Rabbit hemorrhagic disease

Rabbit hemorrhagic disease virus
CryoEM reconstruction of the virus capsid. EMDB entry EMD-1933[2]
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Picornavirales
Family: Caliciviridae
Genus: Lagovirus
Species:
Rabbit hemorrhagic disease virus
Isolates[1]
  • RHDV [FRG/89] (RHDV-FRG)
  • RCV [ITL/95] (RHDV-RCV)
  • RCV-A1 [MIC-07/2007/AU] (RHDV-RCV-A1)
  • RHDV [Ashington/1998/UK] (RHDV-Ash)
Synonyms
  • Lagovirus europeus GI
    Pendu et al., 2017[3]
Rabbit Calicivirus CSIRO

Rabbit hemorrhagic disease (RHD), also known as viral hemorrhagic disease (VHD), is a highly infectious and lethal form of viral hepatitis that affects European rabbits. Some viral strains also affect hares and cottontail rabbits. Mortality rates generally range from 70 to 100 percent.[4] The disease is caused by strains of rabbit hemorrhagic disease virus (RHDV), a lagovirus in the family Caliciviridae.

Rabbit hemorrhagic disease virus

Rabbit hemorrhagic disease virus (RHDV) is a virus in the genus Lagovirus and the family Caliciviridae. It is a nonenveloped virus with a diameter around 35–40 nm, icosahedral symmetry, and a linear positive-sense RNA genome of 6.4–8.5 kb. RHDV causes a generalized infection in rabbits that is characterized by necrosis of the liver, disseminated intravascular coagulation, and rapid death. Division into serotypes has been defined by a lack of cross-neutralization using specific antisera.[5] Rabbit lagoviruses also include related caliciviruses such as European brown hare syndrome virus.[6]

RHDV appears to have evolved from a pre-existing avirulent rabbit calicivirus (RCV). Nonpathogenic rabbit caliciviruses related to, but distinct from RHDV, had been circulating, apparently harmlessly, in Europe, Australia, and New Zealand prior to the emergence of RHDV.[7][8] In the course of its evolution, RHDV split into six distinct genotypes, all of which are highly pathogenic.[8]

The three strains of rabbit hemorrhagic disease virus of medical significance are RHDV, RHDVa and RHDV2. RHDV (also referred to as RHDV, RHDV1, or as classical RHD) only affects adult European rabbits (Oryctolagus cuniculus). This virus was first reported in China in 1984,[9] from which it spread to much of Asia, Europe, Australia, and elsewhere.[10] A few isolated outbreaks of RHDV have occurred in the United States and Mexico, but they remained localized and were eradicated.[citation needed]

In 2010, a new lagovirus with a distinct antigenic profile was identified in France. The new virus, named rabbit hemorrhagic disease virus type 2 (abbreviated as RHDV2 or RHDVb), also caused RHD, but exhibited distinctive genetic, antigenic, and pathogenic features. Importantly, RHDV2 killed rabbits previously vaccinated with RHDV vaccines, and affected young European rabbits, as well as hares (Lepus spp.).[11] All these features strongly suggest that the virus was not derived from RHDVa, but from some other unknown source.[4] RHDV2 has since spread to the majority of Europe, as well as to Australia, Canada,[12] and the United States.[13][14]

Epidemiology and transmission

Both viruses causing RHD are extremely contagious. Transmission occurs by direct contact with infected animals, carcasses, bodily fluids (urine, feces, respiratory secretions), and hair. Surviving rabbits may be contagious for up to 2 months.[6] Contaminated fomites such as clothing, food, cages, bedding, feeders, and water also spread the virus. Flies, fleas, and mosquitoes can carry the virus between rabbits.[10] Predators and scavengers can also spread the virus by shedding it in their feces.[10] Caliciviruses are highly resistant in the environment, and can survive freezing for prolonged periods. The virus can persist in infected meat for months, and for prolonged periods in decomposing carcasses. Importation of rabbit meat may be a major contributor in the spread of the virus to new geographic regions.[6]

RHD outbreaks tend to be seasonal in wild rabbit populations, where most adults have survived infection and are immune. As young kits grow up and stop nursing, they no longer receive the antibodies provided in their mother's milk and become susceptible to infection. Thus, RHD epizootics occur more often during the rabbits' breeding season.[10]

Generally, high host specificity exists among lagoviruses.[6] Classic RHDVa only affects European rabbits, a species native to Europe and from which the domestic rabbit is descended. The new variant RHDV2 affects European rabbits, as well, but also causes fatal RHD in various Lepus species, including Sardinian Cape hares (L. capensis mediterraneus), Italian hares (L. corsicanus), and mountain hares (L. timidus).[15] Reports of RHD in Sylvilagus species have been coming from the current outbreak in the United States.[16]

RHD caused by RHDV and RHDVa demonstrates high morbidity (up to 100%) and mortality (40-100%) in adult European rabbits. Young rabbits 6–8 weeks old are less likely to be infected, and kits younger than 4 weeks old do not become ill.[6] The more recently emerged RHDV2 causes death and disease in rabbits as young as 15 days old. Mortality rates from RHDV2 are more variable at 5-70%. Initially less virulent, the pathogenicity of RHDV2 has been increasing and is now similar to that found with RHDV and RHDVa. Deaths from RHDV2 have been confirmed in rabbits previously vaccinated against RHDVa.[6]

Pathophysiology

These viruses replicate in the liver and by mechanisms not fully elucidated, trigger the mass death of hepatocytes which can in turn lead to disseminated intravascular coagulation, hepatic encephalopathy, and nephrosis.[10] Bleeding may occur, as clotting factors and platelets are used up.

