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Pacritinib
Clinical data
Trade names	Vonjo
Other names	SB1518
License data	US DailyMed: Pacritinib;
Routes of; administration	By mouth
ATC code	L01EJ03 (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name (16E)-11-[2-(1-Pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,26-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene;
CAS Number	937272-79-2;
PubChem CID	46216796;
DrugBank	DB11697;
ChemSpider	28518965;
UNII	G22N65IL3O;
KEGG	D11768;
ChEBI	= CHEBI:231350 =;
ChEMBL	ChEMBL2035187;
PDB ligand	6T3 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID801045679 ;
Chemical and physical data
Formula	C28H32N4O3
Molar mass	472.589 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1cc2cc(c1)-c3ccnc(n3)Nc4ccc(c(c4)COC/C=C/COC2)OCCN5CCCC5;
	InChI InChI=1S/C28H32N4O3/c1-2-13-32(12-1)14-17-35-27-9-8-25-19-24(27)21-34-16-4-3-15-33-20-22-6-5-7-23(18-22)26-10-11-29-28(30-25)31-26/h3-11,18-19H,1-2,12-17,20-21H2,(H,29,30,31)/b4-3+; Key:HWXVIOGONBBTBY-ONEGZZNKSA-N;

Pacritinib, sold under the brand name Vonjo, is an anti-cancer medication used to treat myelofibrosis.^[1]^[2] It is a macrocyclic protein kinase inhibitor. It mainly inhibits Janus kinase 2 (JAK2) and Fms-like tyrosine kinase 3\CD135 (FLT3).

Common side effects include diarrhea, low platelet counts, nausea, anemia, and swelling in legs.^[2]

Medical uses

Pacritinib in indicated to treat adults who have a rare form of a bone marrow disorder known as intermediate or high-risk primary or secondary myelofibrosis and who have platelet (blood clotting cells) levels below 50,000/μL.^[1]^[2]

History

The effectiveness and safety of pacritinib were demonstrated in a study that included 63 participants with intermediate or high-risk primary or secondary myelofibrosis and low platelets who received pacritinib 200 mg twice daily or standard treatment.^[2] Effectiveness was determined based upon the proportion of participants who had a 35% or greater spleen volume reduction from baseline to week 24.^[2] Nine participants (29%) in the pacritinib treatment group had a 35% or greater spleen volume reduction, compared to one participant (3%) in the standard treatment group.^[2]

The U.S. Food and Drug Administration (FDA) granted the application for pacritinib priority review, fast track, and orphan drug designations.^[2]