MacInnes was educated at Portree High School on the Isle of Skye and followed this with a scholarship at George Watson's College, a private school in Morningside, Edinburgh.[2] After completing his Certificate of Sixth Year Studies, with one course in chemistry and four in mathematics, MacInnes gained admission and matriculated to the University of Edinburgh.[2] MacInnes had no plans after high school and initially wanted to lay bricks in Australia, but was unable to obtain a visa.[2]
His brother, Hector, is songwriter and guitarist for the band Injuns.[3] He also toured with Mylo throughout 2005 - serving his touring role on electronic drums.
Mylo released his debut album, Destroy Rock & Roll in 2004, on the Breastfed Recordings label, which he co-owns. He produced the album on a computer in his own bedroom. Mylo has said that his label turned down fellow Scottish DJ Calvin Harris.[5]
"Muscle Cars", the follow-up single to "Doctor Pressure", was a hit in the UK and European dance charts, reaching No. 1 on the UK Club Chart in November 2005, and No. 38 on the UK Singles Chart. The video that accompanied the single courted controversy as it featured two supposed Chinese spies – actually played by British actors Bruce Wang and Alex Liang – inventing an electronic fly to spy on the American president, George W. Bush. Mylo did not appear in the video.
In 2005, Mylo released a DJ mix titled Mylo's Rough Guide to Rave which was released as a covermount CD in Mixmag.[citation needed]
BBC Radio 1 played a world exclusive of a track by Mylo on 23 January 2009. The title of the track is unconfirmed, however Radio 1 referred to it as "I'm Back", because, as Annie Mac stated, "he (Mylo) sent it to us with the file titled I'm Back".[8] The same month, he released another DJ mix album cover mount in an issue of Mixmag, this time it was called The Return of Mylo, which contained his new song "Wings of Fire".[citation needed]