In 1535, his father officially designated him as Prince of Portugal, taking the place of his eldest sister Infanta Maria Manuela. However, after his premature death at five years old, his younger brother Infante Filipe became the next Prince of Portugal.
Ancestry
Ancestors of Manuel, Hereditary Prince of Portugal (1531–1537)
* also an infante of Castile and León, Aragon, Sicily and Naples,§ also an infante of Spain and an archduke of Austria,# also an infante of Spain,‡ also an imperial prince of Brazil,¶ also a prince of Saxe-Coburg and Gotha, Duke in Saxony,◙ also a prince of Braganza,¤ title removed in 1920 as their parents' marriage was deemed undynastic,ƒ claimant infante
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