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KMT2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UVM, 4ERZ, 4PZI
Identifiers
Aliases	KMT2B, HRX2, MLL1B, MLL2, MLL4, TRX2, WBP-7, WBP7, CXXC10, lysine methyltransferase 2B, DYT28
External IDs	OMIM: 606834; MGI: 109565; HomoloGene: 22838; GeneCards: KMT2B; OMA:KMT2B - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,738,880 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,288,151 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right hemisphere of cerebellum; ; anterior pituitary; ; granulocyte; ; skin of leg; ; right lobe of thyroid gland; ; skin of abdomen; ; left lobe of thyroid gland; ; gastric mucosa;
	Top expressed in
	secondary oocyte; ; genital tubercle; ; tail of embryo; ; zygote; ; hand; ; neural layer of retina; ; otic vesicle; ; mesenteric lymph nodes; ; granulocyte; ; ventricular zone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; DNA binding; DNA-binding transcription factor activity; zinc ion binding; metal ion binding; protein binding; histone-lysine N-methyltransferase activity; histone methyltransferase activity (H3-K4 specific); DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus; histone methyltransferase complex;
Biological process	regulation of transcription, DNA-templated; histone H3-K4 trimethylation; regulation of histone H3-K4 methylation; memory; transcription, DNA-templated; methylation; ovarian follicle development; histone lysine methylation; ovulation; oocyte differentiation; histone H3-K4 methylation; regulation of megakaryocyte differentiation; chromatin organization; regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	9757
	75410
	ENSG00000272333
	ENSMUSG00000006307
	Q9UMN6
	O08550
	NM_014727
	NM_001290573; NM_029274
	NP_055542
	NP_001277502; NP_083550
	Wikidata
View/Edit Human	View/Edit Mouse

Myeloid/lymphoid or mixed-lineage leukemia 4, also known as MLL4, is a human gene.^[5]

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.^[5]