It includes a mural by New York City artist Bernard J. Steffen titled Neodesha's First Inhabitants. The mural is a tempera on pressed wood board mural "that depicts the friendly relations between the Osage Indians of southeastern Kansas and the early white settlers. On the right side of the canvas Osage Chief Little Bear waves to Dr. T. Blakeslee, a physician responsible for much of the peacefulness between the two cultures."[2]
The post office was deemed significant " for its historical association with the Treasury Department's Section program and for the artistic significance of the mural that it contains."[2]