MCF-7

MCF-7 Cells

MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old White woman.[1] MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers.[2] The Michigan Cancer Foundation is now known as the Barbara Ann Karmanos Cancer Institute.[3]

Prior to MCF-7, it was not possible for cancer researchers to obtain a mammary cell line that was capable of living longer than a few months.[4]

The patient, Frances Mallon died in 1970 due to metastatic breast cancer.[5] Her cells were the source of much of current knowledge about breast cancer.[2][6] At the time of sampling, she was a nun in the convent of Immaculate Heart of Mary in Monroe, Michigan under the name of Sister Catherine Frances.

MCF-7 and two other breast cancer cell lines, named T-47D and MDA-MB-231, account for more than two-thirds of all abstracts reporting studies on mentioned breast cancer cell lines, as concluded from a Medline-based survey.[7]

Characteristics of MCF-7 cells

MCF-7 cells have the following characteristics:[2][6][7][8][9][10]

This cell line retained several characteristics of differentiated mammary epithelium, including the ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes.[citation needed]

Tumor necrosis factor alpha (TNF alpha) inhibits the growth of MCF-7 breast cancer cells. Treatment with anti-estrogens can modulate the secretion of insulin-like growth factor binding proteins. Omega-3 and 6 fatty acids such as EPA, DHA and AA has been reported to inhibit MCF-7 cell line growth and proliferation.[13]

PIK3CA helical mutations were identified in MCF-7,[14] but with low AKT activation.[15]

References

  1. ^ Lee, Adrian V.; et al. (1 July 2015). "MCF-7 Cells—Changing the Course of Breast Cancer Research and Care for 45 Years". Journal of the National Cancer Institute. 107 (7): djv073. doi:10.1093/jnci/djv073. PMID 25828948.
  2. ^ a b c Soule, HD; Vazquez J; Long A; Albert S; Brennan M. (1973). "A human cell line from a pleural effusion derived from a breast carcinoma". Journal of the National Cancer Institute. 51 (5): 1409–1416. doi:10.1093/jnci/51.5.1409. PMID 4357757.
  3. ^ http://www.cancer.gov "NCI Cancer Bulletin for April 29, 2008 - National Cancer Institute". Archived from the original on 2010-05-27. Retrieved 2010-04-28. Retrieved on 2010-04-28
  4. ^ Glodek, Cass, Ph.D., "A History of the Michigan Cancer Foundation, the Beginnings & Growth of Detroit's Anticancer Movement," 1990, page 68, Michigan Cancer Foundation, Detroit.
  5. ^ Lee, A. V.; Oesterreich, S.; Davidson, N. E. (2015-03-31). "MCF-7 Cells--Changing the Course of Breast Cancer Research and Care for 45 Years". JNCI Journal of the National Cancer Institute. 107 (7): djv073–djv073. doi:10.1093/jnci/djv073. ISSN 0027-8874.
  6. ^ a b Levenson, AS; Jordan VC. (1997). "MCF-7: the first hormone-responsive breast cancer cell line". Cancer Research. 57 (15): 3071–3078. PMID 9242427.
  7. ^ a b Lacroix, M; Leclercq G. (2004). "Relevance of breast cancer cell lines as models for breast tumours: an update". Breast Research and Treatment. 83 (3): 249–289. doi:10.1023/B:BREA.0000014042.54925.cc. PMID 14758095. S2CID 207628369.
  8. ^ Ross, DT; Perou CM. (2001). "A comparison of gene expression signatures from breast tumors and breast tissue derived cell lines". Disease Markers. 17 (2): 99–109. doi:10.1155/2001/850531. PMC 3850857. PMID 11673656.
  9. ^ Charafe-Jauffret, E; Ginestier C; Monville F; Finetti P; Adelaide J; Cervera N; Fekairi S; Xerri L; Jacquemier J; Birnbaum D; Bertucci F. (2006). "Gene expression profiling of breast cell lines identifies potential new basal markers". Oncogene. 25 (15): 2273–2284. doi:10.1038/sj.onc.1209254. PMID 16288205.
  10. ^ Lacroix, M; Toillon RA; Leclercq G. (2006). "p53 and breast cancer, an update". Endocrine-Related Cancer. 13 (2). Bioscientifica: 293–325. doi:10.1677/erc.1.01172. PMID 16728565.
  11. ^ Fanelli, Alex (2016). "MCF-7 Cells: human breast adenocarcinoma cell line". Retrieved 3 December 2017.
  12. ^ Sflomos, George; Dormoy, Valerian; Metsalu, Tauno; Jeitziner, Rachel; Battista, Laura; Scabia, Valentina; Raffoul, Wassim; Delaloye, Jean-Francois; Treboux, Assya (2016). "A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response". Cancer Cell. 29 (3): 407–422. doi:10.1016/j.ccell.2016.02.002. PMID 26947176.
  13. ^ Mansara, Prakash P.; Deshpande, Rashmi A.; Vaidya, Milind M.; Kaul-Ghanekar, Ruchika (1 September 2015). "Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231". PLOS ONE. 10 (9): e0136542. Bibcode:2015PLoSO..1036542M. doi:10.1371/journal.pone.0136542. ISSN 1932-6203. PMC 4556657. PMID 26325577.
  14. ^ Cosmic. "COSMIC: Sample overview for 1289391". cancer.sanger.ac.uk. Retrieved 2017-05-10.
  15. ^ Vasudevan, Krishna M.; Barbie, David A.; Davies, Michael A.; Rabinovsky, Rosalia; McNear, Chontelle J.; Kim, Jessica J.; Hennessy, Bryan T.; Tseng, Hsiuyi; Pochanard, Panisa (2009-07-07). "AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer". Cancer Cell. 16 (1): 21–32. doi:10.1016/j.ccr.2009.04.012. ISSN 1878-3686. PMC 2752826. PMID 19573809.
Wikimedia Commons has media related to MCF-7 cells.

