Pichot rose to fame in 2008, when she uploaded a video to YouTube after breaking up with her boyfriend, titled "La loca de mierda" (roughly translated "The Fucking Crazy Woman").[3] After a series of humorous La Loca de Mierda YouTube videos were viewed by millions of people, MTV Latin America hired Pichot to broadcast her videos on its website.[4]
After having become an Internet celebrity, Pichot presented her stand-up show Concheta pero con gracia (roughly translated "posh but funny",[4]) and has been performing with Ezequiel Campa in the stand-up comedy show Campa-Pichot since 2010.[5]
In 2011 Pichot joined the cast of El hombre de tu vida, an Argentine comedy series created by Juan José Campanella that aired in Telefe.[6]
In 2013, she created and acted in two other series: Jorge, an 8-episode series on TV Publica, and Por ahora, a 13-episode series on Cosmopolitan TV.[9]
In 2018, Pichot had a stand up special, Estupidez compleja (Complex Stupidity), air on Netflix. The show is about feminism and Argentine culture.[10]
In 2019, she published Enojate, Hermana, a compilation of more than 30 of her own articles published in Página 12 between 2017 and 2019 referring to gender and feminism issues.[11]
Family
She is the cousin of Argentine rugby player Agustín Pichot. In addition, Malena and Leandro Lopatín have a son together named Rafael Lopatín Pichot, who was born on June 12, 2023.