Perfluorooctanesulfonic acid

Perfluorooctanesulfonic acid
PFOS molecule
Names
Preferred IUPAC name
1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluorooctane-1-sulfonic acid
Other names
PFOS
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.015.618 Edit this at Wikidata
EC Number
  • 217-179-8
KEGG
UNII
  • InChI=1S/C8HF17O3S/c9-1(10,3(13,14)5(17,18)7(21,22)23)2(11,12)4(15,16)6(19,20)8(24,25)29(26,27)28/h(H,26,27,28) checkY
    Key: YFSUTJLHUFNCNZ-UHFFFAOYSA-N checkY
  • InChI=1/C8HF17O3S/c9-1(10,3(13,14)5(17,18)7(21,22)23)2(11,12)4(15,16)6(19,20)8(24,25)29(26,27)28/h(H,26,27,28)
    Key: YFSUTJLHUFNCNZ-UHFFFAOYAS
  • FC(F)(C(F)(F)S(=O)(=O)O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
Properties
C8HF17O3S
Molar mass 500.13 g/mol
Boiling point 133 °C (271 °F; 406 K) at 6 torr
Acidity (pKa) <<0[1][2]
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Toxic, persistent environmental pollutant
GHS labelling:
GHS06: ToxicGHS08: Health hazardGHS09: Environmental hazard
Danger
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 3: Short exposure could cause serious temporary or residual injury. E.g. chlorine gasFlammability 0: Will not burn. E.g. waterInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
3
0
0
Pharmacology
Legal status
Related compounds
Related compounds
 Perfluorooctanoic acid (PFOA), Perfluorobutanesulfonic acid (PFBS), Perfluorooctanesulfonamide (PFOSA), Perfluorononanoic acid (PFNA)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Perfluorooctanesulfonic acid (PFOS) (conjugate base perfluorooctanesulfonate) is a chemical compound having an eight-carbon fluorocarbon chain and a sulfonic acid functional group, and thus it is a perfluorosulfonic acid and a perfluoroalkyl substance (PFAS). It is an anthropogenic (man-made) fluorosurfactant, now regarded as a global pollutant. PFOS was the key ingredient in Scotchgard, a fabric protector made by 3M, and related stain repellents. The acronym "PFOS" refers to the parent sulfonic acid and to various salts of perfluorooctanesulfonate. These are all colorless or white, water-soluble solids. Although of low acute toxicity, PFOS has attracted much attention for its pervasiveness and environmental impact. It was added to Annex B of the Stockholm Convention on Persistent Organic Pollutants in May 2009.[4]

History

In 1949, 3M began producing PFOS-based compounds by electrochemical fluorination.[5] In 1968, organofluorine compounds were detected in the blood serum of consumers, and in 1976, perfluorooctanoic acid (PFOA) or a related compound such as PFOS were suggested as components.[6][7][8] In 1997, 3M detected PFOS in blood from global blood banks,[9] although the company's internal documents indicate knowledge of this decades earlier, dating from the 1970s.[10] In 1999, the U.S. Environmental Protection Agency began investigating perfluorinated compounds after receiving data on the global distribution and toxicity of PFOS, the key ingredient in Scotchgard.[11] For these reasons, and USEPA pressure,[12] the primary American producer of PFOS, 3M, announced, in May 2000, the phaseout of the production of PFOS, PFOA, and PFOS-related products.[13][10] Most other manufacturers (particularly, those in Europe) phased out the production of PFOS and perfluorooctanoic acid (PFOA) in 2000 and 2006, respectively. A shorter-chain PFOS (perfluorohexanesulfonic acid, PFHxS), was included in Annex A to the Stockholm Convention in 2022.[14]

Currently, most of PFOS and PFOS-related chemicals are produced in China.[15]

Chemistry

The main method used for the industrial scale production of PFOS is electrochemical fluorination (ECF).[16] ECF is an electrolysis method whereby the precursor of octanesulfonyl fluoride is electrolyzed in a solution of hydrogen fluoride to give perfluorooctanesulfonyl fluoride. This production method also results in shorter chain perfluoroalkyl substances being formed.[citation needed] PFOS predominates in the resultant mixture. A distinct isomer ratio has been observed in PFOS produced by ECF, in the order of 70% linear PFOS, 25% branched and 5% terminal; this is not a function of the production process but rather that the precursor also exhibits this isomer ratio. ECF was the means by which 3M produced PFOS up until May 2000 when the company announced a phaseout of fluorosurfactants.

Although 89 constitutional isomers of PFOS are possible,[17] environmental samples usually consist of a mixture of the linear isomer and 10 branched isomers.[18]

Telomerisation involves constructing the PFOS molecule using short chain (often 2-carbon) precursors and adding a sulfonate group as a final step. This production process results in 100% linear PFOS. This production method, whilst cleaner and resulting in a much purer product than ECF, is not known to have been widely used except for the production of reagent grade PFOS and analytical standards.[citation needed]

Indirect routes

Perfluorooctylsulfonyl compounds degrade to PFOS.[19] Examples include N-methyl perfluorooctane sulfonamidoethanol [de] (N-MeFOSE), a carpet stain repellent, and N-ethyl perfluorooctane sulfonamidoethanol [de] (N-EtFOSE), a paper treatment.[20] Also perfluorooctanesulfonamide is a precursor.[21] About 50 precursors were named in the 2004 proposed Canadian ban on PFOS.[22]

Degradation

PFOS virtually does not degrade under environmental conditions and is thus highly persistent. Waste water treatment plants are also unable to degrade PFOS.[23] On the other hand, precursors are transformed to PFOS in waste water treatment plants.[24]

Properties

The C8F17 subunit of PFOS is hydrophobic and lipophobic, like other fluorocarbons, while the sulfonic acid/sulfonate group adds polarity. PFOS is an exceptionally stable compound in industrial applications and in the environment because of the effect of aggregate carbon–fluorine bonds. PFOS is a fluorosurfactant that lowers the surface tension of water more than that of hydrocarbon surfactants.

Uses

Perfluorooctanesulfonic acid is usually used as the sodium or potassium salts.

  • PFOS was the key ingredient in Scotchgard, a fabric protector made by 3M, and numerous stain repellents.
  • PFOS, together with PFOA, has also been used to make aqueous film forming foam (AFFF), a component of fire-fighting foams, and alcohol-type concentrate foams.
  • PFOS compounds can also be found in some impregnation agents for textiles, paper, and leather; in wax, polishes, paints, varnishes, and cleaning products for general use; in metal surfaces, and carpets.
  • In the semiconductor industry, PFOS is used in multiple photolithographic chemicals including: photoacid generators (PAGs) and anti-reflective coatings (ARCs). It has been phased out in the European Union semiconductor industry due to health concerns.
  • PFOS is the key ingredient in Skydrol, a fire-resistant hydraulic fluid used in commercial aviation.

