On 26 February 2021, Arthur announced the release date for the single on his Twitter account.[4] In a press release, he said, "'Medicine' is an uplifting ode to self, to relationships, to community and connection, and to the healing, restorative powers of love over adversity. It is, you might say, the perfect song for spring 2021. The last year has forced many couple to look at themselves. It held a mirror up to us all, didn't it? And my partner was hugely supportive through that whole time. There are some pretty dark lyrics in there: 'When I’m suicidal, you don't let me spiral…'".[5] In an interview with the Official Charts Company, he said, "When I wrote it six months ago there was no vaccine or any end in sight to this. I definitely felt at the time that I'd like to get this song out as soon as possible, knowing that it would probably be another six months before the world would hear it. It's almost even more fitting now that there's a light at the end of the tunnel."[6]
Music video
A music video to accompany the release of "Medicine" was first released onto YouTube on 5 March 2021.[7]