Clinical signs

European rabbit with ocular jaundice

The incubation period for RHDVa is 1–2 days, and for RHDV2 3–5 days. Rabbits infected with RHDV2 are more likely to show subacute or chronic signs than are those infected with RHDVa.[6] In rabbitries, an epidemic with high mortality rates in adult and subadult rabbits is typical.[10] If the outbreak is caused by RHDV2, then deaths also occur in young rabbits.[citation needed]

RHD can vary in the rate clinical signs occur. In peracute cases, rabbits are usually found dead with no premonitory symptoms.[15] Rabbits may be observed grazing normally immediately before death.[10]

In acute cases, rabbits are inactive and reluctant to move. They may develop a fever up to 42 °C (107.6 °F) and have increased heart and respiratory rates. Bloody discharge from the nose, mouth, or vulva is common, as is blood in the feces or urine. Lateral recumbency, coma, and convulsions may be observed before death.[10] Rabbits with the acute form generally die within 12 to 36 hours from the onset of fever.[15]

Subacute to chronic RHD has a more protracted clinical course, and is more commonly noted with RHDV2 infections. Clinical signs include lethargy, anorexia, weight loss, and jaundice. Gastrointestinal dilation, cardiac arrhythmias, heart murmurs, and neurologic abnormalities can also occur.[6] Death, if it occurs, usually happens 1–2 weeks after the onset of symptoms, and is due to liver failure.[15]

Not all rabbits exposed to RHDVa or RHDV2 become overtly ill. A small proportion of infected rabbits clears the virus without developing signs of disease.[10] Asymptomatic carriers also occur, and can continue to shed virus for months, thereby infecting other animals. Surviving rabbits develop a strong immunity to the specific viral variant with which they were infected.[6]

Diagnosis

A presumptive diagnosis of RHD can often be made based on clinical presentation, infection pattern within a population, and post mortem lesions. Definitive diagnosis requires detection of the virus. As most caliciviruses cannot be grown in cell culture, antibody and nucleic acid based methods of viral detection are often used.[6]

Complete blood counts from rabbits with RHD often show low levels of white blood cells and platelets, and chemistry panels show elevated liver enzymes. Evidence of liver failure may also be present, including increased bile acids and bilirubin, and decreased glucose and cholesterol. Prolonged prothrombin and activated partial thromboplastin times are typical. Urinalysis can show bilirubinuria, proteinuria, and high urinary GGT.[6]

The classic post mortem lesion seen in rabbits with RHD is extensive hepatic necrosis. Multifocal hemorrhages, splenomegaly, bronchopneumonia, pulmonary hemorrhage or edema, and myocardial necrosis may sometimes also be seen.[6]

RT-qPCR tests are a commonly used and accurate testing modality for RNA-based viruses. Other tests used include enzyme-linked immunosorbent assay, electron microscopy, immunostaining, Western blot, and in situ hybridization.[6] The tissue of choice for molecular testing is fresh or frozen liver, as it usually contains the largest numbers of virus, but if this is not available, spleen and serum can also be used. Identification of the strain of RHDV is needed so vaccination protocols can be adjusted accordingly.[citation needed]

Prevention and control

Vaccines

A number of vaccines available against RHD are sold in countries where the disease is endemic. All provide 12 months of protection against RHD viruses. Because RHD viruses cannot normally be grown in vitro,[17] how these vaccines are produced is affected. Inactivated RHD vaccines, including Eravac,[18] Felavac, and Cylap, are "liver-derived", meaning that laboratory rabbits are intentionally infected with RHD and their livers and spleens harvested to make vaccines. Each rabbit used results in the production of thousands of vaccine doses. This has led to controversy among rabbit lovers, who question the ethics of some rabbits having to die to protect others[19] but is not an issue where rabbits are primarily farmed for meat. Another method of reproducing the virus is through recombinant technology, where antigenic portions of the RHD viruses are inserted into viruses that can be grown in culture. This is the method used to create Nobivac Myxo-RHD PLUS.[20]

Vaccines against only the classic RHDVa strain are: Cylap RCD Vaccine, made by Zoetis,[21] protects rabbits from two different strains of RHDVa (v351 and K5) that are used for wild rabbit control in Australia.[22] CUNIPRAVAC RHD,[23] manufactured by HIPRA, protects against the RHDVa strains found in Europe. Nobivac Myxo-RHD,[24] made by MSD Animal Health, is a live myxoma-vectored vaccine that offers one-year duration of immunity against both RHDVa and myxomatosis.[citation needed]

Vaccines against only the newer RHDV2 strain are: Eravac vaccine, manufactured by HIPRA,[25] protects rabbits against RHDV2 for a year.

Vaccines that protect against both RHDVa and RHDV2 strains include: Filavac VHD K C+V,[26] manufactured by Filavie, protects against both classical RHDVa and RHDV-2.[27] It is available in single dose and multidose vials. A soon-to-be-released vaccine from MSD Animal Health, Nobivac Myxo-RHD PLUS, is a live recombinant vector vaccine active against both RHDVa and RHDV2, as well as myxomatosis.[28]

Countries in which RHD is not considered endemic may place restrictions on importation of RHDV vaccines. Importation of these vaccines into the United States can only be done with the approval of the United States Department of Agriculture[29] and the appropriate state veterinarian.[30]