The most important emission sources of PFOS are metal plating and fire-fighting foams.[25] Because of concerns about PFOS, F-53B has been used as a replacement for mist suppression in metal plating.[26]

Levels in humans

Because of its chemical nature, PFOS will remain in the body for several years. It is estimated that it takes 4 years for half of this substance to be eliminated from the body.[27]

PFOS is detected in the blood serum of almost all people in the U.S., but concentrations have been decreasing over time. In contrast, PFOS blood levels appear to be rising in China[28] where PFOS production continues. A study of ca. 2000 teenagers from 9 European countries with most samples collected in years 2016-2018 found higher blood concentrations of several PFOS’s in those, who consumed more seafood, eggs or offal, as well as in those from North and West (versus the South and East) Europe. Within the same country, boys had a higher PFOS concentrations than girls. A typical PFOS blood concentration range in this study was 1,500-2,500 ppb. [29]

Much higher levels of blood PFOS (12,830 ppb) have been reported in people with occupational exposure [30]—or possibly 1,656 parts per billion[31]—in a consumer. Occupationally exposed individuals may have an average level of PFOS over 1000 parts per billion, and a small segment of individuals in the upper range of the general population may be over the 91.5 parts per billion level.[32]

PFOS exposure has been demonstrated as early as fetal development during pregnancy since PFOS can easily pass through the placenta.[33] It has been shown that fetal exposure to PFOS is quite prevalent and has been shown to be detected in greater than 99% of umbilical cord serum samples.[34]

PFOS has been detected in U.S. freshwater fish,[35][36] as well as in municipal wastewater[37] and drinking water samples,[38] worldwide, at concentrations ranging between few ng/L and some μg/L.

Levels in wildlife

A variety of wildlife species have had PFOS levels measured in egg, liver, kidney, serum, and plasma samples and some of the highest recorded values as of January 2006 are listed below.[39]

Species Geography Year Sample PFOS (ppb)
Bald eagle Midwestern United States 1990–93 plasma 2,200
Brandt's cormorant California, US 1997 liver 970
Guillemot Baltic Sea, Sweden 1997 egg 614
Carrion crow Tokyo Bay, Japan 2000 liver 464
Red-throated loon North Carolina, US 1998 liver 861
Polar bear Sanikiluaq, Nunavut, Canada 2002 liver 3,100
Harbor seal Wadden Sea, the Netherlands 2002 muscle 2,725
Bottlenose dolphin Charleston, South Carolina, US 2003 plasma 1,315
Common dolphin Mediterranean Sea, Italy 1998 liver 940
Mink Michigan, US 2000–01 liver 59,500
Common shiner Ontario, Canada 2001 liver 72,900
Great tit near 3M, Port of Antwerp, Belgium 2007 liver 553–11,359[40]

Despite the global wide-ranging restriction, PFOS concentrations in air continued to increase at many monitoring stations between 2009 and 2017.[41]

Health effects in humans and wildlife

There is a growing body of research investigating the health effects of PFOS in humans and animals, including the reproductive, developmental, liver, kidney, thyroid, and immunological effects.[42] According to a 2002 report by the Environmental Directorate of the OECD, "PFOS is persistent, bioaccumulative, and toxic to mammalian species."[43]

Pregnancy outcomes

Several studies have focused on pregnancy outcomes in infants and mothers who are exposed to PFOS during pregnancy. For developing offspring, exposure to PFOS occurs through the placenta.[33] While the impact of PFOS compounds on fetal development continues to be an ongoing investigation, findings have demonstrated a relationship between PFOS exposure in pregnant mothers and negative birth outcomes.[44]

There has been some evidence to suggest that PFOS levels in pregnant women have been associated with preeclampsia, preterm labor, low birth weight and gestational diabetes.[45][46] Although, the strongest association is between PFOS levels with preterm birth and preeclampsia.[46][47] There has been some evidence to suggest that PFOS impairs fetal growth during pregnancy, although findings have been inconsistent.[46]

The specific physiological mechanisms behind adverse pregnancy outcomes with PFOS exposure remain unclear. One proposed cause has to do with PFOS impairment on placental blood flow.[42] This mechanism could help explain several of the pregnancy-related outcomes from PFOS exposure including such as intrauterine growth development, low birth weight, preterm birth labor, and preeclampsia. Additional physiological mechanisms may include disruption in inflammatory signals during pregnancy, decreased trophoblast signaling and trophoblast migration.[48] Additionally, PFOS exposure has been shown to be related to the downregulation genes corresponding to growth factors, pregnancy-related signal transducers, and maternal hormones.[49] PFOS impact on thyroid hormone regulation also has the potential to impact several birth outcomes.[50][51]

Breastfeeding and lactation

PFOS has been measured in breastmilk and is estimated to contribute the greatest level of PFOS exposure in infants. Specifically, the duration of breastfeeding has been shown to be associated with increases in PFOS in infants.[52] Some evidence has shown that breastmilk provides more than 94% of the PFOS exposure in infants up to six months old.[53] The Agency for Toxic Substances and Disease Registry (ATSDR) concluded that breastfeeding benefits continue to outweigh potential risks associated with PFOS in breastmilk.[54]

Thyroid disease

Increased levels of PFOS have been shown to accumulate in thyroid gland cells and have been associated with altered thyroid hormone levels in adults.[55][56] Appropriate levels of thyroid hormone during pregnancy are critical for a developing fetus as this hormone is involved with brain development and body growth.[57] Studies have demonstrated a relationship between PFOS exposure and thyroid dysfunction during pregnancy resulting in altered thyroid hormone levels in both the mother and the fetus.[58][59]

Hypercholesterolemia

PFOS has been associated with increased risk of abnormal levels of cholesterol.[60][61][62] Specifically, epidemiological studies in humans have reported an association between increased PFOS levels and the total cholesterol and low density lipoprotein (LDL) cholesterol.[63]

Chronic kidney disease

Serum levels of PFOS were found to be associated with increased risk of chronic kidney disease in the general US population.[64] "This association was independent of confounders such as age, sex, race/ethnicity, body mass index, diabetes, hypertension, and serum cholesterol level."[64]

Cancer

Research demonstrating the association between PFOS and cancer is still ongoing. A few studies have demonstrated an elevated risk for prostate and bladder cancer, however, there were notable limitations in the design and analysis of these studies.[46] As of November 2023, the International Agency for Research on Cancer (IARC) has classified PFOS as possibly carcinogenic to humans (Group 2b) based on “strong” mechanistic evidence.[65] The Division of Cancer Epidemiology & Genetics (DCEG) is currently investigating the association of several PFAS compounds and cancers including kidney cancer, testicular cancer, prostate cancer, ovarian and endometrial cancer, thyroid cancer, non-hodgkins lymphoma, and childhood leukemia.[66]

