Oxadiazoles are a class of heterocyclic aromatic[1] chemical compounds of the azole family with the molecular formula C2H2N2O. There are four isomers of oxadiazole:
-
1,2,3-oxadiazole
-
1,2,4-oxadiazole
-
-
1,2,4-Oxadiazole, 1,2,5-oxadiazole, and 1,3,4-oxadiazole are all known and appear in a variety of pharmaceutical drugs including raltegravir, butalamine, fasiplon, oxolamine, and pleconaril. The 1,2,3-isomer is unstable and ring-opens to form the diazoketone tautomer;[2] however, it does exist within the unusual sydnone motif.[1]
In 2018, a compound called bis(1,2,4-oxadiazole)bis(methylene) dinitrate which might have 1.5 times the power of TNT was developed at the United States Army Research Laboratory (ARL) working with the Los Alamos National Laboratory.[3]
References
