The village was located north and west of the large village of Yaanga connected via a trail with the other village of Shevaanga.[6][7] Spanish priest José Zalvidea noted that the village was located "on the road from San Gabriel to Los Angeles."[4] This was a pre-Columbian trail that was used extensively prior to the arrival of the Spanish colonizers.[4]
Although evidence of the village has been largely destroyed, it has been proposed that El Sereno was established adjacent to Otsungna as an early Spanish colonial settlement in the Los Angeles area since Tongva laborers were essential to the construction of the city and early settlements were often constructed near preexisting Tongva villages.[2]