In wildlife

The levels observed in wild animals are considered sufficient to "alter health parameters".[67][68]

PFOS affects the immune system of male mice at a blood serum concentration of 91.5 parts per billion, raising the possibility that highly exposed people and wildlife are immunocompromised.[32] Chicken eggs dosed at 1 milligram per kilogram (or 1 part per million) of egg weight developed into juvenile chickens with an average of ~150 parts per billion in blood serum—and showed brain asymmetry and decreased immunoglobulin levels.[69]

Regulation

Globally

It was added to Annex B of the Stockholm Convention on Persistent Organic Pollutants in May 2009.[4] Originally, parties agreed on acceptable proposes (time-unlimited exemptions) for the following uses—in addition to a range of specific exemptions (time-limited):[70]

  • Photo-imaging
  • Photo-resist and anti-reflective coatings for semi-conductors
  • Etching agent for compound semi-conductors and ceramic filters
  • Aviation hydraulic fluids
  • Metal plating (hard metal plating) only in closed-loop systems
  • Certain medical devices (such as ethylene tetrafluoroethylene copolymer (ETFE) layers and radio-opaque ETFE production, in-vitro diagnostic medical devices, and CCD colour filters)
  • Fire-fighting foam
  • Insect baits for control of leaf-cutting ants from Atta spp. and Acromyrmex spp.

In 2019, it was decided to only keep one acceptable purpose:[71]

  • Insect baits with sulfluramid (CAS No. 4151-50-2) as an active ingredient for control of leaf-cutting ants from Atta spp. and Acromyrmex spp. for agricultural use only

Canada

In 2023, the Government of Canada is considering addressing PFAS as a class rather than as individual substances or in smaller groups. A report to conclude that PFAS as a class are harmful to human health and the environment, and to define risk management aspects and alternatives to PFAs, is under development."Per-and polyfluoroalkyl substances (PFAS)"

Europe

Based on an OECD study on PFOS[43] and a risk assessment by Europe's Scientific Committee on Health and Environmental Risks[72] the European Union practically banned the use of PFOS in finished and semi-finished products in 2006 (maximum content of PFOS: 0.005% by weight).[73] However, PFOS use for industrial applications (e.g. photolithography, mist suppressants for hard chromium plating, hydraulic fluids for aviation) was exempted. In 2009 this directive was incorporated into the REACH regulation.[74] In the summer of 2010 PFOS was added to the regulation on persistent organic pollutants and the threshold was lowered to max. 0.001% by weight (10 mg/kg).[75]

United States

In 2018 the State of Michigan established a legally enforceable groundwater cleanup level of 70 ppt for both PFOA and PFOS.[76]

In 2020 the Michigan Department of Environment, Great Lakes, and Energy (EGLE) adopted stricter drinking water standards in the form of maximum contaminant levels (MCLs), lowering acceptable levels from the 2018 enforceable groundwater cleanup levels of 70 ppt to 8 ppt for PFOA and 16 ppt for PFOS and adding MCLs for 5 previously unregulated PFAS compounds PFNA, PFHxA, PFHxS, PFBS, and HFPO-DA.[77][78]

In 2020, a California bill was passed banning PFOS and the following salts as an intentionally added ingredient from cosmetics: ammonium perfluorooctane sulfonate, diethanolamine perfluorooctane sulfonate, lithium perfluorooctane sulfonate and potassium perfluorooctane sulfonate.[79]

In March 2021 the U.S. EPA announced that it will develop national drinking water standards for PFOA and PFOS.[80]

In October 2021 the EPA proposed to designate PFOA and PFOS as hazardous substances in its PFAS Strategic Roadmap.[81][82] In September 2022 the EPA proposed to designate as hazardous substances under the Superfund Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA).