Disinfection

Caliciviruses are stable in the environment and difficult to inactivate. Products commonly used for household disinfection such as Clorox and Lysol disinfecting wipes do not work against these viruses. One effective option is to wipe down surfaces with a 10% bleach solution, allowing 10 minutes of contact time before rinsing. Other disinfectants shown to work include 10% sodium hydroxide, 2% One-Stroke Environ, Virkon S, Clorox Healthcare Bleach Germicidal Wipes, Trifectant, Rescue, and hydrogen peroxide cleaners. Surface debris must always be mechanically removed prior to disinfection. A list of disinfectants that are effective against calicivirus (in this case norovirus) can be found on the Environmental Protection Agency's website.[31] Studies have shown that many quaternary ammonium compound based disinfectants do not inactivate caliciviruses.[32]

Quarantine and other measures

Because of the highly infectious nature of the disease, strict quarantine is necessary when outbreaks occur. Depopulation, disinfection, vaccination, surveillance, and quarantine are the only way to properly and effectively eradicate the disease. Deceased rabbits must be removed immediately and discarded in a safe manner. Surviving rabbits should be quarantined or humanely euthanized. Test rabbits may be used to monitor the virus on vaccinated farms.[33]

Geographic distribution

RHD is primarily a disease affecting European rabbits, which are native to the Iberian Peninsula and are found in the wild in much of Western Europe. Domesticated breeds are farmed throughout the world for meat and fur, and are becoming increasingly popular pets. European rabbits have been introduced to and become feral and sometimes invasive in Australia, New Zealand, Chile, Argentina, and various islands.[8]

RHD was first reported in 1984 in the People's Republic of China. Since then, RHD has spread to over 40 countries in Africa, the Americas, Asia, Europe, and Oceania, and is endemic in most parts of the world.[34]

In 2010, a new virus variant called rabbit hemorrhagic disease virus 2 (RHDV2) emerged in France.[35] RHDV2 has since spread from France to the rest of Europe, Great Britain, Australia, and New Zealand. Outbreaks started occurring in the United States and Vancouver Island Canada in 2019.

Asia

China

The first reported outbreak of RHD caused by RHDVa occurred in 1984 in the Jiangsu Province of the Mainland China.[9] The outbreak occurred in a group of Angora rabbits that had been imported from Germany. The cause of the disease was determined to be a small, nonenveloped RNA virus. An inactivated vaccine was developed that proved effective in preventing disease.[9] In less than a year, the disease spread over an area of 50,000 km2 in China and killed 140 million domestic rabbits.[36]

South Korea

South Korea was the next country to report RHD outbreaks following the importation of rabbit fur from Mainland China.[36][37] RHD has since spread to and become endemic in many countries in Asia, including India and the Middle East.[citation needed]

Europe

From China, RHDVa spread westward to Europe. The first report of RHD in Europe came from in Italy in 1986.[36] From there, it spread to much of Europe. Spain's first reported case was in 1988,[36] and France, Belgium, and Scandinavia followed in 1990. Spain experienced a large die-off of wild rabbits, which in turn caused a population decline in predators that normally ate rabbits, including the Iberian lynx and Spanish imperial eagle.[38][39]

United Kingdom

RHD caused by RHDVa was reported for the first time in the United Kingdom in 1992.[40] This initial epidemic was brought under control in the late 1990s using a combination of vaccination, strict biosecurity, and good husbandry.[15] The newer viral strain RHDV2 was first detected in England and Wales in 2014, and soon spread to Scotland and Ireland.[15]

Finland

RHD was detected for the first time in Finland in 2016. The outbreak occurred in feral European rabbits, and genetic testing identified the viral strain as RHDV2. Cases of viral transmission to domesticated pet rabbits have been confirmed, and vaccinating rabbits has been recommended.[41]

Oceania

Australia

In 1991, a strain of the RHDVa virus, Czech CAPM 351RHDV, was imported to Australia[42] under strict quarantine conditions to research the safety and usefulness of the virus if it were used as a biological control agent against Australia and New Zealand's rabbit pest problem. Testing of the virus was undertaken on Wardang Island in Spencer Gulf off the coast of the Yorke Peninsula, South Australia. In 1995, the virus escaped quarantine and subsequently killed 10 million rabbits within 8 weeks of its release.[43] In March 2017, a new Korean strain known as RHDV K5 was successfully released in a deliberate manner after almost a decade of research. This strain was chosen in part because it functions better in cool, wet regions where the previous Calicivirus was less effective.[44]

New Zealand

In July 1997, after considering over 800 public submissions, the New Zealand Ministry of Health decided not to allow RHDVa to be imported into New Zealand to control rabbit populations. However, in late August, RHDVa was confirmed to have been deliberately and illegally introduced to the Cromwell area of the South Island. An unsuccessful attempt was made by New Zealand officials to control the spread of the disease. It was, however, being intentionally spread, and several farmers (notably in the Mackenzie Basin area) admitted to processing rabbits that had died from the disease in kitchen blenders for further spreading. Had the disease been introduced at a better time, control of the population would have been more effective, but it was released after breeding had commenced for the season, and rabbits under 2 weeks old at the time of the introduction were resistant to the disease. These young rabbits were, therefore, able to survive and breed rabbit numbers back up. Ten years on, rabbit populations (in the Mackenzie Basin in particular) are beginning to reach near preplague proportions once again, though they have not yet returned to pre-RHD levels.[45][46] Resistance to RHD in New Zealand rabbits has led to the widespread use of Compound 1080 (Sodium fluoroacetate). The government and department of conservation are having to increase their use of 1080 to protect reserve land from rabbits and preserve the gains made in recent years through the use of RHD.[47]

North and South America

United States and Canada

Isolated outbreaks of RHDVa in domestic rabbits have occurred in the United States, the first of which was in Iowa in 2000.[48] In 2001, outbreaks occurred in Utah, Illinois, and New York.[49][50][51] More recent outbreaks of RHDVa have occurred in 2005 in Indiana and 2018 in Pennsylvania.[52][53] Each of these outbreaks was contained and was the result of separate but indeterminable introductions of RHDVa.[10] RHDVa does not affect the native cottontail and jackrabbits in the United States, so the virus did not become endemic.[33]

