Manganese in biology

Reactive center of arginase with boronic acid inhibitor arginase – the manganese atoms are shown in yellow.

Manganese is an essential biological element in all organisms.[1] It is used in many enzymes and proteins.[2][3] It is essential in plants.[4]

Biochemistry

The classes of enzymes that have manganese cofactors include oxidoreductases, transferases, hydrolases, lyases, isomerases and ligases. Other enzymes containing manganese are arginase and Mn-containing superoxide dismutase (Mn-SOD). Also the enzyme class of reverse transcriptases of many retroviruses (though not lentiviruses such as HIV) contains manganese. Manganese-containing polypeptides are the diphtheria toxin, lectins and integrins.[2]

Biological role in humans

Manganese is an essential human dietary element. It is present as a coenzyme in several biological processes, which include macronutrient metabolism, bone formation, and free radical defense systems. It is a critical component in dozens of proteins and enzymes.[3] The human body contains about 12 mg of manganese, mostly in the bones. The soft tissue remainder is concentrated in the liver and kidneys.[5] In the human brain, the manganese is bound to manganese metalloproteins, most notably glutamine synthetase in astrocytes.[6]

Nutrition

Dietary recommendations

Current AIs of Mn by age group and sex[7]
Males Females
Age AI (mg/day) Age AI (mg/day)
1–3 1.2 1–3 1.2
4–8 1.5 4–8 1.5
9–13 1.9 9–13 1.6
14–18 2.2 14–18 1.6
≥19 2.3 ≥19 1.8
pregnant: 2
lactating: 2.6

The U.S. Institute of Medicine (IOM) updated Estimated Average Requirements (EARs) and Recommended Dietary Allowances (RDAs) for minerals in 2001. For manganese, there was not sufficient information to set EARs and RDAs, so needs are described as estimates for Adequate Intakes (AIs). As for safety, the IOM sets Tolerable upper intake levels (ULs) for vitamins and minerals when evidence is sufficient. In the case of manganese, the adult UL is set at 11 mg/day. Collectively the EARs, RDAs, AIs and ULs are referred to as Dietary Reference Intakes (DRIs).[7] Manganese deficiency is rare.[8]

The European Food Safety Authority (EFSA) refers to the collective set of information as Dietary Reference Values, with Population Reference Intake (PRI) instead of RDA, and Average Requirement instead of EAR. AI and UL are defined the same as in the United States. For people ages 15 and older, the AI is set at 3.0 mg/day. AIs for pregnancy and lactation is 3.0 mg/day. For children ages 1–14 years, the AIs increase with age from 0.5 to 2.0 mg/day. The adult AIs are higher than the U.S. RDAs.[9] The EFSA reviewed the same safety question and decided that there was insufficient information to set a UL.[10]

For U.S. food and dietary supplement labeling purposes, the amount in a serving is expressed as a percent of Daily Value (%DV). For manganese labeling purposes, 100% of the Daily Value was 2.0 mg, but as of 27 May 2016 it was revised to 2.3 mg to bring it into agreement with the RDA.[11][12] A table of the old and new adult daily values is provided at Reference Daily Intake.

Toxicity

Excessive exposure or intake may lead to a condition known as manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and symptoms similar to Parkinson's disease.[5][13]

Deficiency

Main article: Manganese deficiency

Manganese deficiency in humans, which is rare, results in a number of medical problems. Many common vitamin and mineral supplement products fail to include manganese in their compositions. Relatively high dietary intake of other minerals such as iron, magnesium, and calcium may inhibit the proper intake of manganese. A deficiency of manganese causes skeletal deformation in animals and inhibits the production of collagen in wound healing.

Toxicity in marine life

Many enzymatic systems need Mn to function, but in high levels, Mn can become toxic. One environmental reason Mn levels can increase in seawater is when hypoxic periods occur.[14] Since 1990 there have been reports of Mn accumulation in marine organisms including fish, crustaceans, mollusks, and echinoderms. Specific tissues are targets in different species, including the gills, brain, blood, kidney, and liver/hepatopancreas. Physiological effects have been reported in these species. Mn can affect the renewal of immunocytes and their functionality, such as phagocytosis and activation of pro-phenoloxidase, suppressing the organisms' immune systems. This causes the organisms to be more susceptible to infections. As climate change occurs, pathogen distributions increase, and in order for organisms to survive and defend themselves against these pathogens, they need a healthy, strong immune system. If their systems are compromised from high Mn levels, they will not be able to fight off these pathogens and die.[15]

Biological role in bacteria

Mn-SOD is the type of SOD present in eukaryotic mitochondria, and also in most bacteria (this fact is in keeping with the bacterial-origin theory of mitochondria). The Mn-SOD enzyme is probably one of the most ancient, for nearly all organisms living in the presence of oxygen use it to deal with the toxic effects of superoxide (O−
2), formed from the 1-electron reduction of dioxygen. The exceptions, which are all bacteria, include Lactobacillus plantarum and related lactobacilli, which use a different nonenzymatic mechanism with manganese (Mn2+) ions complexed with polyphosphate, suggesting a path of evolution for this function in aerobic life.

