The station is named after Vine Street, which today acts as frontage roads along Interstate 676 and nearby Race Street, although the given address is closer to westbound Vine than Race. This stop is also used as the official stop for the Pennsylvania Convention Center on the Broad Street Line; signs will direct passengers to the appropriate exits. However, riding the Broad Street Line one stop further south to City Hall and then connecting to the Market–Frankford Line East toward Frankford and then exiting at 11th Street station will bring passengers right inside the Pennsylvania Convention Center and the Fashion District.
Passengers may connect to SEPTA City Bus Routes 4, 16, and 27 here, in addition to a number of NJ Transit bus routes, which board on the northeast corner of Broad and Vine Streets. Until the mid-1990s, there was a concourse leading up Broad Street from City Hall to the Race Street side of the station.