Michel Goedert

Michel Goedert FRS, FMedSci is a Luxembourgish-British neuroscientist and former Head of Neurobiology, at the MRC Laboratory of Molecular Biology.^[1]

Goedert was born and raised in Luxembourg. After finishing his medical studies at the University of Basel in 1986, he started working at the Medical Research Council Laboratory of Molecular Biology affiliated with the University of Cambridge.

Goedert was awarded the Metlife Foundation Award for Medical Research in Alzheimer's Disease in 1996, the Potamkin Prize in 1998 and the European Grand Prix for Research by the Foundation for Research on Alzheimer's disease in 2014. In 2018 he was one of four recipients of the Grete Lundbeck European Brain Research Prize with the citation "For their groundbreaking research on the genetic and molecular basis of Alzheimer's disease, with far-reaching implications for the development of new therapeutic interventions as well as for the understanding of other neurodegenerative diseases of the brain".^[2] In 2019 he received the Royal Medal.^[3] and the Rainwater Charitable Foundation prize for outstanding innovation in neurodegenerative disorder research.^[4]

He is married to Maria Grazia Spillantini, a geneticist with whom he has one son, Thomas.

Research

Goedert's work combines biochemical, molecular biological and structural techniques to investigate common neurodegenerative diseases, including Alzheimer's and Parkinson's.^[5] His research focused on the abnormal filamentous inclusions that characterise Parkinson's and Alzheimer's, showing that the intracellular filaments of these diseases are made of either alpha-synuclein or tau protein.^[6] Goedert's team identified mutations in MAPT, the tau gene, that cause rare inherited forms of frontotemporal dementia with tau inclusions, establishing a central role for tau assembly in the disease.^[7]

Works

Irene Litvan, ed. (2005). "Neurodegenerative α-Synucleinopathies". Atypical Parkinsonian disorders: clinical and research aspects. Springer. p. 77. ISBN 978-1-58829-331-2.

References

^ "Michel Goedert". Alzforum. 19 October 2008. Retrieved 20 December 2019.
^ "The Brain Prize Winners 2018 - Lundbeckfonden - The Brain Prize". www.thebrainprize.org. Retrieved 20 December 2019.
^ Royal Medal 2019
^ The Rainwater Prize Program
^ "Biography Michel Goedert - Lundbeckfonden - The Brain Prize". www.thebrainprize.org. Retrieved 20 December 2019.
^ Avenue, Francis Crick. "Michel Goedert". MRC Laboratory of Molecular Biology. Retrieved 20 December 2019.
^ Paul Brackley (24 March 2018). "Winner of Brain Prize 2018, Prof Michel Goedert, on our best hope for tackling Alzheimer's disease". Cambridge Independent. Retrieved 20 December 2019.

External links

v t e Fellows of the Royal Society elected in 2000
Fellows	Michael Akam James Binney Brice Bosnich Cyrus Chothia Peter Cresswell Alan Davison John Douglas Denton Warren Ewens Michael Fasham Michael Anthony John Ferguson Chris Frith Michel Goedert Don Grierson Peter Gavin Hall Alexander Halliday Andrew Bruce Holmes Roy Jackson Bruce Arthur Joyce Simon Barry Laughlin Peter Francis Leadlay Anthony Charles Legon Robert Glanville Lloyd Robert Sinclair MacKay Thomas John Martin Kiyoshi Nagai Stuart Parkin Ole Holger Petersen M. S. Raghunathan T. V. Ramakrishnan Michael Alfred Robb Janet Rossant Patricia Simpson Harry Smith Peter Somogyi Martin Sweeting Brian Douglas Sykes James Till Paul Townsend Alan Andrew Watson Ian Wilson John Henry Woodhouse Adrian Wyatt
Foreign	Grigory Barenblatt Ronald Breslow Harry B. Gray Erwin Hahn Martin Karplus Mitsuhiro Yanagida
Honorary	John Maddox

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