The first report of RHDV2 virus in North America was on a farm in Québec, in 2016. In 2018, a larger outbreak occurred in feral European rabbits on Delta and Vancouver Island, British Columbia.[54] The disease was confirmed later that year in a pet rabbit in Ohio.[55] In July 2019, the first case of RHDV2 in Washington was confirmed in a pet rabbit from Orcas Island.[56] RHDV2 have been reported in domestic rabbits in Washington and New York.[citation needed]

In 2020, outbreaks of the disease in domestic rabbits, as well as cottontail rabbits and hares, have been reported in Arizona, New Mexico, Colorado, Texas, Nevada, California and Utah.[57] Affected wildlife include mountain cottontail rabbits (Sylvilagus nutalli), desert cottontail rabbits (S. audubonii), antelope jackrabbits (L. alleni), and black-tailed jackrabbits (L. californicus).[58] The virus circulating in the Southwest United States is distinct from the RHDV2 isolated from New York, Washington, Ohio, and British Columbia, Canada.[58] The sources of these outbreaks are unknown.[58]

In June 2022, a case occurred in Hawaii. It was first confirmed in a neutered hare on Maui. Department of Agriculture inspectors began testing after becoming aware of 9 rabbit deaths on a Maui farm.[59]

Mexico

Mexico experienced an outbreak of RHDVa in domestic rabbits from 1989 to 1991, presumably following the importation of rabbit meat from the People's Republic of China.[60] Strict quarantine and depopulation measures were able to eradicate the virus, and the country was officially declared to be RHD-free in 1993.[61]

A second outbreak of RHD in domestic rabbits began in the state of Chihuahua in April 2020 and has since spread to Sonora, Baja California, Baja California Sur, Coahuila, and Durango.[62] As of 2021 and 2022, a RHD outbreak occurred in Hidalgo and the Mexico City Metropolitan Area.[63][64] A mass disinfectant and vaccination campaign was ordered by the Directorate of Agricultural Development and over 390 thousand rabbits have received vaccinations.[65][66] It has been confirmed ever since then, that the disease is present In Central Mexico.[67]

Cuba

Since 1993, RHDVa has been endemic in Cuba. Four epizootics involving domesticated rabbits were reported in 1993, 1997, 2000–2001, and 2004–2005. As consequence, thousands of rabbits have died or have been slaughtered each time.[68]

Bolivia

The virus is also believed to be present in Bolivia.[citation needed]