Read other articles:

Jules Brasseur

Jules Brasseur Jules Brasseur adalah seorang pemeran Prancis dan penyanyi, lahir pada 1829 di Paris dan meninggal di kota yang sama pada 1890, dia sangat populer di Paris dan sekitar Prancis pada paruh kedua abad ke-19. Nama lahirnya adalah Jules-Victor-Alexandre Dumont,[1] ayahandanya adalah seorang pedagang kayu dan mengharapkannya menjadi seorang pebisnis; sebuah posisi telah disiapkan untuknya sebagai asisten pembuat sarung tangan di sebuah toko di Chaussée d'Antin. Putranya Albe...

 

Ali I (Bavandid ruler)

Ispahbadh of the Bavand dynasty Ali IIspahbadh of the Bavand dynastyReign1118-1142PredecessorRustam IIISuccessorShah Ghazi Rustam IVBorn1070MazandaranDied1145 (aged 78)Tamisha, MazandaranBurialSariSpouseUnnamed Seljuq princessIssueShah Ghazi Rustam IVTaj al-Muluk MardavijHouseBavand dynastyFatherShahriyar IVReligionTwelver Shia Islam Ali I (Persian: علی), was the ruler of the Bavand dynasty from 1118 to 1142. He was the uncle and successor of Rustam III. Rise to the throne Ali I was the so...

 

Joan Sebastian

Joan Sebastian Joan Sebastian en 2009.Información personalNombre de nacimiento José Manuel Figueroa FigueroaApodo el Rey del Jaripeo[1]​el Poeta de Juliantla[2]​el Huracán del Sur[3]​Nacimiento 8 de abril de 1951Juliantla, Guerrero (México)Fallecimiento 13 de julio de 2015 (64 años)Juliantla, Guerrero (México)Causa de muerte Cáncer óseo primario[4]​Sepultura Mausoleo de Joan Sebastianen Juliantla, Guerrero[5]​Nacionalidad MexicanaReligión Católico[...

Basanti Dulal Nagchaudhuri

Basanti Dulal NagchaudhuriLahir(1917-09-06)6 September 1917[1]Desa Barodi, Distrik Dhaka, India BritaniaMeninggal25 Juni 2006(2006-06-25) (umur 88)[2]Sebab meninggalStrokeKebangsaanIndiaPendidikanUniversitas Hindu Banaras Universitas Allahabad Universitas California, BerkeleyAlmamaterUniversitas Hindu BanarasPekerjaanFisikawanTempat kerjaUniversitas Kalkuta Institut Fisika Nuklir Saha Pemerintah India Komisi Perencanaan Universitas Jawaharlal NehruOrganisasiAkademi ...

 

When Will You Marry?

