Frank was director of the Laura Spelman Rockefeller Memorial from 1923 to 1929. He directed the child-development program in the Rockefeller Foundation from 1929 to 1933 and became part of its General Education Board in 1933. From 1936 to 1942 he was vice-president of the Josiah Macy Foundation, Frank was among the attendees of the first Macy meeting in 1942 with other scientists such as the anthropologists Gregory Bateson and Margaret Mead, the neurophysiologist Warren McCulloch, the physician and physiologist Arturo Rosenblueth and the psychoanalyst Lawrence Kubie. From 1945 to 1950 he was director of the Caroline Zachry Institute of Human Development.[5]
Beside his administrative career he was visiting professor and lecturer at several institutions, member of many learned societies and organizations, and wrote a series of books of educational and social matters. He received the Lasker Award in mental health in 1947, the Parents' magazine award for an outstanding book in 1950.[3] In some of these writings, Frank suggested that the American focus on individualism should be re-balanced in favor of more group responsibility.[6]
His papers are held at the National Library of Medicine in Bethesda, Maryland.[7]