Manopole was born in 1971 as the fifth of six children.[1] Her mother worked as a teacher, while her father was an entrepreneur. She spent her childhood in Warrenton. After matriculating, she enrolled for a degree in marketing and management at the Central University of Technology. She could not finish the degree, as she had to help out at her father's business.[1] She later fulfilled a higher certificate in economic development at the University of the Western Cape in 2007.[1]
On 26 June 2020, Saul appointed Manopole as MEC for Land Reform, Agriculture and Nature Conservation and Environmental Affairs. She took office on the same day and succeeded Nomandla Bloem. Maruping Lekwene succeeded her as MEC for Health.[5]
Following the 2024 provincial election, Manopole remained as MEC for Land Reform, Agriculture and Nature Conservation and Environmental Affairs in the executive council led by Saul.[6]
Personal life
Manopole married in 1996. She then moved to Kimberley. She divorced in 2007 and has two sons from the marriage.[1]