When Will You Marry?Bahasa Tahiti: Nafea faa ipoipo?SenimanPaul GauguinTahun1892TipeLukisan minyak di kanvasUkuran101 x 77 sentimeter (40 in × 30 in)LokasiFondation Beyeler, Riehen, Swiss (sampai 2015) When Will You Marry? (bahasa Tahiti: Nafea faa ipoipo?) adalah lukisan minyak tahun 1892 karya seniman Pasca-Impresionis Prancis Paul Gauguin. Dipinjamkan ke Kunstmuseum di Basel, Swiss selama hampir setengah abad, lukisan ini dijual secara pribadi oleh keluarga Rudolf Staec...

 

Roger Allam

British actor (born 1953) Roger AllamAllam in 2009BornRoger William Allam (1953-10-26) 26 October 1953 (age 70)Bow, London, EnglandOccupationActorYears active1976–presentSpouseRebecca SaireChildren2Websiteall-allam.com Roger William Allam (born 26 October 1953) is a British actor, who has performed on stage, in film, on television and radio. He played Inspector Javert in the original London production of the stage musical Les Misérables, First Officer Douglas Richardson in the aw...

Xplora

Television channel XploraCountrySpainBroadcast areaSpainAndorraHeadquartersMadridProgrammingLanguage(s)SpanishOwnershipOwnerAtresmediaSister channelsAntena 3NeoxNovaNitroAntena 3 HDlaSextalaSexta3laSexta HDGol TVHistoryLaunched1 May 2012Closed5 May 2014LinksWebsitewww.lasexta.com Xplora was a Spanish TV channel owned by Atresmedia. The channel started broadcasting on 1 May 2012, replacing laSexta2 due its low ratings. On 5 May 2014, the channel ceased broadcasting. Most of its programming we...

 

WHO-DT

NBC affiliate in Des Moines, Iowa This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: WHO-DT – news · newspapers · books · scholar · JSTOR (January 2013) (Learn how and when to remove this template message) WHO-DTDes Moines, IowaUnited StatesChannelsDigital: 13 (VHF)Virtual: 13BrandingWHO 13 (call letters are pr...

 

Ueno–Tokyo Line

JR East railway that runs in Tokyo, Japan Ueno–Tokyo LineAn E233-3000 series EMU, one of the train types used on the Ueno–Tokyo LineOverviewNative name上野東京ラインStatusOperationalLocaleTokyoServiceTypeCommuter railOperator(s) JR EastDaily ridership320,229 (daily, 2015)[1]HistoryOpened14 March 2015TechnicalTrack gauge1,067 mm (3 ft 6 in)Electrification1,500 V DC overhead catenary The Ueno–Tokyo Line (Japanese: 上野東京ライン, romanized: U...

Антитринитаризм

ХристианствоБиблия Ветхий Завет Новый Завет Евангелие Десять заповедей Нагорная проповедь Апокрифы Бог, Троица Бог Отец Иисус Христос Святой Дух История христианства Апостолы Хронология христианства Раннее христианство Гностическое христианство Вселенские соборы Н...

 

Double monastery

Monastery combining separate communities of monks and nuns Fahr Convent in Switzerland, still part of a double monastery with Einsiedeln Abbey, though not sharing a site A double monastery (also dual monastery or double house) is a monastery combining separate communities of monks and of nuns, joined in one institution to share one church and other facilities.[1][a] The practice is believed to have started in the East at the dawn of monasticism. It is considered more common in...

 

西遊記大結局之仙履奇緣

本條目存在以下問題，請協助改善本條目或在討論頁針對議題發表看法。 此條目需要編修，以確保文法、用詞、语气、格式、標點等使用恰当。 (2013年8月6日)請按照校對指引，幫助编辑這個條目。（幫助、討論） 此條目剧情、虛構用語或人物介紹过长过细，需清理无关故事主轴的细节、用語和角色介紹。 (2020年10月6日)劇情、用語和人物介紹都只是用於了解故事主軸，輔助�...

Grolier

Publisher of educational and reference books For other uses, see Grolier (disambiguation). GrolierParent companyScholasticFounded1909; 115 years ago (1909)FounderWalter M. JacksonDefunct2000; 24 years ago (2000)Country of originUnited StatesHeadquarters locationDanbury, ConnecticutPublication typesBooksOfficial websitego.scholastic.com Grolier was one of the largest American publishers of general encyclopedias, including The Book of Knowledge (1910), The Ne...

