Samuel Solomon, a literature professor, experiences a recurring nightmare ever since the death of his girlfriend, in which a woman is brutally murdered. When the same woman in his dreams is found dead in reality, Solomon seeks an explanation. Rachel, a woman who claims to have also dreamed of the murder, helps Solomon in discovering the identity of the mysterious woman.
In late October 2014, it was announced that Balagueró came on board to direct the film.[3] An adaptation of José Carlos Somoza's novel The Lady Number Thirteen,[7]Muse is the third English-language film he directed following the 2002 film Darkness[3] and the 2005 film Fragile. Of the project, Balagueró said:
This is just the kind of story that has always fascinated me, as a movie-goer and as a director. The combination of the supernatural, seduction, macabre rituals and love is an explosive one and has all the elements required to make a truly terrifying movie.[3]
Principal photography began in December 2016,[7] shot on location in Belgium, the Republic of Ireland and Spain.[8]