The first international game of that Persepolis played was on 26 July 1968 in Tehran, against the South Korean Army team.
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Persepolis was the first Iranian team to participate in the Asian Champion League. Persepolis earned three victories against Shahrbanai, Oghab and Pas, and a draw with Taj, to qualify for the 1969 Asian Cup. Persepolis was eliminated after two wins, a draw and a defeat in the group stage, and failed to reach the next two rounds.
AFC did not hold any club competitions on the continent from 1971 to 1985 due to political and security problems, and the opposition of the Arab countries with the presence of Israel in the competition.
Persepolis' second appearance in the Asian Cup came after winning the Hazfi Cup; Persepolis was eliminated by Mohammed Bangladesh, whose coach was Nasser Hejazi.
Following the introduction of the Asian Cup Winners' Cup, Persepolis qualified for the tournament on three occasions. In their first appearance in the competition, they won the title, and finished as runners-up on the second occasion.
In the 1990s (before the solar decade of the 1370s), and the early years of the new millennium, Persepolis participated in four editions of the AFC Champions League, reaching the semi-finals on each occasion. They subsequently reached the competition's final in 2018 and 2020, losing on both occasions.