See also

References

  1. ^ Cheng J, Psillakis E, Hoffmann MR, Colussi AJ (July 2009). "Acid dissociation versus molecular association of perfluoroalkyl oxoacids: Environmental implications" (PDF). J. Phys. Chem. A. 113 (29): 8152–8156. Bibcode:2009JPCA..113.8152C. doi:10.1021/jp9051352. PMID 19569653.
  2. ^ Rayne S, Forest K, Friesen KJ (2009). "Extending the semi-empirical PM6 method for carbon oxyacid pKa prediction to sulfonic acids: Application towards congener-specific estimates for the environmentally and toxicologically relevant C1 through C8 perfluoroalkyl derivatives". Nature Precedings: 1. doi:10.1038/npre.2009.3011. hdl:10101/npre.2009.2922.1.
  3. ^ An Act To Stop Perfluoroalkyl and Polyfluoroalkyl Substances Pollution. 130th Maine Legislature, April 15, 2021
  4. ^ a b Governments unite to step-up reduction on global DDT reliance and add nine new chemicals under international treaty. Geneva: Stockholm Convention Secretariat. 8 May 2009.
  5. ^ Paul AG, Jones KC, Sweetman AJ (January 2009). "A first global production, emission, and environmental inventory for perfluorooctane sulfonate". Environ. Sci. Technol. 43 (2): 386–92. Bibcode:2009EnST...43..386P. doi:10.1021/es802216n. PMID 19238969.
  6. ^ Kennedy GL, Butenhoff JL, Olsen GW, et al. (2004). "The toxicology of perfluorooctanoate". Crit. Rev. Toxicol. 34 (4): 351–84. doi:10.1080/10408440490464705. PMID 15328768. S2CID 8873920.
  7. ^ Giesy JP, Kannan K (April 2002). "Perfluorochemical surfactants in the environment". Environ. Sci. Technol. 36 (7): 146A–152A. Bibcode:2002EnST...36..146G. doi:10.1021/es022253t. PMID 11999053.
  8. ^ Lau C, Butenhoff JL, Rogers JM (July 2004). "The developmental toxicity of perfluoroalkyl acids and their derivatives". Toxicol. Appl. Pharmacol. 198 (2): 231–41. Bibcode:2004ToxAP.198..231L. doi:10.1016/j.taap.2003.11.031. PMID 15236955.
  9. ^ "The Inside Story: 3M and Scotchgard". Environmental Working Group. Archived from the original on 25 April 2009. Retrieved 29 May 2009.
  10. ^ a b Fellner, Carrie (16 June 2018). "Toxic Secrets: Professor 'bragged about burying bad science' on 3M chemicals". Sydney Morning Herald. Retrieved 25 June 2018.
  11. ^ Ullah, Aziz (October 2006). "The Fluorochemical Dilemma: What the PFOS/PFOA fuss is all about" (PDF). Cleaning & Restoration. Archived from the original (PDF) on March 5, 2009.
  12. ^ Lee, Jennifer 8. (15 April 2003). "E.P.A. Orders Companies to Examine Effects of Chemicals". The New York Times. Retrieved 15 May 2009.{{cite news}}: CS1 maint: numeric names: authors list (link)
  13. ^ 3M: "PFOS-PFOA Information: What is 3M Doing?" Archived 2008-09-22 at the Wayback Machine Accessed October 25, 2008.
  14. ^ Richterová, D.; Govarts, E.; Fábelová, L.; Rausová, K.; Rodriguez Martin, L.; Gilles, L.; Remy, S.; Colles, A.; Rambaud, L.; Riou, M.; Gabriel, C.; Sarigiannis, D.; Pedraza-Diaz, S.; Ramos, J.J.; Kosjek, T. (2023). "PFAS levels and determinants of variability in exposure in European teenagers – Results from the HBM4EU aligned studies (2014–2021)". International Journal of Hygiene and Environmental Health. 247: 114057. Bibcode:2023IJHEH.24714057R. doi:10.1016/j.ijheh.2022.114057. PMC 9758614. PMID 36327670.
  15. ^ Wang, Tieyu; Wang, Pei; Meng, Jing; Liu, Shijie; Lu, Yonglong; Khim, Jong Seong; Giesy, John P. (2015). "A review of sources, multimedia distribution and health risks of perfluoroalkyl acids (PFAAs) in China". Chemosphere. 129: 87–99. Bibcode:2015Chmsp.129...87W. doi:10.1016/j.chemosphere.2014.09.021. PMID 25262946.
  16. ^ Risk profile on perfluorooctane sulfonate (PDF). POPs Review Committee. 2006.
  17. ^ Rayne, Sierra; Forest, Kaya; Friesen, Ken J. (2008). "Congener-specific numbering systems for the environmentally relevant C4 through C8 perfluorinated homologue groups of alkyl sulfonates, carboxylates, telomer alcohols, olefins, and acids, and their derivatives". Journal of Environmental Science and Health, Part A. 43 (12): 1391–1401. doi:10.1080/10934520802232030.
  18. ^ Buck, Robert C; Franklin, James; Berger, Urs; Conder, Jason M; Cousins, Ian T; de Voogt, Pim; Jensen, Allan Astrup; Kannan, Kurunthachalam; Mabury, Scott A; van Leeuwen, Stefan PJ (2011). "Perfluoroalkyl and Polyfluoroalkyl Substances in the Environment: Terminology, Classification, and Origins". Integrated Environmental Assessment and Management. 7 (4): 513–541. Bibcode:2011IEAM....7..513B. doi:10.1002/ieam.258. PMC 3214619. PMID 21793199.
  19. ^ "Annex 1: Perfluorooctane sulfonate (PFOS) and related compounds". Lists of PFOS, PFAS, PFCA, related compounds and chemicals that may degrade to PFCA. OECD. August 2007.
  20. ^ Renner R (March 2004). "Perfluorinated sources outside and inside". Environ. Sci. Technol. 38 (5): 80A. Bibcode:2004EnST...38...80R. doi:10.1021/es040387w. PMID 15046317.
  21. ^ Lehmler, HJ (March 2005). "Synthesis of environmentally relevant fluorinated surfactants—a review". Chemosphere. 58 (11): 1471–96. Bibcode:2005Chmsp..58.1471L. doi:10.1016/j.chemosphere.2004.11.078. PMID 15694468.
  22. ^ Pelley J (December 2004). "Canada moves to eliminate PFOS stain repellents". Environ. Sci. Technol. 38 (23): 452A. doi:10.1021/es040676k. PMID 15597866.
  23. ^ Trojanowicz, Marek; Bojanowska-Czajka, Anna; Bartosiewicz, Iwona; Kulisa, Krzysztof (2018). "Advanced Oxidation/Reduction Processes treatment for aqueous perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) – A review of recent advances". Chemical Engineering Journal. 336: 170–199. Bibcode:2018ChEnJ.336..170T. doi:10.1016/j.cej.2017.10.153.
  24. ^ Eriksson, Ulrika; Haglund, Peter; Kärrman, Anna (2017). "Contribution of precursor compounds to the release of per- and polyfluoroalkyl substances (PFASs) from waste water treatment plants (WWTPs)". Journal of Environmental Sciences (China). 61: 80–90. Bibcode:2017JEnvS..61...80E. doi:10.1016/j.jes.2017.05.004. PMID 29191318.
  25. ^ "Substance flow analysis for Switzerland". Federal Office for the Environment. 2009.
  26. ^ Yang, Renjun; Liu, Shuyu; Liang, Xiaoxing; Yin, Nuoya; Ruan, Ting; Jiang, Linshu; Faiola, Francesco (June 2020). "F–53B and PFOS treatments skew human embryonic stem cell in vitro cardiac differentiation towards epicardial cells by partly disrupting the WNT signaling pathway". Environmental Pollution. 261: 114153. Bibcode:2020EPoll.26114153Y. doi:10.1016/j.envpol.2020.114153. PMID 32088431. S2CID 211260717. Retrieved 20 December 2022.
  27. ^ "ATSDR Public Health Statement Perfluoroalkyls" (PDF).
  28. ^ Renner, Rebecca (2008). "PFOS phaseout pays off". Environ. Sci. Technol. 42 (13): 4618. Bibcode:2008EnST...42.4618R. doi:10.1021/es0871614. PMID 18677976.
