Pyrrolobenzodiazepine

Anthramycin contains pyrrolobenzodiazepine core

Pyrrolobenzodiazepines, (PBD) are a class of compound that may have antibiotic or anti-tumor properties.[1]

Some dimeric pyrrolobenzodiazepines are used as the cytotoxic drug payloads in antibody-drug conjugates, for example in loncastuximab tesirine.

History

Anthramycin, the first PBD monomer, was first synthesized in the 1960s.[2]

References

  1. ^ Hartley JA (June 2011). "The development of pyrrolobenzodiazepines as antitumour agents". Expert Opinion on Investigational Drugs. 20 (6): 733–44. doi:10.1517/13543784.2011.573477. PMID 21457108. S2CID 26275418.
  2. ^ Mantaj, Julia; Jackson, Paul J. M.; Rahman, Khondaker M.; Thurston, David E. (2017). "From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody–Drug Conjugates (ADCs)". Angewandte Chemie International Edition. 56 (2): 462–488. doi:10.1002/anie.201510610. PMC 5215561. PMID 27862776.
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