After five years overseas, star actress Tamae returns to Japan to reunite with her daughter Shigeko, whom she left behind with her then husband Atsumi in favour of her career. In her absence, Atsumi has married again, and the bond between Shigeko and her stepmother Masako has grown as strong as between a blood-related child and mother. When Atsumi's company goes bankrupt and his family is forced to move to lower-class surroundings, Tamae sees her chance to lure Shigeko away, but eventually has to accept that her wealth can't compensate for Shigeko's and Masako's mutual love.
Naruse biographer Catherine Russell linked No Blood Relation to other Naruse films of the same era like Three Sisters With Maiden Hearts, Wife! Be Like a Rose! and The Girl in the Rumor, by using the popular but controversial figure of the moga (modern Japanese girl with Western values and Western fashion style), who contrasted with another woman or sister.[4]