PROFILPELAJAR.COM

Lonafarnib
Clinical data
Trade names	Zokinvy
Other names	SCH 66336
License data	US DailyMed: Lonafarnib;
Routes of; administration	By mouth
ATC code	A16AX20 (WHO) ;
Legal status
Legal status	US: ℞-only; EU: Rx-only;
Identifiers
	IUPAC name 4-(2-{4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]piperidin-1-yl}-2-oxoethyl)piperidine-1-carboxamide;
CAS Number	193275-84-2 ;
PubChem CID	148195;
IUPHAR/BPS	8024;
DrugBank	DB06448;
ChemSpider	130645 ;
UNII	IOW153004F;
KEGG	D04768 ;
ChEBI	CHEBI:47097 ;
ChEMBL	ChEMBL298734 ;
PDB ligand	336 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID90172927 ;
ECHA InfoCard	100.204.509
Chemical and physical data
Formula	C27H31Br2ClN4O2
Molar mass	638.83 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C=12CCC=3C=C(C=C(C3[C@H](C1N=CC(=C2)Br)C4CCN(CC4)C(=O)CC5CCN(CC5)C(N)=O)Br)Cl;
	InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1 ; Key:DHMTURDWPRKSOA-RUZDIDTESA-N ;

Lonafarnib, sold under the brand name Zokinvy, is a medication used to reduce the risk of death due to Hutchinson-Gilford progeria syndrome and for the treatment of certain processing-deficient progeroid laminopathies in people one year of age and older.^[3]^[4] It is under trial for its use as combination treatment for Hepatitis D Virus.^[5]

The most common side effects included nausea, vomiting, headache, diarrhea, infection, decreased appetite and fatigue.^[3]

Lonafarnib was approved for medical use in the United States in November 2020,^[3]^[6] and in the European Union in July 2022.^[2] The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.^[7]

Medical uses

Lonafarnib is indicated to be used to reduce the risk of death due to Hutchinson-Gilford progeria syndrome and for the treatment of certain other processing-deficient progeroid laminopathies in people one year of age and older.^[3]^[4]

Ongoing studies and clinical trials have found a correlation of lonafarnib treatment with cure of hepatitis D (HDV). Up to now, the trials have proven an efficacy of lonafarnib on HDV if combined with ritonavir, as a supportive treatment for pegylated interferon alpha therapy. ^[5]

Contraindications

Lonafarnib is contraindicated for co-administration with strong or moderate CYP3A inhibitors and inducers, as well as midazolam and certain cholesterol-lowering medications.^[3]

History

Lonafarnib, a farnesyltransferase inhibitor, is an oral medication that helps prevent the buildup of defective progerin or progerin-like protein.^[3] The effectiveness of lonafarnib for the treatment of Hutchinson-Gilford progeria syndrome was demonstrated in 62 patients from two single-arm trials (Trial 1/NCT00425607 and Trial 2/NCT00916747) that were compared to matched, untreated patients from a separate natural history study.^[3]^[4] Compared to untreated patients, the lifespan of Hutchinson-Gilford progeria syndrome patients treated with lonafarnib increased by an average of three months through the first three years of treatment and by an average of 2.5 years through the maximum follow-up time of 11 years.^[3] Lonafarnib's approval for the treatment of certain processing-deficient progeroid laminopathies that are very rare took into account similarities in the underlying genetic mechanism of disease and other available data.^[3] The participants were from 34 countries around the world, including the United States.^[4]

The U.S. Food and Drug Administration (FDA) granted the application for lonafarnib priority review, orphan drug, and breakthrough therapy designations.^[3] In addition, the manufacturer received a rare pediatric disease priority review voucher.^[3] The FDA granted the approval of Zokinvy to Eiger BioPharmaceuticals, Inc.^[3]

Society and culture

Legal status

On 19 May 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization under exceptional circumstances for the medicinal product Zokinvy, intended for the treatment of patients with progeroid syndromes.^[8]^[9] The applicant for this medicinal product is EigerBio Europe Limited.^[8] It was approved for medical use in the European Union in July 2022.^[2]^[10]