  29. ^ PFAS levels and determinants of variability in exposure in European teenagers – Results from the HBM4EU aligned studies (2014–2021). 2023. Int J Hyg Environ Health. 247/. D. Richterová, E. Govarts, L. Fábelová, K. Rausová, L. Rodriguez Martin, L. Gilles, et al. doi: 10.1016/j.ijheh.2022.114057.
  30. ^ Fromme H, Tittlemier SA, Völkel W, Wilhelm M, Twardella D (May 2009). "Perfluorinated compounds—exposure assessment for the general population in Western countries". Int. J. Hyg. Environ. Health. 212 (3): 239–70. Bibcode:2009IJHEH.212..239F. doi:10.1016/j.ijheh.2008.04.007. PMID 18565792.
  31. ^ Olsen, Geary W; Church, Timothy R; Miller, John P; Burris, Jean M; Hansen, Kristen J; Lundberg, James K; Armitage, John B; Herron, Ross M; Medhdizadehkashi, Zahra; Nobiletti, John B; O'Neill, E Mary; Mandel, Jeffrey H; Zobel, Larry R (December 2003). "Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors". Environmental Health Perspectives. 111 (16): 1892–1901. doi:10.1289/ehp.6316. PMC 1241763. PMID 14644663.
  32. ^ a b Betts KS (July 2008). "Not immune to PFOS effects?". Environ. Health Perspect. 116 (7): A290. doi:10.1289/ehp.116-a290a. PMC 2453185. PMID 18629339.
  33. ^ a b Sunderland, Elsie M.; Hu, Xindi C.; Dassuncao, Clifton; Tokranov, Andrea K.; Wagner, Charlotte C.; Allen, Joseph G. (March 2019). "A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects". Journal of Exposure Science & Environmental Epidemiology. 29 (2): 131–147. doi:10.1038/s41370-018-0094-1. ISSN 1559-064X. PMC 6380916. PMID 30470793.
  34. ^ Tarapore, Pheruza; Ouyang, Bin (2021-04-05). "Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility?". International Journal of Environmental Research and Public Health. 18 (7): 3794. doi:10.3390/ijerph18073794. ISSN 1661-7827. PMC 8038605. PMID 33916482.
  35. ^ LaMotte, Sandee (17 January 2023). "Locally caught fish are full of dangerous chemicals called PFAS, study finds". CNN. Archived from the original on 14 February 2023. Retrieved 15 February 2023.
  36. ^ Barbo, Nadia; Stoiber, Tasha; Naidenko, Olga V.; Andrews, David Q. (1 March 2023). "Locally caught freshwater fish across the United States are likely a significant source of exposure to PFOS and other perfluorinated compounds". Environmental Research. 220: 115165. Bibcode:2023ER....22015165B. doi:10.1016/j.envres.2022.115165. ISSN 0013-9351. PMID 36584847. S2CID 255248441.
  37. ^ Arvaniti, Olga S.; Stasinakis, Athanasios S. (15 August 2015). "Review on the occurrence, fate and removal of perfluorinated compounds during wastewater treatment". Science of the Total Environment. 524–525: 81–92. Bibcode:2015ScTEn.524...81A. doi:10.1016/j.scitotenv.2015.04.023. PMID 25889547.
  38. ^ US EPA, OW (September 1, 2015). "Third Unregulated Contaminant Monitoring Rule". US EPA.
  39. ^ Houde M, Martin JW, Letcher RJ, Solomon KR, Muir DC (June 2006). "Biological monitoring of polyfluoroalkyl substances: A review". Environ. Sci. Technol. 40 (11): 3463–73. Bibcode:2006EnST...40.3463H. doi:10.1021/es052580b. PMID 16786681. Supporting Information (PDF).
  40. ^ Dauwe, Tom; Van de Vijver, Kristin; De Coen, Wim; Eens, Marcel (April 2007). "PFOS levels in the blood and liver of a small insectivorous songbird near a fluorochemical plant". Environment International. 33 (3): 357–361. Bibcode:2007EnInt..33..357D. doi:10.1016/j.envint.2006.11.014. PMID 17188355.
  41. ^ Saini, Amandeep; Chinnadurai, Sita; Schuster, Jasmin K.; Eng, Anita; Harner, Tom (February 2023). "Per- and polyfluoroalkyl substances and volatile methyl siloxanes in global air: Spatial and temporal trends". Environmental Pollution. 323: 121291. Bibcode:2023EPoll.32321291S. doi:10.1016/j.envpol.2023.121291. PMID 36796663. S2CID 256881039.
  42. ^ a b Blake, Bevin E.; Fenton, Suzanne E. (October 2020). "Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects". Toxicology. 443: 152565. Bibcode:2020Toxgy.44352565B. doi:10.1016/j.tox.2020.152565. ISSN 1879-3185. PMC 7530144. PMID 32861749.
  43. ^ a b OECD (2002). "Hazard Assessment of Perfluorooctane Sulfonate (PFOS) and its Salts" (PDF). ENV/JM/RD(2002)17/FINAL (Page 5). Archived from the original (PDF) on September 16, 2015.
  44. ^ Gao, Xuping; Ni, Wanze; Zhu, Sui; Wu, Yanxin; Cui, Yunfeng; Ma, Junrong; Liu, Yanhua; Qiao, Jinlong; Ye, Yanbin; Yang, Pan; Liu, Chaoqun (October 2021). "Per- and polyfluoroalkyl substances exposure during pregnancy and adverse pregnancy and birth outcomes: A systematic review and meta-analysis". Environmental Research. 201: 111632. Bibcode:2021ER....20111632G. doi:10.1016/j.envres.2021.111632. ISSN 1096-0953. PMID 34237336.
  45. ^ Stein, C. R.; Savitz, D. A.; Dougan, M. (19 August 2009). "Serum Levels of Perfluorooctanoic Acid and Perfluorooctane Sulfonate and Pregnancy Outcome". American Journal of Epidemiology. 170 (7): 837–846. doi:10.1093/aje/kwp212. PMID 19692329.
  46. ^ a b c d "Health Effects Support Document for Perfluorooctane Sulfonate (PFOS)" (PDF).
  47. ^ Gao, Xuping; Ni, Wanze; Zhu, Sui; Wu, Yanxin; Cui, Yunfeng; Ma, Junrong; Liu, Yanhua; Qiao, Jinlong; Ye, Yanbin; Yang, Pan; Liu, Chaoqun (October 2021). "Per- and polyfluoroalkyl substances exposure during pregnancy and adverse pregnancy and birth outcomes: A systematic review and meta-analysis". Environmental Research. 201: 111632. Bibcode:2021ER....201k1632G. doi:10.1016/j.envres.2021.111632. ISSN 1096-0953. PMID 34237336.
  48. ^ Szilagyi, John T.; Freedman, Anastasia N.; Kepper, Stewart L.; Keshava, Arjun M.; Bangma, Jackie T.; Fry, Rebecca C. (2020-06-01). "Per- and Polyfluoroalkyl Substances Differentially Inhibit Placental Trophoblast Migration and Invasion In Vitro". Toxicological Sciences. 175 (2): 210–219. doi:10.1093/toxsci/kfaa043. ISSN 1096-0929. PMC 7253207. PMID 32219433.
  49. ^ Li, Xiaoheng; Ye, Leping; Ge, Yufei; Yuan, Kaiming; Zhang, Yufei; Liang, Yong; Wei, Jia; Zhao, Connie; Lian, Qing-Quan; Zhu, Xueqiong; Ge, Ren-Shan (March 2016). "In utero perfluorooctane sulfonate exposure causes low body weights of fetal rats: A mechanism study". Placenta. 39: 125–133. doi:10.1016/j.placenta.2016.01.010. ISSN 1532-3102. PMID 26992685.
  50. ^ Ames, Jennifer L.; Windham, Gayle C.; Lyall, Kristen; Pearl, Michelle; Kharrazi, Martin; Yoshida, Cathleen K.; Van de Water, Judy; Ashwood, Paul; Croen, Lisa A. (March 2020). "Neonatal Thyroid Stimulating Hormone and Subsequent Diagnosis of Autism Spectrum Disorders and Intellectual Disability". Autism Research. 13 (3): 444–455. doi:10.1002/aur.2247. ISSN 1939-3806. PMID 31823519. S2CID 209316725.
  51. ^ Moog, N.K.; Entringer, S.; Heim, C.; Wadhwa, P.D.; Kathmann, N.; Buss, C. (February 2017). "Influence of maternal thyroid hormones during gestation on fetal brain development". Neuroscience. 342: 68–100. doi:10.1016/j.neuroscience.2015.09.070. ISSN 0306-4522. PMC 4819012. PMID 26434624.
