2ZFY, 3VON, 4DDG, 4DDI, 4DHZ, 4I6L, 4LDT
55611
107260
ENSG00000167770
ENSMUSG00000024767
Q96FW1
Q7TQI3
NM_017670
NM_134150
NP_060140
NP_598911
Ubiquitin thioesterase OTUB1 also known as otubain-1 is an enzyme that in humans is encoded by the OTUB1 gene.[5][6] Alternative splicing results in multiple transcript variants.
Otubain-1 is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains, being specific for lysine48 -linked polyubiquitin but not lysine63 -linked polyubiquitin.[7] It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth.[6]
OTUB1 has been shown to interact with RNF128[8] and GNB2L1.[7]
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
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