Biological role in plants

See also: Manganese deficiency (plant)

Manganese is also important in photosynthetic oxygen evolution in chloroplasts in plants. The oxygen-evolving complex (OEC) is a part of photosystem II contained in the thylakoid membranes of chloroplasts; it is responsible for the terminal photooxidation of water during the light reactions of photosynthesis, and has a metalloenzyme core containing four atoms of manganese.[16][17] To fulfill this requirement, most broad-spectrum plant fertilizers contain manganese.

References

  1. ^ Li, Longman; Yang, Xiaobo (2018). "The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions". Oxidative Medicine and Cellular Longevity. 2018: 1–11. doi:10.1155/2018/7580707. PMC 5907490. PMID 29849912.
  2. ^ a b Rice, Derek B.; Massie, Allyssa A.; Jackson, Timothy A. (2017). "Manganese–Oxygen Intermediates in O–O Bond Activation and Hydrogen-Atom Transfer Reactions". Accounts of Chemical Research. 50 (11): 2706–2717. doi:10.1021/acs.accounts.7b00343. PMID 29064667.
  3. ^ a b Erikson, K. M.; Aschner, M. (2019). "Manganese: Its Role in Disease and Health". Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic. Vol. 19. pp. 253–266. doi:10.1515/9783110527872-016. ISBN 978-3-11-052787-2. PMID 30855111. S2CID 73725546. {{cite book}}: |journal= ignored (help)
  4. ^ Schmidt, Sidsel Birkelund; Husted, Søren (27 September 2019). "The Biochemical Properties of Manganese in Plants". Plants. 8 (10): 381. doi:10.3390/plants8100381. PMC 6843630. PMID 31569811.
  5. ^ a b Emsley, John (2001). "Manganese". Nature's Building Blocks: An A-Z Guide to the Elements. Oxford, UK: Oxford University Press. pp. 249–253. ISBN 978-0-19-850340-8.
  6. ^ Takeda, A. (2003). "Manganese action in brain function". Brain Research Reviews. 41 (1): 79–87. doi:10.1016/S0165-0173(02)00234-5. PMID 12505649. S2CID 1922613.
  7. ^ a b Institute of Medicine (US) Panel on Micronutrients (2001). "Manganese". Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Chromium, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Chromium. National Academy Press. pp. 394–419. ISBN 978-0-309-07279-3. PMID 25057538.
  8. ^ See "Manganese". Micronutrient Information Center. Oregon State University Linus Pauling Institute. 2014-04-23.
  9. ^ "Overview on Dietary Reference Values for the EU population as derived by the EFSA Panel on Dietetic Products, Nutrition and Allergies" (PDF). 2017.
  10. ^ Tolerable Upper Intake Levels For Vitamins And Minerals (PDF), European Food Safety Authority, 2006
  11. ^ "Federal Register May 27, 2016 Food Labeling: Revision of the Nutrition and Supplement Facts Labels. FR page 33982" (PDF).
  12. ^ "Daily Value Reference of the Dietary Supplement Label Database (DSLD)". Dietary Supplement Label Database (DSLD). Archived from the original on 7 April 2020. Retrieved 16 May 2020.
  13. ^ Silva Avila, Daiana; Luiz Puntel, Robson; Aschner, Michael (2013). "Manganese in Health and Disease". In Astrid Sigel; Helmut Sigel; Roland K. O. Sigel (eds.). Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. Vol. 13. Springer. pp. 199–227. doi:10.1007/978-94-007-7500-8_7. ISBN 978-94-007-7499-5. PMC 6589086. PMID 24470093.
  14. ^ Hernroth, Bodil; Krång, Anna-Sara; Baden, Susanne (February 2015). "Bacteriostatic suppression in Norway lobster (Nephrops norvegicus) exposed to manganese or hypoxia under pressure of ocean acidification". Aquatic Toxicology. 159: 217–224. Bibcode:2015AqTox.159..217H. doi:10.1016/j.aquatox.2014.11.025. PMID 25553539.
  15. ^ Hernroth, Bodil; Tassidis, Helena; Baden, Susanne P. (March 2020). "Immunosuppression of aquatic organisms exposed to elevated levels of manganese: From global to molecular perspective". Developmental & Comparative Immunology. 104: 103536. doi:10.1016/j.dci.2019.103536. PMID 31705914. S2CID 207935992.
  16. ^ Umena, Yasufumi; Kawakami, Keisuke; Shen, Jian-Ren; Kamiya, Nobuo (May 2011). "Crystal structure of oxygen-evolving photosystem II at a resolution of 1.9 Å". Nature. 473 (7345): 55–60. Bibcode:2011Natur.473...55U. doi:10.1038/nature09913. PMID 21499260. S2CID 205224374.
  17. ^ Charles Dismukes, G.; Van Willigen, Rogier T. (2006). "Manganese: The Oxygen-Evolving Complex & Models". Encyclopedia of Inorganic Chemistry. doi:10.1002/0470862106.ia128. ISBN 978-0-470-86078-6.