See also

References

  1. ^ "ICTV 9th Report (2011) Caliciviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 9 January 2019.[dead link‍]
  2. ^ Luque, D; González, JM; Gómez-Blanco, J; et al. (2012). "Epitope Insertion at the N-Terminal Molecular Switch of the Rabbit Hemorrhagic Disease Virus T=3 Capsid Protein Leads to Larger T=4 Capsids". Journal of Virology. 86 (12): 6470–6480. doi:10.1128/JVI.07050-11. PMC 3393579. PMID 22491457.
  3. ^ Le Pendu, J.; et al. (2017). "Proposal for a unified classification system and nomenclature of lagoviruses". The Journal of General Virology. 98 (7): 1658–1666. doi:10.1099/jgv.0.000840. PMID 28714849.
  4. ^ a b Capucci, L; Cavadini, P; Schiavitto, M; et al. (2017). "Increased pathogenicity in rabbit haemorrhagic disease virus type 2 (RHDV2)". Veterinary Record. 180 (17): 426. doi:10.1136/vr.104132. PMID 28341721.
  5. ^ "Caliciviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 4 May 2020.
  6. ^ a b c d e f g h i j k l m Gleeson, M; Petritz, OA (May 2020). "Emerging Infectious Diseases of Rabbits". Veterinary Clinics of North America: Exotic Animal Practice. 23 (2): 249–261. doi:10.1016/j.cvex.2020.01.008. PMID 32327034. S2CID 216109069.
  7. ^ Capucci, L; Fusi, P; Lavazza, A; et al. (December 1996). "Detection and preliminary characterization of a new rabbit calicivirus related to rabbit hemorrhagic disease virus but nonpathogenic". Journal of Virology. 70 (12): 8614–8623. doi:10.1128/JVI.70.12.8614-8623.1996. PMC 190954. PMID 8970986.
  8. ^ a b c Kerr, PJ; Kitchen, A; Holmes, EC (2009). "Origin and Phylodynamics of Rabbit Hemorrhagic Disease Virus". Journal of Virology. 83 (23): 12129–12138. doi:10.1128/JVI.01523-09. PMC 2786765. PMID 19759153.
  9. ^ a b c Liu, SJ; Xue, HP; Pu, BQ; et al. (1984). "A new viral disease in rabbits". Animal Husbandry and Veterinary Medicine (Xumu Yu Shouyi). 16 (6): 253–255.
  10. ^ a b c d e f g h i j Kerr, PJ; Donnelly, TM (May 2013). "Viral Infections of Rabbits". Veterinary Clinics of North America: Exotic Animal Practice. 16 (2): 437–468. doi:10.1016/j.cvex.2013.02.002. PMC 7110462. PMID 23642871.
  11. ^ Bárcena, J; Guerra, B; Angulo, I; et al. (2015). "Comparative analysis of rabbit hemorrhagic disease virus (RHDV) and new RHDV2 virus antigenicity, using specific virus-like particles". Veterinary Research. 46 (1): 106. doi:10.1186/s13567-015-0245-5. PMC 4581117. PMID 26403184.
  12. ^ Ambagala, Aruna; Schwantje, Helen; Laurendeau, Sonja; Snyman, Heindrich; Joseph, Tomy; Pickering, Bradley; Hooper-McGrevy, Kathleen; Babiuk, Shawn; Moffat, Estella; Lamboo, Lindsey; Lung, Oliver; Goolia, Melissa; Pinette, Mathieu; Embury-Hyatt, Carissa (2021-05-26). "Incursions of rabbit haemorrhagic disease virus 2 in Canada—Clinical, molecular and epidemiological investigation". Transboundary and Emerging Diseases. 68 (4): 1711–1720. doi:10.1111/tbed.14128. ISSN 1865-1674. PMID 33915034.
  13. ^ "Rabbit hemorrhagic disease". American Veterinary Medical Association. Retrieved 2022-08-07.
  14. ^ "Deadly rabbit disease confirmed in Thurston County; vets urge vaccination". Washington State Department of Agriculture. 2020-09-25. Retrieved 2022-08-07.
  15. ^ a b c d e f Rocchi, MS; Dagleish, MP (2018). "Diagnosis and prevention of rabbit viral haemorrhagic disease 2". In Practice. 40 (1): 11–16. doi:10.1136/inp.k54. S2CID 80154118.
  16. ^ Fiala, Jennifer (2 August 2008). "Southwest US faces lethal rabbit disease outbreak". Vin.com. Retrieved 21 April 2020.
  17. ^ Zhu, J; Miao, Q; Tan, Y; et al. (2017). "Inclusion of an Arg-Gly-Asp receptor-recognition motif into the capsid protein of rabbit hemorrhagic disease virus enables culture of the virus". Journal of Biological Chemistry. 292 (21): 8605–8615. doi:10.1074/jbc.M117.780924. PMC 5448090. PMID 28381555.
  18. ^ "CVMP assessment report for ERAVAC" (PDF). Committee for Medicinal Products for Veterinary Use, European Medicines Agency. Retrieved 1 May 2020.
  19. ^ "HRS RHDV2 Vaccine Ethics Statement | House Rabbit Society". House Rabbit Society. Archived from the original on 2020-05-16. Retrieved 1 May 2020.
  20. ^ Francisco, EM (13 September 2019). "Nobivac Myxo-RHD Plus". European Medicines Agency. Retrieved 1 May 2020.
  21. ^ "Cylap RCD Vaccine". www.zoetis.com.au. Retrieved 25 April 2020.
  22. ^ Read, AJ; Kirkland, PD (July 2017). "Efficacy of a commercial vaccine against different strains of rabbit haemorrhagic disease virus". Australian Veterinary Journal. 95 (7): 223–226. doi:10.1111/avj.12600. PMID 28653381. S2CID 5123892.
  23. ^ "CUNIPRAVAC RHD". HiPRA. Retrieved 25 April 2020.
  24. ^ "Nobivac Myxo RHD | Overview". MSD Animal Health. Retrieved 26 April 2020.
  25. ^ "Eravac". NOAH Compendium. Retrieved 26 April 2020.
  26. ^ "Filavac VHD K C+V". NOAH Compendium. Retrieved 26 April 2020.
  27. ^ Le Minor, O.; Boucher, S.; Joudou, L.; Mellet, R.; Sourice, M.; Le Moullec, T.; Nicolier, A.; Beilvert, F.; Sigognault-Flochlay, A. (2019). "Rabbit haemorrhagic disease: experimental study of a recent highly pathogenic GI.2/RHDV2/b strain and evaluation of vaccine efficacy". World Rabbit Science. 27 (3): 143. doi:10.4995/wrs.2019.11082. hdl:10251/126955.
  28. ^ "Nobivac Myxo-RHD PLUS". NOAH Compendium. Retrieved 26 April 2020.
  29. ^ "APHIS Form 2005" (PDF). USDA APHIS. Retrieved 26 April 2020.
  30. ^ "State Animal Health Officials" (PDF). USAHA. Retrieved 26 April 2020.
  31. ^ "EPA's registered antimicrobial products effective against Norovirus". US Environmental Protection Agency. 28 September 2015. Retrieved 12 May 2020.
  32. ^ Kennedy, MA; Mellon, VS; Caldwell, G; et al. (1995). "Virucidal efficacy of the newer quaternary ammonium compounds". Journal of the American Animal Hospital Association. 31 (3): 254–258. doi:10.5326/15473317-31-3-254. PMID 7634062.
