She was married to Henry on 9 July 1292 which was arranged to settle a long-standing dispute with the Duke of Brabant over the Duchy of Limburg, with the duke abandoning his claim to Limburg at the time Margaret's marriage took place.[1] By all accounts, the marriage proved to be happy.[1] She became the Queen consort of Germany in 1308 when her husband was crowned king.
Margaret accompanied her husband on his Italy campaign, became ill during the siege of Brescia and died a few months later in Genoa, where she was buried in the church of San Francesco di Castelletto. Her death was recorded in the Gesta Baldewini Luczenburch in December 1311. The famous sculptor Giovanni Pisano was commissioned by the Emperor to create a monument in her memory in 1313 (parts of it are still preserved in Genoa, Museo di Sant'Agostino and Galleria Nazionale della Liguria in Palazzo Spinola).