Opoku played for Ventura County Fusion in USL League Two in 2022. He played and was named as the MVP as Fusion defeated the Long Island Rough Riders to win the USL League Two championship in 2022.[9] Opoku scored 11 goals in 16 appearances in 2022 for Ventura County Fusion.[10]
Leicester City and loan to Belgium
In January 2023, Opoku was reported to have signed for Premier League club Leicester City and loaned to Belgian club OH Leuven.[11][12] According to Sky Sports News, Opoku rejected the opportunity to be a top pick in the 2023 MLS SuperDraft in favour of the European move.[13] Opoku scored his first league goal for Leuven on April 8, 2023 in a 4–1 home win against KV Mechelen.[14] In April 2024, he suffered a double leg fracture playing for Leuven against Westerlo.[15]