  33. ^ a b Spickler, Anna. "Rabbit Hemorrhagic Disease" (PDF). The Center for Food Security and Public Health. Retrieved 27 April 2020.
  34. ^ "Rabbit haemorrhagic disease" (PDF). OIE Technical Disease Cards. Retrieved 27 April 2020.
  35. ^ Le Gall-Reculé, G; Lavazza, A; Marchandeau, S; et al. (2013). "Emergence of a new lagovirus related to rabbit haemorrhagic disease virus". Veterinary Research. 44 (1): 81. doi:10.1186/1297-9716-44-81. PMC 3848706. PMID 24011218.
  36. ^ a b c d Abrantes, J; van der Loo, W; Le Pendu, J; et al. (2012). "Rabbit haemorrhagic disease (RHD) and rabbit haemorrhagic disease virus (RHDV): a review". Veterinary Research. 43 (1): 12. doi:10.1186/1297-9716-43-12. PMC 3331820. PMID 22325049.
  37. ^ Lee, CS; Park, CK; Shin, TK; et al. (1990). "An outbreak of rabbit sudden death in Korea suspected of a new viral hepatitis". The Japanese Journal of Veterinary Science. 52 (5): 1135–1137. doi:10.1292/jvms1939.52.1135. PMID 2280498.
  38. ^ "Iberian Lynx Depends On Rabbits for Survival". Science Daily. 5 July 2011.
  39. ^ Platt, JR (12 July 2011). "Deadly Rabbit Disease May Have Doomed Iberian Lynx". Scientific American.
  40. ^ Chasey, D (1994). "Possible origin of rabbit haemorrhagic disease in the United Kingdom". Veterinary Record. 135 (21): 469–499. doi:10.1136/vr.135.21.496 (inactive 2024-11-14). PMID 7871688. S2CID 32592717.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
  41. ^ Isomursu, M; Neimanis, A; Karkamo, V; et al. (2018). "An Outbreak of Rabbit Hemorrhagic Disease in Finland". Journal of Wildlife Diseases. 54 (4): 838–842. doi:10.7589/2017-11-286. PMID 29889007. S2CID 47009417.
  42. ^ Cooke, BD (2014). Australia's War Against Rabbits. CSIRO Publishing. ISBN 9780643096127.
  43. ^ Strive, T (2008). "Rabbit Calicivirus Disease (RCD)". Commonwealth Scientific and Industrial Research Organisation. Archived from the original (pdf) on April 15, 2014. Retrieved 14 April 2014.
  44. ^ Adams, P (1 April 2017). "K5 rabbit virus an early success, researchers say". ABC News. Retrieved 2018-05-20.
  45. ^ Munro, Robert K.; Williams, Richard T., eds. (1994). Rabbit Haemorrhagic Disease: Issues in Assessment for biological control. Canberra: Bureau of Resource Sciences. ISBN 9780644335126.
  46. ^ Williams, D (26 May 2009). "Plan for 1080 drops in MacKenzie Basin". The Press. Retrieved 2009-06-14.
  47. ^ "Welcome to 1080: The Facts". 1080facts.co.nz. Archived from the original on 2016-06-16. Retrieved 2013-12-05.
  48. ^ "Rabbit calicivirus infection confirmed in Iowa rabbitry". www.avma.org. American Veterinary Medical Association. May 2000. Retrieved 22 June 2019.
  49. ^ "Viral Hemorrhagic Disease of Rabbits_ Utah 8_28_01". www.aphis.usda.gov. Animal and Plant Health Inspection Service. Retrieved 22 June 2019.
  50. ^ Campagnolo, ER; Ernst, MJ; Berniger, ML; et al. (October 2003). "Outbreak of rabbit hemorrhagic disease in domestic lagomorphs". Journal of the American Veterinary Medical Association. 223 (8): 1151–5. doi:10.2460/javma.2003.223.1151. PMID 14584745.
  51. ^ "Rabbit Hemorrhagic Disease (Calicivirus) in the US" (PDF). AgLearn. Retrieved 22 June 2019.
  52. ^ "Rabbit Hemorrhagic Disease_ Indiana". www.aphis.usda.gov. Animal and Plant Health Inspection Service. Retrieved 22 June 2019.
  53. ^ "Rabbit haemorrhagic disease, United States of America (Jefferson County, Pennsylvania report)". OiE. World Organization for Animal Health. Retrieved 22 June 2019.
  54. ^ "Rabbit hemorrhagic disease in British Columbia, Canada" (PDF). USDA. Retrieved 24 April 2020.
  55. ^ "First report of Rabbit Hemorrhagic Disease Type 2 In US found in Ohio". Ohio Department of Agriculture. Retrieved 22 June 2019.
  56. ^ McGann, C (19 June 2019). "Deadly rabbit disease confirmed on Orcas Island" (Press release). Olympia, WA: Washington State Department of Agriculture. Retrieved 6 December 2019.
  57. ^ "Highly Contagious and Deadly Rabbit Disease Found in California for First Time". NBC Los Angeles. May 14, 2020. Retrieved 2020-05-16.
  58. ^ a b c "Rabbit haemorrhagic disease, United States of America". OIE. Retrieved 8 May 2020.
  59. ^ Staff, H. N. N. (22 June 2022). "State: Virus that's deadly to rabbits detected on Maui". hawaiinewsnow.com. Retrieved 2022-06-23.
  60. ^ Gregg, DA; House, C; Berninger, M (1991). "Viral haemorrhagic disease of rabbits in Mexico : epidemiology and viral characterization". Revue Scientifique et Technique de l'OIE. 10 (2): 435–451. doi:10.20506/rst.10.2.556. ISSN 0253-1933. PMID 1760584.
  61. ^ "Acuerdo por el que se declara el territorio de los Estados Unidos Mexicanos, libre de la enfermedad hemorrágica viral de los conejos". Diario Oficial de la Federación. Retrieved 8 May 2020.
  62. ^ "Rabbit haemorrhagic disease, Mexico". OIE. Retrieved 8 May 2020.
  63. ^ "WAHIS". wahis.woah.org. Retrieved 2024-02-27.
  64. ^ Vargas, Bianca. "Detectan primer caso de fiebre hemorrágica viral". El Sol de Hidalgo | Noticias Locales, Policiacas, sobre México, Hidalgo y el Mundo (in Spanish). Retrieved 2024-02-27.
  65. ^ Ortiz, Yulissa. "Advierten sobre la enfermedad hemorrágica viral del conejo en Tulancingo". El Sol de Tulancingo | Noticias Locales, Policiacas, sobre México, Hidalgo y el Mundo (in Spanish). Retrieved 2024-02-27.
  66. ^ Vargas, Gustavo. "Inmunizan a más de 390 mil conejos en Tepeapulco". El Sol de Hidalgo | Noticias Locales, Policiacas, sobre México, Hidalgo y el Mundo (in Spanish). Retrieved 2024-02-27.
  67. ^ "Story Map Journal". dj.senasica.gob.mx. Retrieved 2024-02-27.
  68. ^ Farnós, O; Fernández, E; Chiong, M; et al. (2009). "Virus-like particles of the Rabbit Hemorrhagic Disease Virus obtained in yeast are able to induce protective immunity against classical strains and a viral subtype circulating in Cuba". Biotecnología Aplicada. 26 (3).

