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PHB2
Identifiers
Aliases	PHB2, BAP, BCAP37, Bap37, PNAS-141, REA, p22, hBAP, prohibitin 2, Prohibitin-2
External IDs	OMIM: 610704; MGI: 102520; HomoloGene: 5263; GeneCards: PHB2; OMA:PHB2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,970,780 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,693,913 bp
RNA expression pattern
	Top expressed in
	vulva; ; nipple; ; skin of arm; ; vastus lateralis muscle; ; triceps brachii muscle; ; left ovary; ; jejunal mucosa; ; skin of thigh; ; thymus; ; glutes;
	Top expressed in
	yolk sac; ; embryo; ; embryo; ; ventricular zone; ; tail of embryo; ; right kidney; ; lip; ; esophagus; ; muscle of thigh; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein N-terminus binding; amide binding; protein C-terminus binding; protein binding; estrogen receptor binding; sphingolipid binding;
Cellular component	cytoplasm; membrane; nuclear matrix; cell surface; mitochondrial outer membrane; mitochondrion; extracellular exosome; nucleus; cell periphery; mitochondrial inner membrane; axon; postsynaptic density; protein-containing complex; presynaptic active zone; glutamatergic synapse; GABA-ergic synapse;
Biological process	regulation of transcription, DNA-templated; mammary gland branching involved in thelarche; protein stabilization; regulation of branching involved in mammary gland duct morphogenesis; mitochondrion organization; negative regulation of mammary gland epithelial cell proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of exit from mitosis; mammary gland alveolus development; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; sister chromatid cohesion; positive regulation of cell cycle G1/S phase transition; positive regulation of ERK1 and ERK2 cascade; negative regulation of transcription, DNA-templated; negative regulation of intracellular estrogen receptor signaling pathway; regulation of complement activation; mitochondrial calcium ion transmembrane transport; response to wounding; negative regulation of apoptotic process; cellular response to retinoic acid; cellular response to hypoxia; protein import into nucleus; regulation of cytochrome-c oxidase activity;
	Sources:Amigo / QuickGO
Orthologs
	11331
	12034
	ENSG00000215021
	ENSMUSG00000004264
	Q99623
	O35129
	NM_001144831; NM_001267700
	NM_007531
	NP_001138303; NP_001254629
	NP_031557
	Wikidata
View/Edit Human	View/Edit Mouse

Prohibitin-2 is a protein that in humans is encoded by the PHB2 gene.^[5]^[6]^[7]

Interactions

PHB2 has been shown to interact with PTMA.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000215021 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004264 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Coates PJ, Nenutil R, McGregor A, Picksley SM, Crouch DH, Hall PA, Wright EG (Apr 2001). "Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence". Exp Cell Res. 265 (2): 262–73. doi:10.1006/excr.2001.5166. PMID 11302691.
^ Coates PJ, Jamieson DJ, Smart K, Prescott AR, Hall PA (Oct 1997). "The prohibitin family of mitochondrial proteins regulate replicative lifespan". Curr Biol. 7 (8): 607–10. Bibcode:1997CBio....7..607C. doi:10.1016/S0960-9822(06)00261-2. PMID 9259555. S2CID 7153605.
^ "Entrez Gene: PHB2 prohibitin 2".
^ Martini PG, Katzenellenbogen Benita S (Jun 2003). "Modulation of estrogen receptor activity by selective coregulators". J. Steroid Biochem. Mol. Biol. 85 (2–5): 117–22. doi:10.1016/S0960-0760(03)00207-3. ISSN 0960-0760. PMID 12943695. S2CID 32374864.