When modestly successful screenwriter Hudson Milbank descends into a strange mood in which he feels detached from the world around him and unable to connect with his surroundings, either physically or emotionally, he initially attributes it to a night of excessive cannabis use. His writing partner Tom is disturbed by the sudden change in Hudson's demeanor and urges him to seek psychiatric help.
Dr. Townsend diagnoses his condition as depersonalization disorder and prescribes various medications including Clonazepam, and when nothing seems to help Hudson consults Dr. Richmond, who also sees drugs, albeit divalproex sodium and others rather than Clonazepam, as the solution.
Hudson meets Sara, a beautiful young woman who finds him attractive and appealing and decides to introduce him to as many positive and compelling experiences as possible. Also trying to help him is yet another psychiatrist, Dr. Blaine, who initially resists his advances but ultimately has an affair with him before revealing she has serious issues of her own that require professional attention.
The Hollywood Reporter wrote, "There’s an obvious personal resonance to Goldberg’s screenplay, but the film never fully succeeds in its attempted straddling of psychological drama and broad comedy. Whenever we start to become emotionally involved in the main character’s angst, the filmmaker throws in gags to provide comic relief. The result is neither as broadly funny nor as moving as it intends to be, and the tonal imbalance is ultimately disorienting."[5] Wally Hammond of Time Out gave the film 3 out of 5 stars, writing that although the film starts to get repetitious and uncertain, "things liven up as Goldberg reverts to more conventional, romantic territory" and with the introduction of Collins' character.[8]