 

Oregon Public Utility Commission

Oregon Public Utility CommissionAgency overviewHeadquartersSalem, OregonWebsitewww.oregon.gov/PUC The Oregon Public Utility Commission (PUC) is the chief electric, gas and telephone utility regulatory agency of the government of the U.S. state of Oregon. It sets rates and establishes rules of operation for the state's investor-owned utility companies. With respect to publicly owned utility districts and cooperatives, its authority is limited to safety regulations. The first regulation of a p...

 

FareFuturo

Italian political foundation FareFuturoAbbreviationFFFormation15 May 2007; 17 years ago (2007-05-15)Legal statusFoundationPurposePolitical activismHeadquartersVia Vittoria Colonna, 1100193 RomePresidentAdolfo UrsoMain organCharta minutaParent organizationFuture and Freedom (2011–2013)FareItalia (2013–present)Websitefarefuturofondazione.it FareFuturo (meaning MakeFuture, FF) is a right-wing think tank, which intend develop a new liberal conservative and secular-minded rig...

Volvo Trucks

Swedish truck manufacturer Volvo TrucksCompany typeDivisionIndustryAutomotiveFounded1928HeadquartersGothenburg, SwedenAreas servedWorldwideKey peopleRoger Alm (President)ParentVolvoWebsitevolvotrucks.com A 2013 model Volvo FH16. The Volvo FH series was introduced in 1993 and is Volvo Trucks' most commercially successful truck. Volvo FM500 in Taiwan Volvo Trucks (Swedish: Volvo Lastvagnar) is a truck manufacturing division of Volvo based in Gothenburg, Sweden. Volvo Trucks was a separate compa...

 

VTB Bank

VTB BankKode emitenMCX: VTBRLSE: VTBRIndustriPerbankanDidirikan1990KantorpusatMoskwa, Rusia, RusiaWilayah operasiSeluruh duniaTokohkunciAndrey L. KostinJasaJasa keuanganPendapatanRUB 405.4 milyar(30 Juni 2013 IFRS Results)[1]Laba bersihRUB 27.6 milyar(30 Juni 2013 IFRS Results)[1]Total asetRUB 9.402,3 milyar(31 Maret 2014 IFRS Results)[1]Total ekuitasRUB 952.4 milyar(31 Maret 2014 IFRS Results)[1]Karyawan95.161 [1]Situs webhttp://www.vtb.com VTB Ba...

 

Daftar duta besar Namibia untuk Indonesia

Duta Besar Namibia untuk Indonesia Berikut adalah daftar duta besar Republik Namibia untuk Republik Indonesia. Nama Kredensial Selesai tugas Ref. Gebhard Benjamin Kandanga 9 Maret 2012 [1][cat. 1] Anne Namakau Mutelo 4 Oktober 2016 [2][cat. 1] Catatan ^ a b Berkedudukan di Kuala Lumpur. Lihat pula Daftar Duta Besar Indonesia untuk Namibia Daftar duta besar untuk Indonesia Referensi ^ Liu, Hindra (9 Maret 2012). Presiden Terima Surat Kepercayaan dari Dubes Asing...

John Adler

American politician and lawyer (1959–2011) For the American neurosurgeon, see John R. Adler. John AdlerMember of the U.S. House of Representativesfrom New Jersey's 3rd districtIn officeJanuary 3, 2009 – January 3, 2011Preceded byJim SaxtonSucceeded byJon RunyanMember of the New Jersey Senatefrom the 6th districtIn officeJanuary 14, 1992 – January 3, 2009Preceded byLee B. Laskin[1]Succeeded byJames Beach[2] Personal detailsBornJohn Herbert Ad...

 

Shape of You

Shape of YouSingel oleh Ed Sheerandari album ÷Dirilis6 Januari 2017 (2017-01-06)Studio Rokstone (London) Gingerbread Man (Suffolk dan London) Genre Pop dancehall R&B tropical house[1] Durasi3:54[2]Label Asylum Atlantic Pencipta Ed Sheeran Johnny McDaid Kandi Burruss Kevin She'kspere Briggs Steve Mac Tameka Cottle Produser Ed Sheeran Steve Mac Kronologi singel Ed Sheeran Lay It All on Me (2015) Castle on the Hill / Shape of You (2017) Galway Girl (2017) Video musikSha...