MS4A3

MS4A3
Identifiers
AliasesMS4A3, CD20L, HTM4, membrane spanning 4-domains A3
External IDsOMIM: 606498; MGI: 2158468; HomoloGene: 4472; GeneCards: MS4A3; OMA:MS4A3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001031666
NM_001031809
NM_006138

NM_133246

RefSeq (protein)

NP_001026836
NP_001026979
NP_006129

NP_573509

Location (UCSC)Chr 11: 60.06 – 60.07 MbChr 19: 11.61 – 11.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene.[5][6]

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.[6]

Interactions

MS4A3 has been shown to interact with CDKN3.[7]

References

  1. ^ a b c ENSG00000284903 GRCh38: Ensembl release 89: ENSG00000149516, ENSG00000284903Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024681Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Adra CN, Lelias JM, Kobayashi H, Kaghad M, Morrison P, Rowley JD, Lim B (Nov 1994). "Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions". Proc Natl Acad Sci U S A. 91 (21): 10178–82. Bibcode:1994PNAS...9110178A. doi:10.1073/pnas.91.21.10178. PMC 44981. PMID 7524084.
  6. ^ a b "Entrez Gene: MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)".
  7. ^ Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1). United States: 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350.

Further reading