In 1771, Moulvi Syed Qudratullah established a bazaar near the banks of the Manu River using his zamindari land. He started importing edible goods, such as fruits and vegetables opening up opportunities for people to purchase as well as sell. The location allowed easy access through river and land transport. The bazaar became the headquarters of South Sylhet subdivision in 1882. In 1891, Moulvibazar Govt. High School, the central school of Moulvibazar was established. The anti-British Khilafat Movement in 1921 also spread to Moulvibazar and campaigners that were present included Chittaranjan Das, Hussain Ahmed Madani and Sarojini Naidu. In 1932, the Ali Amzad Government Girls' High School was opened as a public school.
During the Indo-Pakistani War of 1971 and Bangladesh Liberation War, the Pakistan Army moved its 313rd Brigade from Sylhet to Moulvibazar and a battalion from the 313rd was kept at Sylhet to form the nucleus of the 202nd ad hoc Brigade.[1] On 20 December, a number of people were killed and wounded by mine explosions at the premises of the Moulvibazar Government High School.
On 22 February 1984, Moulvibazar became the headquarters of the newly established Moulvibazar Sadar Upazila, and the Moulvibazar District - which was renamed from South Sylhet. In 2005, the Saifur Rahman Stadium was established here, acting as a multi-use arena fitting 15,000 people.
According to the 2022 Bangladesh census, Moulvibazar city had a population of 68,303 and a literacy rate of 86.13%.[3]: 388–394
According to the 2011 Bangladesh census, Moulvibazar city had 10,840 households and a population of 56,537. 11,652 (20.61%) were under 10 years of age. Moulvibazar had a literacy rate (age 7 and over) of 65.03%, compared to the national average of 51.8%, and a sex ratio of 909 females per 1000 males. Ethnic population was 264 (0.47%).[2]