Spanish settlement in the area that became the municipality began in 1617 with the founding of a Franciscan mission by Fr. Juan Bautista Mollinedo and Fr. Juan de Cárdenas, The mission was called "San Felipe de los Gamotes".[1] The mission was abandoned as the local Indians died out or fled to the mountains.[2]
On 8 October 1827 the town of Nuevo Gamotes was formally established.[3][2]