Research

Lonafarnib is a farnesyltransferase inhibitor (FTI) that has been investigated in a human clinical trial as a treatment for progeria, which is an extremely rare genetic disorder in which symptoms resembling aspects of aging are manifested at a very early age.^[11]^[12]

Lonafarnib is a synthetic tricyclic halogenated carboxamide with antineoplastic properties.^[13] As such, it is used primarily for cancer treatment. For those with progeria, research has shown that the drug reduces the prevalence of stroke and transient ischemic attack, and the prevalence and frequency of headaches while taking the medication.^[14] A phase II clinical trial was completed in 2012, which showed that a cocktail of drugs that included lonafarnib and two other drugs met clinical efficacy endpoints that improved the height and diminished the rigidity of the bones of progeria patients.^{[citation needed]}

References

^ "Lonafarnib capsule". DailyMed. Archived from the original on 22 January 2021. Retrieved 17 January 2021.
^ ^a ^b ^c "Zokinvy EPAR". European Medicines Agency. 17 May 2022. Archived from the original on 2 August 2022. Retrieved 1 August 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l "FDA Approves First Treatment for Hutchinson-Gilford Progeria Syndrome and Some Progeroid Laminopathies". U.S. Food and Drug Administration (FDA) (Press release). 20 November 2020. Archived from the original on 28 November 2020. Retrieved 20 November 2020. This article incorporates text from this source, which is in the public domain.
^ ^a ^b ^c ^d "Drug Trials Snapshots: Zokinvy". U.S. Food and Drug Administration. 20 November 2020. Archived from the original on 12 December 2020. Retrieved 11 December 2020. This article incorporates text from this source, which is in the public domain.
^ ^a ^b Yurdaydin C, Keskin O, Yurdcu E, Çalişkan A, Önem S, Karakaya F, et al. (June 2022). "A phase 2 dose-finding study of lonafarnib and ritonavir with or without interferon alpha for chronic delta hepatitis". Hepatology. 75 (6): 1551–1565. doi:10.1002/hep.32259. PMID 34860418.
^ "Drug Approval Package: Zokinvy". U.S. Food and Drug Administration (FDA). 18 December 2020. Archived from the original on 22 January 2021. Retrieved 17 January 2021.
^ "New Drug Therapy Approvals 2020". U.S. Food and Drug Administration (FDA). 31 December 2020. Archived from the original on 18 January 2021. Retrieved 17 January 2021. This article incorporates text from this source, which is in the public domain.
^ ^a ^b "Zokinvy: Pending EC decision". European Medicines Agency. 19 May 2022. Archived from the original on 20 May 2022. Retrieved 20 May 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
^ "First treatment for children with Progeria or progeroid like syndromes (rare premature aging syndromes)". European Medicines Agency (EMA) (Press release). 19 May 2022. Archived from the original on 20 May 2022. Retrieved 20 May 2022.
^ "Zokinvy Product information". Union Register of medicinal products. Retrieved 3 March 2023.
^ Liu G, Marrinan CH, Taylor SA, Black S, Basso AD, Kirschmeier P, et al. (September 2007). "Enhancement of the antitumor activity of tamoxifen and anastrozole by the farnesyltransferase inhibitor lonafarnib (SCH66336)". Anti-Cancer Drugs. 18 (8): 923–31. doi:10.1097/CAD.0b013e3280c1416e. PMID 17667598. S2CID 7009843.
^ "The FTI Drug Lonafarnib" Archived 15 December 2021 at the Wayback Machine, Progeria Research Foundation. Accessed 3 October 2017.
^ "Lonafarnib". NCI Drug Dictionary. National Cancer Institute. 2 February 2011. Archived from the original on 5 November 2013. Retrieved 5 November 2013.
^ Ullrich NJ, Kieran MW, Miller DT, Gordon LB, Cho YJ, Silvera VM, et al. (July 2013). "Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment". Neurology. 81 (5): 427–30. doi:10.1212/WNL.0b013e31829d85c0. PMC 3776537. PMID 23897869.

