NCOA7

NCOA7

Identifiers

NCOA7, ERAP140, ESNA1, NCOA7-AS, Nbla00052, Nbla10993, TLDC4, dJ187J11.3, nuclear receptor coactivator 7

External IDs

OMIM: 609752; MGI: 2444847; HomoloGene: 65245; GeneCards: NCOA7; OMA:NCOA7 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q22.31-q22.32	Start	125,781,161 bp^[1]
Band	6q22.31-q22.32	End	125,932,034 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 A4	Start	30,504,995 bp^[2]
Band	10\|10 A4	End	30,679,322 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

Brodmann area 23

pancreatic epithelial cell

mucosa of paranasal sinus

Brodmann area 46

middle temporal gyrus

endothelial cell

parietal pleura

visceral pleura

spinal ganglia

Pons

Top expressed in

cervix

ventral tegmental area

dorsomedial hypothalamic nucleus

medial vestibular nucleus

subiculum

superior colliculus

blood

dorsal tegmental nucleus

paraventricular nucleus of hypothalamus

lobe of cerebellum

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding nuclear receptor coactivator activity
Cellular component	intracellular anatomical structure nucleus
Biological process	regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of cellular response to oxidative stress negative regulation of peptidyl-cysteine S-nitrosylation negative regulation of oxidative stress-induced neuron death
Sources:Amigo / QuickGO

Species

Human

Mouse


135112


211329


ENSG00000111912


ENSMUSG00000039697


Q8NI08


Q6DFV7

RefSeq (mRNA)

NM_001122842 NM_001199619 NM_001199620 NM_001199621 NM_001199622
NM_181782


NM_001111267 NM_172495 NM_001358841 NM_001358842

RefSeq (protein)

NP_001116314 NP_001186548 NP_001186549 NP_001186550 NP_001186551
NP_861447


NP_001104737 NP_766083 NP_001345770 NP_001345771

Location (UCSC)

Chr 6: 125.78 – 125.93 Mb

Chr 10: 30.5 – 30.68 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Nuclear receptor coactivator 7 is a protein that in humans is encoded by the NCOA7 gene.^[5]^[6]

See also

Transcription coregulator

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111912 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039697 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shao W, Halachmi S, Brown M (Apr 2002). "ERAP140, a Conserved Tissue-Specific Nuclear Receptor Coactivator". Mol Cell Biol. 22 (10): 3358–72. doi:10.1128/MCB.22.10.3358-3372.2002. PMC 133794. PMID 11971969.
^ "Entrez Gene: NCOA7 nuclear receptor coactivator 7".

External links

NURSA C96

Further reading

Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–8. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
Halachmi S, Marden E, Martin G, et al. (1994). "Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription". Science. 264 (5164): 1455–8. Bibcode:1994Sci...264.1455H. doi:10.1126/science.8197458. PMID 8197458.
Nguyen TA, Hoivik D, Lee JE, Safe S (1999). "Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex". Arch. Biochem. Biophys. 367 (2): 250–7. doi:10.1006/abbi.1999.1282. PMID 10395741.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Rushing SR, Denison MS (2002). "The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression". Arch. Biochem. Biophys. 403 (2): 189–201. doi:10.1016/S0003-9861(02)00233-3. PMID 12139968.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Durand M, Kolpak A, Farrell T, et al. (2007). "The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins". BMC Cell Biol. 8: 13. doi:10.1186/1471-2121-8-13. PMC 1847813. PMID 17391516.

External links

NCOA7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v t e Transcription coregulators
Coactivators	ARA (54, 55, 70) BCAS3 CARM1 p300-CBP (EP300, CREBBP) CRTC (1, 2, 3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1, 2) PPARGC (1A, 1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140)
Corepressors	CTBP (1, 2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 RCOR1 Rb SIN3A SIN3B Tripartite motif family TRIM (24, 28, 33) NCOR1 NCOR2 (SMRT)
ATP-dependent remodeling factors	Chromatin Structure Remodeling (RSC) Complex SWI/SNF

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