Park started his career as an actor in television drama Sarang (1990). In the film Cambo (1985). In 1987, for his performance as a college student in Youth sketch of Mimi and Cheolsu, he won the best new actor award at the Baeksang Arts Awards.
In Chilsu and Mansu (1988), Park gave a brilliant performance in acting as Chil-soo, who leads his life in agony in the society of that time; it created a shock to Korean society.
Park went to the United States in 1992 to enroll in the graduate school of New York University, majoring in acting education. After getting his master's degree, he returned to Korea and appeared in Two Cops (1993), a box office hit, which brought him and Ahn Sung-ki the best actor award at the Grand Bell Awards.
In 2006, Park reunited with his Two Cops co-star Ahn Sung-ki in Radio Star, portraying a rock star. He won the best actor's award of Blue Dragon Film Awards with Ahn but missed Grand Bell Awards; only Ahn got the prize.
From April 11–17, 2007, the event "Park Joong-hoon Mini Retrospective" was held at Jacob Burns Film Center, presenting six films.[7] It was the first time for an Asian actor retrospective to be held there. During the event, Park had talk sessions with Jonathan Demme and Ahn Sung-ki.
Near the end of decade, Park came back into the limelight with Haeundae (2009), Korea's first disaster film that situates itself in a tsunami coming to the popular beach of Busan.
Park is opposed to reducing Screen quota, along with Ahn Sung-ki, Choi Min-sik and others; he became second actor (the first is Ahn, and the third is Choi) of relay demonstration by actors and film directors, on February 5, 2006.
^ ab"박중훈". Cinefox (씨네폭스) (in Korean). Archived from the original on 2023-12-13. Retrieved 2023-12-13.
^Heo Seol-hee (February 5, 2021). "박중훈, 나무엑터스 전속계약…유준상·지성 한솥밥". My Daily (in Korean). Archived from the original on December 8, 2021. Retrieved February 5, 2021.
^"다음 프로필". Daum (in Korean). Archived from the original on 2021-12-08. Retrieved 2018-08-10.