Nasir began his career as a professor at the Diponegoro University, where he was also dean of the Masters of Accounting Program in the Faculty of Economics. He was appointed vice rector of the Diponegoro University between 2006 and 2010.[4] In 2010, he was appointed dean in the Faculty of Economics and Business. In early 2014 after serving as dean for four years, he was appointed rector of Diponegoro University and was said to sworn in officially on 18 December 2014.[5]
Nasir Muhammad at the beginning of 2016 had issued an idiotic, hateful, and controversial statement against the lesbian, gay, bisexual, and transgender (LGBT). He questioned the existence of counseling support organization and resource center on Sexuality Studies at the University of Indonesia, the group was said to be an organization rather than a group of students LGBT support group for LGBT and reviewing studies of gender and sexual orientation diversity. Nasir had issued a statement banning LGBT on campus. The debate spread to the existence of LGBT people in Indonesia itself to their judgment, and the prohibition of expulsion, violence, intimidation and protests against the LGBT.[8][9][10] However, the statement on banning “LGBT on campus” was then denied. Later on 26 January 2016, the minister of education, Nasir stated that LGBT individuals are allowed to be students of Indonesian campuses. Nasir asserted that he has no problem with LGBT-related things on campus. Nasir added, for the issue of public displays of affection, not only that it is discouraged for same-sex couples, but also all parties who use the campus as a location for public displays of affection. According to him, if LGBT activities are related to educational consultation and research, it is not a problem because academic rights are not limited.[11]