External links

"Lonafarnib". Drug Information Portal. U.S. National Library of Medicine.
"Experimental Drug Is First To Help Kids With Premature-Aging Disease", NPR, 24 September 2012
Clinical trial number NCT00425607 for "Phase II Trial of Lonafarnib (a Farnesyltransferase Inhibitor) for Progeria" at ClinicalTrials.gov
Clinical trial number NCT00916747 for "Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria" at ClinicalTrials.gov

[Zokinvy_FDA_label-1] "Lonafarnib capsule". DailyMed. Archived from the original on 22 January 2021. Retrieved 17 January 2021.

[Zokinvy_EPAR-2] "Zokinvy EPAR". European Medicines Agency. 17 May 2022. Archived from the original on 2 August 2022. Retrieved 1 August 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[FDA_PR_20201120-3] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l "FDA Approves First Treatment for Hutchinson-Gilford Progeria Syndrome and Some Progeroid Laminopathies". U.S. Food and Drug Administration (FDA) (Press release). 20 November 2020. Archived from the original on 28 November 2020. Retrieved 20 November 2020. This article incorporates text from this source, which is in the public domain.

[FDA_snapshot-4] "Drug Trials Snapshots: Zokinvy". U.S. Food and Drug Administration. 20 November 2020. Archived from the original on 12 December 2020. Retrieved 11 December 2020. This article incorporates text from this source, which is in the public domain.

[Yurdaydin_2022-5] Yurdaydin C, Keskin O, Yurdcu E, Çalişkan A, Önem S, Karakaya F, et al. (June 2022). "A phase 2 dose-finding study of lonafarnib and ritonavir with or without interferon alpha for chronic delta hepatitis". Hepatology. 75 (6): 1551–1565. doi:10.1002/hep.32259. PMID 34860418.

[6] "Drug Approval Package: Zokinvy". U.S. Food and Drug Administration (FDA). 18 December 2020. Archived from the original on 22 January 2021. Retrieved 17 January 2021.

[7] "New Drug Therapy Approvals 2020". U.S. Food and Drug Administration (FDA). 31 December 2020. Archived from the original on 18 January 2021. Retrieved 17 January 2021. This article incorporates text from this source, which is in the public domain.

[Zokinvy:_Pending_EC_decision-8] "Zokinvy: Pending EC decision". European Medicines Agency. 19 May 2022. Archived from the original on 20 May 2022. Retrieved 20 May 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[9] "First treatment for children with Progeria or progeroid like syndromes (rare premature aging syndromes)". European Medicines Agency (EMA) (Press release). 19 May 2022. Archived from the original on 20 May 2022. Retrieved 20 May 2022.

[10] "Zokinvy Product information". Union Register of medicinal products. Retrieved 3 March 2023.

[pmid17667598-11] Liu G, Marrinan CH, Taylor SA, Black S, Basso AD, Kirschmeier P, et al. (September 2007). "Enhancement of the antitumor activity of tamoxifen and anastrozole by the farnesyltransferase inhibitor lonafarnib (SCH66336)". Anti-Cancer Drugs. 18 (8): 923–31. doi:10.1097/CAD.0b013e3280c1416e. PMID 17667598. S2CID 7009843.

[12] "The FTI Drug Lonafarnib" Archived 15 December 2021 at the Wayback Machine, Progeria Research Foundation. Accessed 3 October 2017.

[13] "Lonafarnib". NCI Drug Dictionary. National Cancer Institute. 2 February 2011. Archived from the original on 5 November 2013. Retrieved 5 November 2013.

[14] Ullrich NJ, Kieran MW, Miller DT, Gordon LB, Cho YJ, Silvera VM, et al. (July 2013). "Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment". Neurology. 81 (5): 427–30. doi:10.1212/WNL.0b013e31829d85c0. PMC 3776537. PMID 23897869.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

PROFILPELAJAR.COM

Lonafarnib

Medical uses

Contraindications

History

Society and culture

Legal status

Research

References

External links

Read other articles:

Tai Chi Master (film)

9M337 Sosna-R

羅生門 (電影)

Organisasi Kerja Sama Islam

Serie A 1957-1958

Mahkamah Kasasi (Prancis)

Osaka

Elías Aguilar

Bibliography of Australian history

末沙布

俄亥俄州

乌克兰总理

Indiana

Mercury (element)

Juan Ponce de León

Palestinian wine

ريح

TVP Info

1950 Maltese general election

Carmine Rojas