  52. ^ Mogensen, Ulla B.; Grandjean, Philippe; Nielsen, Flemming; Weihe, Pal; Budtz-Jørgensen, Esben (2015-09-01). "Breastfeeding as an Exposure Pathway for Perfluorinated Alkylates". Environmental Science & Technology. 49 (17): 10466–10473. Bibcode:2015EnST...4910466M. doi:10.1021/acs.est.5b02237. ISSN 1520-5851. PMC 6190571. PMID 26291735.
  53. ^ Haug, Line S.; Huber, Sandra; Becher, Georg; Thomsen, Cathrine (May 2011). "Characterisation of human exposure pathways to perfluorinated compounds--comparing exposure estimates with biomarkers of exposure". Environment International. 37 (4): 687–693. Bibcode:2011EnInt..37..687H. doi:10.1016/j.envint.2011.01.011. hdl:10852/12717. ISSN 1873-6750. PMID 21334069.
  54. ^ "PFAS and Breastfeeding | ATSDR". www.atsdr.cdc.gov. 2021-11-19. Retrieved 2022-04-07.
  55. ^ Coperchini, F.; Awwad, O.; Rotondi, M.; Santini, F.; Imbriani, M.; Chiovato, L. (February 2017). "Thyroid disruption by perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA)". Journal of Endocrinological Investigation. 40 (2): 105–121. doi:10.1007/s40618-016-0572-z. ISSN 1720-8386. PMID 27837466. S2CID 207503788.
  56. ^ Dallaire, Renée; Dewailly, Éric; Pereg, Daria; Dery, Serge; Ayotte, Pierre (September 2009). "Thyroid Function and Plasma Concentrations of Polyhalogenated Compounds in Inuit Adults". Environmental Health Perspectives. 117 (9): 1380–1386. doi:10.1289/ehp.0900633. PMC 2737013. PMID 19750101.
  57. ^ Shahid, Muhammad A.; Ashraf, Muhammad A.; Sharma, Sandeep (2022), "Physiology, Thyroid Hormone", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 29763182, retrieved 2022-03-31
  58. ^ Coperchini, Francesca; Croce, Laura; Ricci, Gianluca; Magri, Flavia; Rotondi, Mario; Imbriani, Marcello; Chiovato, Luca (2021). "Thyroid Disrupting Effects of Old and New Generation PFAS". Frontiers in Endocrinology. 11: 612320. doi:10.3389/fendo.2020.612320. ISSN 1664-2392. PMC 7851056. PMID 33542707.
  59. ^ Boesen, Sophie A. H.; Long, Manhai; Wielsøe, Maria; Mustieles, Vicente; Fernandez, Mariana F.; Bonefeld-Jørgensen, Eva C. (2020-10-13). "Exposure to Perflouroalkyl acids and foetal and maternal thyroid status: a review". Environmental Health. 19 (1): 107. Bibcode:2020EnvHe..19..107B. doi:10.1186/s12940-020-00647-1. ISSN 1476-069X. PMC 7557068. PMID 33050930.
  60. ^ Steenland, K.; Tinker, S.; Frisbee, S.; Ducatman, A.; Vaccarino, V. (21 October 2009). "Association of Perfluorooctanoic Acid and Perfluorooctane Sulfonate With Serum Lipids Among Adults Living Near a Chemical Plant". American Journal of Epidemiology. 170 (10): 1268–1278. doi:10.1093/aje/kwp279. PMID 19846564.
  61. ^ Nelson, Jessica W.; Hatch, Elizabeth E.; Webster, Thomas F. (February 2010). "Exposure to Polyfluoroalkyl Chemicals and Cholesterol, Body Weight, and Insulin Resistance in the General U.S. Population". Environmental Health Perspectives. 118 (2): 197–202. doi:10.1289/ehp.0901165. PMC 2831917. PMID 20123614.
  62. ^ US EPA, OW (2016-05-05). "Drinking Water Health Advisories for PFOA and PFOS". www.epa.gov. Retrieved 2022-03-31.
  63. ^ Saikat, Sohel; Kreis, Irene; Davies, Bethan; Bridgman, Stephen; Kamanyire, Robie (February 2013). "The impact of PFOS on health in the general population: a review". Environmental Science: Processes & Impacts. 15 (2): 329–335. doi:10.1039/c2em30698k. ISSN 2050-7895. PMID 25208696.
  64. ^ a b Shankar, Anoop; Jie Xiao; Alan Ducatman (2011-10-15). "Perfluoroalkyl Chemicals and Chronic Kidney Disease in US Adults". American Journal of Epidemiology. 174 (8): 893–900. doi:10.1093/aje/kwr171. PMC 3218627. PMID 21873601.
  65. ^ Zahm, Shelia; Bonde, Jens Peter; Chiu, Weihsueh A; Hoppin, Jane; Kanno, Jun; Abdallah, Mohamed; Blystone, Chad R; Calkins, Miriam M; Dong, Guang-Hui; Dorman, David C; Fry, Rebecca; Guo, Huan; Haug, Line S; Hofmann, Jonathan N; Iwasaki, Motoki (2023). "Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid". The Lancet Oncology. 25 (1): 16–17. doi:10.1016/S1470-2045(23)00622-8. PMID 38043561.
  66. ^ "PFAS Exposure and Risk of Cancer - National Cancer Institute". dceg.cancer.gov. 2020-10-15. Retrieved 2022-04-14.
  67. ^ Peden-Adams, M. M.; Keil, D. E.; Romano, T.; Mollenhauer, M. A. M.; Fort, D. J.; Guiney, P. D.; Houde, M.; Kannan, K.; Muir, D. C.; Rice, C. D.; Stuckey, J.; Segars, A. L.; Scott, T.; Talent, L.; Bossart, G. D.; Fair, P. A.; Keller, J. M. (2009). "Health effects of perfluorinated compounds—What are the wildlife telling us?". Reproductive Toxicology. 27 (3–4): 414–415. Bibcode:2009RepTx..27..414P. doi:10.1016/j.reprotox.2008.11.016.
  68. ^ Peden-Adams et al. (June 2008). In PFAA Days II Archived 2011-07-26 at the Wayback Machine (PDF). p. 28.
  69. ^ Peden-Adams, M.; Stuckey, J.; Gaworecki, K.; Berger-Ritchie, J.; Bryant, K.; Jodice, P.; Scott, T.; Ferrario, J.; Guan, B.; Vigo, C.; Boone, J. S.; McGuinn, W. D.; Dewitt, J. C.; Keil, D. E. (2009). "Developmental toxicity in white leghorn chickens following in ovo exposure to perfluorooctane sulfonate (PFOS)". Reproductive Toxicology (Elmsford, N.Y.). 27 (3–4): 307–318. Bibcode:2009RepTx..27..307P. doi:10.1016/j.reprotox.2008.10.009. PMID 19071210.
  70. ^ SC-4/17: Listing of perfluorooctane sulfonic acid, its salts and perfluorooctane sulfonyl fluoride
  71. ^ SC-9/4: Perfluorooctane sulfonic acid, its salts and perfluorooctane sulfonyl fluoride
  72. ^ SCHER (2005). "RPA's report "Perfluorooctane Sulphonates Risk reduction strategy and analysis of advantages and drawbacks"". Scientific Committee on Health and Environmental Risks, European Commission.
  73. ^ "DIRECTIVE 2006/122/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 12 December 2006".
  74. ^ "COMMISSION REGULATION (EC) No 552/2009 of 22 June 2009".
  75. ^ "COMMISSION REGULATION (EU) No 757/2010 of 24 August 2010".
  76. ^ "Michigan abruptly sets PFAS cleanup rules". mlive. 2018-01-10. Retrieved 2022-03-27.
  77. ^ Matheny, Keith (3 August 2020). "Michigan's drinking water standards for these chemicals now among toughest in nation". Detroit Free Press. Archived from the original on 31 January 2022. Retrieved 31 March 2022.
  78. ^ "New state drinking water standards pave way for expansion of Michigan's PFAS clean-up efforts". Michigan.gov. 3 August 2020. Archived from the original on 3 January 2022. Retrieved 6 April 2022.
  79. ^ "Assembly Bill No. 2762". State of California. September 30, 2020. Retrieved 10 October 2020.
  80. ^ EPA (2021-03-03). "Announcement of Final Regulatory Determinations for Contaminants on the Fourth Drinking Water Contaminant Candidate List." Federal Register, 86 FR 12272
  81. ^ RIN 2050-AH09
  82. ^ Docket EPA-HQ-OLEM-2019-0341

