Cecilie was born on 5 September 1917 at Cecilienhof Palace in Potsdam, which had only been completed weeks prior to her birth, during World War I and the reign of paternal grandfather, Wilhelm II, as German Emperor and King of Prussia. One year after her birth, on 9 November 1918, her grandfather and other German monarchs abdicated and the German Empire was abolished.
After the war, Cecilienhof was confiscated by the state and the family moved to Oels in Lower Silesia, which was their private property. Cecilienhof was returned to Cecilie's family in 1926. In 1934, she was confirmed alongside her elder sister, Alexandrine, who had Down syndrome. She was educated at a women's seminary in Heiligengrabe and later worked at the Prussian Privy State Archives. During World War II, Cecilie worked at a pharmacy in Potsdam and trained as a nurse with the German Red Cross.
Cecilie and Harris were married on 21 June 1949 at Hohenzollern Castle.[3][2] The couple settled in Amarillo, Texas, where Harris worked as an interior designer. They had one daughter, Kira Alexandrine Brigid Cecilie Ingrid Harris (born 20 October 1954). Harris died of a cerebral hemorrhage in 1958, aged 39.[4]
While visiting family in Germany, Cecilie died in Königstein im Taunus on 21 April 1975, aged 57. She is buried at Hohenzollern Castle.