Read other articles:

Boxing at the African Games

Boxing competitions Boxing at the African GamesBoxingFirst event1965 BrazzavilleOccur everyfour yearsLast event2011 MaputoNext event2015 RabatBest Algeria (ALG) Boxing was an African Games event at its inaugural edition in 1965 and has continued to feature prominently at the competition in each of its subsequent editions. Editions Games Year Host city Best nation I 1965 Brazzaville  Egypt II 1973 Lagos  Nigeria III 1978 Algiers  Kenya IV 1987 Nairobi  Kenya V 199...

 

Distrik di Myanmar

Distrik (Burma: ခရိုင်, Kharuingcode: my is deprecated ; IPA: [kʰəjàiɰ̃]) adalah pembagian administratif tingkat dua di Myanmar. Distrik merupakan subdivisi dari negara bagian dan region di Myanmar. Berdasarkan pada Myanmar Information Management Unit (MIMU), pada Desember 2015, terdapat 76 distrik di Myanmar, yang di dalamnya terdapat subdivisi berupa kota praja, kota kecil, ward dan desa. Distrik di Myanmar (pada April 2022) Berikut ini adalah daftar distrik di Myanmar...

 

Huis ten Bosch

Istana Huis ten Bosch pada tahun 2012 Huis ten Bosch (pelafalan dalam bahasa Belanda: [ˈɦœy̆s tɛn bɔs]; Indonesia: Rumah di Hutan) adalah istana kerajaan di Den Haag, Belanda. Istana ini adalah salah satu dari tiga istana resmi Keluarga kerajaan Belanda, dua lainnya adalah Istana Noordeinde di Den Haag dan Royal Palace di Amsterdam. Huis ten Bosch adalah bekas rumah Ratu Beatrix dari Belanda sejak 1981. Raja Willem-Alexander dan keluarganya berencana untuk pindah ke istana ini. ...

العلاقات النيجيرية الهايتية

العلاقات النيجيرية الهايتية نيجيريا هايتي   نيجيريا   هايتي تعديل مصدري - تعديل   العلاقات النيجيرية الهايتية هي العلاقات الثنائية التي تجمع بين نيجيريا وهايتي.[1][2][3][4][5] مقارنة بين البلدين هذه مقارنة عامة ومرجعية للدولتين: وجه المقارنة ن�...

 

Aston Villa Football Club

Aston Villa Football ClubCalcio Villans, Lions, Claret & Blue Army (l'armata amarantoceleste) Segni distintiviUniformi di gara Casa Trasferta Terza divisa Colori sociali Bordeaux, celeste SimboliLeone Dati societariCittàBirmingham (Aston) Nazione Inghilterra ConfederazioneUEFA Federazione FA CampionatoPremier League Fondazione1874 Proprietario Wes Edens Presidente Nassef Sawiris Allenatore Unai Emery StadioVilla Park(42 785 posti) Sito webwww.avfc.co.uk Palmarès Titoli d'Inghi...

 

Miss Monde 1952

Élection deMiss Monde 1952 Élection Date 14 novembre 1952 Édition 2e Lieu Lyceum Theatre de Londres, Royaume-Uni Candidates Nombre 11 Débuts Miss Allemagne, Miss Finlande, Miss Irlande, Miss Suisse Disparitions Miss Belgique Gagnante Nom May Louise Flodin Âge 18 ans Région Suède Diffusion Chaîne Aucune Présentation Eric Morley Miss Monde 1951 Miss Monde 1953 modifier  Miss Monde 1952, est la 2e élection de Miss Monde, qui s'est déroulée au Lyceum Theatre, à Londre...

Tai Daeng language

Tai language of Vietnam and Laos Tai DaengRed TaiTáy-Môc-ChâuꪼꪕꪵꪒꪉTay lɛɛŋTai Daeng written in Tai Viet scriptRegionNorthwestern VietnamNortheastern LaosEthnicityTai DaengNative speakers(105,000 cited 1999–2007)[1]Language familyKra–Dai TaiSouthwestern (Thai)Chiang SaenTai DaengWriting systemTai VietLanguage codesISO 639-3tyrGlottologtaid1249ELPTai DaengDistribution of the Southwestern Tai languages. Tai Daeng, Táy-Môc-Châu or Red Tai is the language of the Tai ...

 

Monsieur Lazhar

Monsieur Lazharuna scena del filmTitolo originaleMonsieur Lazhar Lingua originalefrancese Paese di produzioneCanada Anno2011 Durata94 min Rapporto2,35:1 Generedrammatico RegiaPhilippe Falardeau SoggettoÉvelyne de la Chenelière (piéce teatrale Bashir Lazhar) SceneggiaturaPhilippe Falardeau ProduttoreLuc Déry, Kim McCraw Casa di produzioneMicroscope Productions, Les Films Seville Pictures Distribuzione in italianoOfficine UBU MontaggioStéphane Lafleur MusicheMartin Léon Interpreti e perso...

