Khan's book 'available in paperback in UK'". The News (Pakistan). 12 July 2018. Reham's book, published online today, has triggered debate on social media with many saying that she is doing all this on the behest of Pakistan Muslim League Nawaz to tarnish the image of Pakistan Tehreek-e-Insaf Chairman Imran Khan just before the July 25 polls.