Read other articles:

Ketika hidup memberi Anda lemon, buatlah limun

Potongan lemon yang tampak cerah di antara dua lemon abu-abu dan dengan latar belakang abu-abu Ketika hidup memberi Anda lemon, buatlah limun adalah ungkapan pepatah yang digunakan untuk mendorong optimisme dan sikap positif yang bisa dilakukan dalam menghadapi kesulitan atau kesialan. Lemon menunjukkan asam atau kesulitan dalam hidup; membuat limun mengubah mereka menjadi sesuatu yang positif atau diinginkan. Asal mula Ungkapan ini awalnya diciptakan oleh penulis Kristen anarkis Elbert Hubba...

 

 

Stasiun Yunoki (Fuji)

CC01Stasiun Yunoki柚木駅Stasiun JR YunokiLokasiYunoki 213, Fuji-shi, Shizuoka-kenJepangKoordinat35°9′26″N 138°38′21″E / 35.15722°N 138.63917°E / 35.15722; 138.63917Koordinat: 35°9′26″N 138°38′21″E / 35.15722°N 138.63917°E / 35.15722; 138.63917Operator JR CentralJalur Jalur MinobuLetak2.8 kilometer dari FujiJumlah peron1 peron pulauInformasi lainStatusTanpa stafSejarahDibuka1 Oktober 1938Nama sebelumnyaMotoichiba (sampa...

 

 

Islam di Argentina

Islam menurut negara Afrika Aljazair Angola Benin Botswana Burkina Faso Burundi Kamerun Tanjung Verde Republik Afrika Tengah Chad Komoro Republik Demokratik Kongo Republik Kongo Djibouti Mesir Guinea Khatulistiwa Eritrea Eswatini Etiopia Gabon Gambia Ghana Guinea Guinea-Bissau Pantai Gading Kenya Lesotho Liberia Libya Madagaskar Malawi Mali Mauritania Mauritius Maroko Mozambik Namibia Niger Nigeria Rwanda Sao Tome dan Principe Senegal Seychelles Sierra Leone Somalia Somaliland Afrika Selatan ...

AO-35

AO-35 Jenis Senapan serbu Negara asal  Uni Soviet Spesifikasi Peluru 7,62 x 39 mm M43 Kaliber 7,62mm Mekanisme Gas Amunisi Magazen box isi 30 butir Alat bidik Bidikan besi AO-35 adalah senapan serbu asal Uni Soviet[1] yang mengadopsi model AK-47 dan menggunakan popor kayu berlapis untuk mengurangi berat senapan. Referensi ^ Small Arms Illustrated, 2010. Artikel bertopik senapan ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.lbs lbsAK-...

 

 

Greenvale, Victoria

Suburb of Melbourne, Victoria, AustraliaGreenvaleMelbourne, VictoriaWoodlands Historic Park in Greenvale serves as a native animal sanctuary, Wurundjeri heritage site, and public walking space, dotted with historical early settlement ruins.GreenvaleLocation in metropolitan MelbourneCoordinates37°37′59″S 144°52′59″E / 37.633°S 144.883°E / -37.633; 144.883Population21,274 (2021 census)[1] • Density3,175/km2 (8,220/sq mi)Establis...

 

 

Daftar Bupati Bengkulu Tengah

Bupati Bengkulu TengahLambang Kabupaten Bengkulu TengahPetahanaHeriyandi Roni (Pj)sejak 22 Mei 2022KediamanKantor Bupati Bengkulu Tengah, Karang TinggiMasa jabatan5 tahunDibentuk24 Juni 2008Pejabat pertamaBambang SusenoSitus webbengkulutengahkab.go.id Berikut adalah Daftar Bupati Kabupaten Bengkulu Tengah, Provinsi Bengkulu, Indonesia dari masa ke masa. No Portret Bupati Mulai menjabat Akhir menjabat Prd. Ket. Wakil Bupati — H. Bambang Suseno, SKM, M.M. 2008 2010 — [Ket. 1] �...

Réservoir conforme

Pour les articles homonymes, voir CFT. Mise en place de réservoirs conformes sur un F-15E. Ils s'adaptent en étant plaqués contre les entrées d'air. Un F-16I Sufa israélien, dérivé du F-16D Block 50/52+, équipé de deux CFT au-dessus sur les côtés du fuselage. Le prototype F-CK-1D (« Brave Hawk ») taïwanais, équipé de CFT, et le prototype monoplace F-CK-1C, lors de leur révélation au public, en mars 2007. Les réservoirs conformes (en anglais : Conformal Fuel ...

