ONX-0801

ONX-0801
Clinical data
ATC code
  • none
Identifiers
  • N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC33H31N5O10
Molar mass657.636 g·mol−1
3D model (JSmol)
  • C#CCN(c1ccc(C(=O)N[C@@H](CCC(=O)N[C@H](CCC(=O)O)C(=O)O)C(=O)O)cc1)[C@H]4CCc3cc2nc(CO)[nH]c(=O)c2cc34

ONX-0801 (BGC 945) is an experimental drug that has been developed to target ovarian cancer.[1] It is a folate receptor alpha mediated thymidylate synthase inhibitor.[2][3]

ONX-0801 was originally developed by BTG and the Institute of Cancer Research in the UK, and subsequently licensed to Onyx Pharmaceuticals for clinical development. It is designed to selectively target tumour tissues of certain kinds of cancer.[4] It is poorly absorbed into most cells, but is actively transported by folate receptor alpha (FRα), which is usually only expressed at low levels in the apical membrane of some specialised tissues, but is expressed at much higher levels in some subtypes of ovarian cancer. This causes the drug to accumulate selectively in tumour tissues, while healthy tissues are only exposed to a much lower concentration.[5][6][7]

In 2017, it received press coverage following the successful completion of a Phase I clinical trial.[8][9][10]

References

  1. ^ "Ovarian cancer drug delivers 'very promising' results in early trial". The Institute of Cancer Research, London. 3 June 2017. Retrieved 2017-06-03.
  2. ^ "A Phase I trial of ONX-0801". Health Research Authority. 19 July 2013. Retrieved 2017-06-03.
  3. ^ Jarmuła A (November 2010). "Antifolate inhibitors of thymidylate synthase as anticancer drugs". Mini Reviews in Medicinal Chemistry. 10 (13): 1211–22. doi:10.2174/13895575110091211. PMID 20854257.
  4. ^ Gibbs DD, Theti DS, Wood N, Green M, Raynaud F, Valenti M, Forster MD, Mitchell F, Bavetsias V, Henderson E, Jackman AL (December 2005). "BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors". Cancer Research. 65 (24): 11721–8. doi:10.1158/0008-5472.CAN-05-2034. PMID 16357184.
  5. ^ Ng C, et al. Efficacy and tolerability of the thymidylate synthase (TS) inhibitor, BGC 945 is mediated through its selective uptake via the α-folate receptor (α-FR) in IGROV-1 human tumor xenografts. Cancer Res May 1, 2008 (68) (9 Supplement): 3289.
  6. ^ Ng CH, Jackman AL (2011). "Potential for α-folate receptor-targeted treatment for ovarian cancer.". Emerging Therapeutic Targets in Ovarian Cancer. New York, NY.: Springer. pp. 245–258.
  7. ^ Tochowicz A, Dalziel S, Eidam O, O'Connell JD, Griner S, Finer-Moore JS, Stroud RM (July 2013). "Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells". Journal of Medicinal Chemistry. 56 (13): 5446–55. doi:10.1021/jm400490e. PMC 3880649. PMID 23710599.
  8. ^ Warry R (2017-06-03). "Drug shrinks ovarian tumours in early trial". BBC News. Retrieved 2017-06-03.
  9. ^ "Researchers hail biggest breakthrough in advanced ovarian cancer for a decade". The Independent. 2017-06-02. Retrieved 2017-06-03.
  10. ^ Banerji U, Ingles Garces AH, Michalarea V, Ruddle R, Raynaud FI, Riisnaes R, Nava Rodrigues D, Tunariu N, Porter JC, Ward SE, Parmar M (2017). "An investigator-initiated phase I study of ONX-0801, a first-in-class alpha folate receptor targeted, small molecule thymidylate synthase inhibitor in solid tumors". Journal of Clinical Oncology. 35 (suppl): abstr 2503. doi:10.1200/JCO.2017.35.15_suppl.2503.


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