 

Iraq War and the war on terror

Iraq-US relations Further information: Saddam–al-Qaeda conspiracy theory, Timeline of Saddam–al-Qaeda conspiracy allegations, and Criticism of the war on terror On 19 March 2003, President George W. Bush addressed the nation from the Oval Office, announcing the beginning of Operation Iraqi Freedom. The people of the United States and our friends and allies will not live at the mercy of an outlaw regime that threatens the peace with weapons of mass murder. The Senate committee found that m...

Hiperpiron

Hiperpiron Kaisar Manouel I Komnenos Hiperpiron (Mata uang Bizantium), adalah uang yang digunakan di Kekaisaran Romawi Timur setelah jatuhnya Kekaisaran Romawi Barat, terdiri dari dua jenis koin: 'emas' koin solidus dan berbagai koin perunggu yang jelas nilainya. Pada akhir kekaisaran mata uang itu dikeluarkan hanya dengan perak 'stavrata' dan koin tembaga kecil tanpa emas. Ikonografi Solidus dari Justinian II, pemerintahan kedua, setelah tahun 705 Koin-koin Bizantium awal melanjutkan konvens...

 

西遊記大結局之仙履奇緣

本條目存在以下問題，請協助改善本條目或在討論頁針對議題發表看法。 此條目需要編修，以確保文法、用詞、语气、格式、標點等使用恰当。 (2013年8月6日)請按照校對指引，幫助编辑這個條目。（幫助、討論） 此條目剧情、虛構用語或人物介紹过长过细，需清理无关故事主轴的细节、用語和角色介紹。 (2020年10月6日)劇情、用語和人物介紹都只是用於了解故事主軸，輔助�...

 

Awareness ribbon

For awareness ribbon userboxes, see Wikipedia:Userboxes/Ribbons. Symbols meant to show support or raise consciousness for a cause This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Awareness ribbon – news · newspapers · books · scholar · JSTOR (April 2018) (Learn how and when to remove this message) A person we...

ميلان باروش

ميلان باروش (بالتشيكية: Milan Baroš)‏ معلومات شخصية الاسم الكامل ميلان باروش[1] الميلاد 28 أكتوبر 1981 (العمر 42 سنة)[1]فالاشسكي ميزيريتشي، التشيك الطول 1.83 م (6 قدم 0 بوصة)[2] مركز اللعب المهاجم الجنسية جمهورية التشيك  معلومات النادي النادي الحالي غلاطا سراي الرق...

 

Islam in Paraguay

Religion in Paraguay This article relies largely or entirely on a single source. Relevant discussion may be found on the talk page. Please help improve this article by introducing citations to additional sources.Find sources: Islam in Paraguay – news · newspapers · books · scholar · JSTOR (June 2022) Islam by countryWorld percentage of Muslims by country Africa Algeria Angola Benin Botswana Burkina Faso Burundi Cameroon Cape Verde Central African Repub...

 

كلية التمريض (جامعة البصرة)

  لمعانٍ أخرى، طالع كلية التمريض (توضيح). كلية التمريض معلومات التأسيس 2009 النوع كلية حكومية الموقع الجغرافي المكان بالحرم الجامعي البلد العراق  الإدارة العميد عبدالامير عبدالله يعقوب الموسوي إحصاءات متفرقات الموقع http://nur.uobasrah.edu.iq/ تعديل مصدري - تعديل   هذه المقال�...

Polish opera

The Haunted Manor by Stanisław Moniuszko performed at the Grand Theatre in Warsaw on September 22, 1966 Polish opera may be broadly understood to include operas staged in Poland and works written for foreign stages by Polish composers, as well as opera in the Polish language. The tradition reaches back to Italian language entertainments of the baroque. Romantic opera in Polish flourished alongside nationalism after the partition and is exemplified by the work of Stanisław Moniuszko. In the...

 

Sydney Shields

Artikel ini perlu diwikifikasi agar memenuhi standar kualitas Wikipedia. Anda dapat memberikan bantuan berupa penambahan pranala dalam, atau dengan merapikan tata letak dari artikel ini. Untuk keterangan lebih lanjut, klik [tampil] di bagian kanan. Mengganti markah HTML dengan markah wiki bila dimungkinkan. Tambahkan pranala wiki. Bila dirasa perlu, buatlah pautan ke artikel wiki lainnya dengan cara menambahkan [[ dan ]] pada kata yang bersangkutan (lihat WP:LINK untuk keterangan lebih lanjut...

 

1948 in the United States

List of events ← 1947 1946 1945 1948 in the United States → 1949 1950 1951 Decades: 1920s 1930s 1940s 1950s 1960s See also: History of the United States (1945–1964) Timeline of United States history (1930–1949) List of years in the United States 1948 in the United States1948 in U.S. states and territories States Alabama Arizona Arkansas California Colorado Connecticut Delaware Florida Georgia Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Mi...

Swan Island (Oregon)

Island on the Willamette River in Portland, Oregon, U.S. Swan IslandSwan Island from the west in 2018Swan IslandShow map of OregonSwan IslandShow map of Portland, OregonGeographyLocationWillamette RiverCoordinates45°33′38″N 122°42′32″W / 45.5606730°N 122.7089862°W / 45.5606730; -122.7089862 Swan Island is located on the Willamette River about 4.5 miles (7.2 km) downriver from downtown Portland, Oregon, United States. Although presently connected to the...

 

Rink hockey en France

Rink hockey en France Données-clés Fédération Fédération française de roller sports Clubs 80 (2012)[1] Licenciés 5 697 (2017)[2] Événements Championnat de France féminin et masculin modifier Le rink hockey est un sport confidentiel en France. La majorité des clubs est localisée sur la façade Atlantique et plus particulièrement en Bretagne et en Pays de la Loire. L'organisation des premières compétitions remonte au début du XXe siècle. Ce sport est surtout dévelo...