Wedler had her debut in 2015, starring in Niklaus Hilbers' film Amateur Teens. In an interview, she said she applied for her first movie role at 14 years of age "just like that".[2] Since then, acting has fascinated her, especially embodying characters with dark sides.[2] At the age of 17, she starred in Blue My Mind, in which her character moves to a new school and indulges in a lifestyle of excess involving wild parties, drugs, and sex. She tells in retrospect: "This role affected me psychologically and demanded everything from me".[4][2]
In August 2020, Netflix released the techno-thriller series Biohackers. Wedler holds the lead role on the show, in which she seeks revenge for the death of her twin brother.[5] A second season was released in July 2021.[6]