 

 

Jesus Camp

2006 American documentary film Jesus CampPromotional release posterDirected byHeidi EwingRachel GradyProduced byHeidi EwingRachel GradyStarringBecky FischerMike PapantonioCinematographyMira ChangJenna RosherEdited byEnat SidiMusic byForce TheoryDistributed byMagnolia PicturesA&E Indie FilmsRelease date September 15, 2006 (2006-09-15) Running time85 minutesCountryUnited StatesLanguageEnglishBox office$1 million Jesus Camp is a 2006 American documentary film directed by Rache...

 

 

Serge Gainsbourg

Pour les articles homonymes, voir Gainsbourg et Ginsburg. Cet article possède un paronyme, voir Gainsborough. Serge GainsbourgSerge Gainsbourg en 1981.BiographieNaissance 2 avril 19284e arrondissement de Paris (France)Décès 2 mars 1991 (à 62 ans)7e arrondissement de Paris (France)Sépulture Cimetière du MontparnasseNom de naissance Lucien GinsburgSurnoms Gainsbarre, Julien Gris, Julien Grix, L'homme à tête de chouNationalité françaiseFormation Lycée CondorcetÉcole normale de ...

Nanana.... It's A Beautiful Day

Artikel ini tidak memiliki referensi atau sumber tepercaya sehingga isinya tidak bisa dipastikan. Tolong bantu perbaiki artikel ini dengan menambahkan referensi yang layak. Tulisan tanpa sumber dapat dipertanyakan dan dihapus sewaktu-waktu.Cari sumber: Nanana.... It's A Beautiful Day – berita · surat kabar · buku · cendekiawan · JSTOR Nanana.... It's A Beautiful DayAlbum studio karya Mikki & MinniDirilis2012GenrePopLabelNagaswara Nananana.... I...

 

 

Apple Watch Ultra

Line of smartwatch Apple Watch UltraApple Watch Ultra 2DeveloperApple Inc.ManufacturerQuanta Computer[1]Compal Electronics[2](contract manufacturer)TypeSmartwatchRelease dateUltra: September 23, 2022; 18 months ago (2022-09-23)Ultra 2: September 22, 2023; 6 months ago (2023-09-22)Operating systemwatchOSWebsiteapple.com/watch Apple Watch Ultra is a line of sport smartwatches produced by Apple Inc. as part of the Apple Watch product line. Intr...

 

 

Philosophical Papers

Academic journalPhilosophical PapersDisciplinePhilosophyLanguageEnglishEdited byWard E. Jones, Uchenna OkejaPublication detailsHistory1986-present[1]PublisherRoutledge (South Africa)FrequencyTriannualStandard abbreviationsISO 4 (alt) · Bluebook (alt1 · alt2)NLM (alt) · MathSciNet (alt )ISO 4Philos. Pap.IndexingCODEN (alt · alt2) · JSTOR (alt) · LCCN (alt)MIAR · NLM (alt) &#...

Visa policy of Libya

Policy on permits required to enter Libya Politics of Libya Member State of the Arab League Constitution 2017 draft constitution 2011 Constitutional Declaration (Basic Law) 1977 People's Authority 1969 Constitution 1951 Constitution Executive Presidential Council (in Tripoli) Chairman: Mohamed al-Menfi Government of National Unity (in Tripoli) Prime Minister: Abdul Hamid Dbeibeh Government of National Stability (in Tobruk) Prime Minister: Osama Hammad (acting) Legislature High Council of Sta...

 

 

Eintracht Braunschweig

German association football club from Braunschweig, Lower Saxony Football clubEintracht BraunschweigFull nameBraunschweiger Turn- undSportverein Eintracht von 1895 e.V.Nickname(s)Die Löwen (The Lions)[citation needed]Founded15 December 1895; 128 years ago (1895-12-15)GroundEintracht-Stadion,BraunschweigCapacity23,325[contradictory][citation needed]PresidentNicole Kumpis[citation needed]Head coachDaniel ScherningLeague2. Bundesliga2022–232. ...

 

 

نظام أباد (إسلام شهر)

  لمعانٍ أخرى، طالع نظام أباد (توضيح). نظام أباد نظام اباد  - قرية -    تقسيم إداري البلد  إيران[1] المحافظة طهران المقاطعة مقاطعة اسلام شهر الناحية Central القسم الريفي قسم دة عباس الريفي (مقاطعة اسلام شهر) خصائص جغرافية إحداثيات 35°32′01″N 51°16′36″E / ࿯...

Falso Dimitri I di Russia

Questa voce o sezione sull'argomento nobili russi non cita le fonti necessarie o quelle presenti sono insufficienti. Puoi migliorare questa voce aggiungendo citazioni da fonti attendibili secondo le linee guida sull'uso delle fonti. (Falso) Demetrio I di RussiaЛжедмитрий IZar di tutte le Russie(usurpatore)Stemma In carica11 giugno[1] 1605 –27 maggio[2] 1606 Incoronazione30 luglio 1605 PredecessoreFëdor II SuccessoreBasilio IV Nome completoin ...

 

 

قائمة البعثات الدبلوماسية في النمسا

خريطة البعثات الدبلوماسية في النمسا تورد هذه الصفحة قائمة بالبعثات الدبلوماسية المقيمة في النمسا. في الوقت الحاضر، تستضيف مدينة فيينا العاصمة 123 سفارة. وهناك عدة بلدان أخرى لديها سفراء معتمدون لدى النمسا، ويقيم معظمهم في برلين. ولا تشمل هذه القائمة القنصليات الفخرية. سفار...

 

 

Tekken 2: Kazuya's Revenge

2014 American filmTekken 2: Kazuya's RevengeSingaporan theatrical release posterDirected byWych KaosWritten by Nicole Jones Steven Paul Based onTekkenby Bandai Namco GamesProduced by Steven Paul Pimol Srivikorn Starring Kane Kosugi Cary-Hiroyuki Tagawa Rade Šerbedžija Gary Daniels Kelly Wenham CinematographyWych KaosEdited by Vance Null Robert Ferretti Music byMisha SegalProductioncompanyCrystal Sky PicturesDistributed bySP DistributionRelease dates August 6, 2014 (2014-08-06...

Austrian literature

Overview of literature in Austria This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Austrian literature – news · newspapers · books · scholar · JSTOR (August 2021) (Learn how and when to remove this message) This article possibly contains original research. Please improve it by verifying the claims made and ad...

 

 

Музей американского искусства Уитни

Музей американского искусства Уитниангл. Whitney Museum of American Art Дата основания 1931[1][2] Дата открытия 1931 Основатель Гертруда Вандербильт[1] Местонахождение Манхэттен Адрес 99 Gansevoort Street, Lower Manhattan, New York City Посетителей в год 492 500 чел. (2021)[3] Директор Adam D. Weinberg[�...