A Karay·a,[3] Muzones was born in Iloilo City[1] and was the oldest of ten children of Santiago Muzones and Florentina Larupay. He received his law degree at Central Philippine University in 1952. He wrote 62 novels in the course of his life, the first of which was Tibud nga Bulawan in 1938.[4] He was a founder of an organization for Hiligaynon writers called Sumakwelan.[2][5]
Muzones' awards included the Gawad Bonifacio sa Panitikan Centennial Award given by the National Commission for Culture and the Arts (1997).[2] In 2018 he was honored as an Ilonggo National Artist of the Philippines for Literature.[7]