Between 1996 and 2000, Closs headed the Radical Youth movement and in 2002 he was elected president of the Misiones national committee of the UCR.[1] In 2003, Closs and most of his fellow Misiones Radicals joined the Front for the Renewal of Concord in support of the re-election of incumbent Justicialist Party governor Carlos Rovira.[1]
Following the election, Rovira appointed Closs as chief of cabinet, and in 2005 he was elected to the Senate for the Front, becoming the youngest senator in the country at age 35. He sat in support of then President Néstor Kirchner.[1]